Drug tolerability: how much ambiguity can be tolerated? A systematic review of the assessment of tolerability in clinical studies

2021 ◽  
Author(s):  
Vid Stanulović ◽  
Marina Hodolic ◽  
Dimos D. Mitsikostas ◽  
Dimitrios Papadopoulos
Keyword(s):  
Systematic Review ◽  
Clinical Studies ◽  
Drug Tolerability

scholarly journals Interferon therapy in patients with SARS, MERS, and COVID-19: A systematic review and meta-analysis of clinical studies

2021 ◽  
pp. 174248
Author(s):  
Kiarash Saleki ◽  
Shakila Yaribash ◽  
Mohammad Banazadeh ◽  
Ehsan Hajihosseinlou ◽  
Mahdi Gouravani ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Studies ◽  
Interferon Therapy ◽  
Meta Analysis

scholarly journals Resistance to ceftazidime/avibactam in infections and colonizations by KPC-producing Enterobacterales: a systematic review of observational clinical studies

2021 ◽  
Author(s):  
Stefano Di Bella ◽  
Daniele Roberto Giacobbe ◽  
Alberto Enrico Maraolo ◽  
Valentina Viaggi ◽  
Roberto Luzzati ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Studies

scholarly journals Inhibition of Androgen Signalling Improves the Outcomes of Therapies for Bladder Cancer: Results from a Systematic Review of Preclinical and Clinical Evidence and Meta-Analysis of Clinical Studies

Diagnostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 351
Author(s):  
Massimiliano Creta ◽  
Giuseppe Celentano ◽  
Luigi Napolitano ◽  
Roberto La Rocca ◽  
Marco Capece ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bladder Cancer ◽  
Relative Risk ◽  
Clinical Studies ◽  
Clinical Evidence ◽  
Meta Analysis ◽  
Bladder Tumour ◽  
Signalling Pathways ◽  
Reductase Inhibitors ◽  
The Impact

Bladder cancer (BCa) is an endocrine-related tumour and the activation of androgen signalling pathways may promote bladder tumorigenesis. We summarized the available preclinical and clinical evidence on the implications of the manipulation of androgen signalling pathways on the outcomes of BCa therapies. A systematic review was performed in December 2020. We included papers that met the following criteria: original preclinical and clinical research; evaluating the impact of androgen signalling modulation on the outcomes of BCa therapies. Six preclinical and eight clinical studies were identified. The preclinical evidence demonstrates that the modulation of androgen receptor-related pathways has the potential to interfere with the activity of the Bacillus Calmette Guerin, doxorubicin, cisplatin, gemcitabine, and radiotherapy. The relative risk of BCa recurrence after transurethral resection of the bladder tumour (TURBT) is significantly lower in patients undergoing therapy with 5 alpha reductase inhibitors (5-ARIs) or androgen deprivation therapy (ADT) (Relative risk: 0.50, 95% CI: 0.30–0.82; p = 0.006). Subgroup analysis in patients receiving 5-ARIs revealed a relative risk of BCa recurrence of 0.46 (95% CI: 0.22–0.95; p = 0.040). A significant negative association between the ratio of T1 BCa patients in treated/control groups and the relative risk of BCa recurrence was observed. Therapy with 5-ARIs may represent a potential strategy aimed at reducing BCa recurrence rate, mainly in patients with low stage disease. Further studies are needed to confirm these preliminary data.

Vancomycin-resistant enterococci in Iran: A systematic review and meta-analysis of non-clinical studies

Gene Reports ◽  
2021 ◽  
pp. 101265
Author(s):  
Fereshteh Hasanpour ◽  
Zohreh Neyestani ◽  
Mohsen Arzanlou ◽  
Eslam Moradi-Asl ◽  
Amirhossein Sahebkar ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Studies ◽  
Meta Analysis ◽  
Vancomycin Resistant Enterococci ◽  
Vancomycin Resistant

Prenatal alcohol consumption and placental outcomes: A systematic review and meta-analysis of clinical studies

2021 ◽  
Author(s):  
Sarah E. Steane ◽  
Sophia L. Young ◽  
Vicki L. Clifton ◽  
Linda A. Gallo ◽  
Lisa K. Akison ◽  
...  
Keyword(s):  
Systematic Review ◽  
Alcohol Consumption ◽  
Clinical Studies ◽  
Meta Analysis ◽  
Prenatal Alcohol
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