scholarly journals Tacrolimus dose, blood concentrations and acute nephrotoxicity, but not CYP3A5/ABCB1 genetics, are associated with allograft tacrolimus concentrations in renal transplant recipients

2021 ◽  
Author(s):  
Benedetta C. Sallustio ◽  
Benjamin D. Noll ◽  
Rong Hu ◽  
Daniel T. Barratt ◽  
Jonathan Tuke ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Blood Concentrations ◽  
Tacrolimus Dose

Tacrolimus Dose in Black Renal Transplant Recipients

2007 ◽  
Vol 83 (7) ◽  
pp. 997-999 ◽  
Author(s):  
Nidyanandh Vadivel ◽  
Ashwani Garg ◽  
David W. Holt ◽  
Rene W. S. Chang ◽  
Iain A. M. MacPhee
Keyword(s):  
Renal Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Tacrolimus Dose

Using genetic and clinical factors to predict tacrolimus dose in renal transplant recipients

2010 ◽  
Vol 11 (10) ◽  
pp. 1389-1402 ◽  
Author(s):  
Ping Wang ◽  
Yong Mao ◽  
Juan Razo ◽  
Xiaobo Zhou ◽  
Stephen TC Wong ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Clinical Factors ◽  
Tacrolimus Dose

Low Tacrolimus Dose Requirements in Renal Transplant Recipients in the Omani Population: Implications for Pharmacogenetics?

2005 ◽  
Vol 37 (7) ◽  
pp. 2911-2912 ◽  
Author(s):  
N. Mohsin ◽  
A. Pakkyara ◽  
M. Budruddin ◽  
F. Obaid ◽  
A. Kumar ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Tacrolimus Dose

scholarly journals Tacrolimus dose requirement in renal transplant recipients is significantly higher when used in combination with corticosteroids

2003 ◽  
Vol 56 (3) ◽  
pp. 327-330 ◽  
Author(s):  
Dennis A. Hesselink ◽  
Hien Ngyuen ◽  
Marike Wabbijn ◽  
Peter J. H. Smak Gregoor ◽  
Ewout W. Steyerberg ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Dose Requirement ◽  
Tacrolimus Dose

scholarly journals MO920TRANSITION FROM GENERIC TO BRAND TACROLIMUS IN TUNISIAN RENAL TRANSPLANT RECIPIENTS

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Dorra Amor ◽  
Sahtout Wissal ◽  
A Ellouz ◽  
Ameni Abderrahman ◽  
Awatef Azzabi ◽  
...  
Keyword(s):  
Renal Transplant ◽  
University Hospital ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Post Transplantation ◽  
Blood Concentrations ◽  
Transplant Patients ◽  
Trough Blood ◽  
Bioequivalence Testing ◽  
Adult Volunteers

Abstract Background and Aims Due to unavailability of the generic tacrolimus, commonly used in renal transplant patients in Tunisia, all renal transplant switched to the Brand. No previous studies have assessed the pharmacokinetic differences of this generic tacrolimus compared to the brand. The aim of the present study was to evaluate the effect of this switch on the tacrolimus dose (D) and on the dose-adjusted tacrolimus trough blood concentrations (C0/D) in Tunisian renal transplant recipients. Method For the 255 renal transplant monitored in biochemestry department of Sahloul University hospital, 808tacrolimus trough concentration (C0) were collected from october 2018 to February 2020 and were divided to 406 C0 determination before switch and 402 after switch. The dose and the post-transplantation period was recorded for each C0. Results The generic tacrolimus doses used were significantly higher compared to the brand: 0,12 mg/kg [0,02-0,6] vs 0,11 mg/kg [0,02-0,22] p<0,001 and this was reported in different post graft periods: 0,17 [0,03-0,22] vs 0,13 [0,06-0,22] p<0,001in the 3 first months after the transplantation and 0,11 [0,02-0,48] vs 0,08 [0,02-0,22] p<0,001 above.The C0/D were significantly lowe runder the the generic tacrolimus compared to the brand 48,34ng/ml per mg/kg/day [11,58-210,00] vs77,35ng/ml per mg/kg/day[19,38-221,67]; p<0,001 and this was reported in different post graft periods: 71,12ng/ml per mg/kg/day [6,80, 451,56] vs80,9750ng/ml per mg/kg/day [17,33-458,80] p=0,017 in the 3 first months after the transplantation and 71,12ng/ml per mg/kg/day [6,80, 451,56] vs80,9750ng/ml per mg/kg/day [17,33-458,80] p=0,017 above. Dose needed to reach target tacrolimus C0 seems to be higher with the generic tacrolimus compared to the brand. Conclusion Approval of a generic is dependent on bioequivalence testing in healthy adult volunteers after a single dose, however studies on renal graft recipient populations after chronic use are needed to assed bioequivalence in this special population.

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