Impact of Cytochrome P450 3A and ATP-Binding Cassette Subfamily B Member 1 Polymorphisms on Tacrolimus Dose-Adjusted Trough Concentrations Among Korean Renal Transplant Recipients

2012 ◽  
Vol 44 (1) ◽  
pp. 109-114 ◽  
Author(s):  
J.-H. Cho ◽  
Y.-D. Yoon ◽  
J.-Y. Park ◽  
E.-J. Song ◽  
J.-Y. Choi ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Renal Transplant ◽  
Atp Binding ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Cytochrome P450 3A ◽  
Trough Concentrations ◽  
Tacrolimus Dose ◽  
Atp Binding Cassette

Steady-state concentration of cyclosporin G (OG37-325) and its metabolites in renal transplant recipients

1994 ◽  
Vol 40 (4) ◽  
pp. 613-616 ◽  
Author(s):  
L J Langman ◽  
A B Leichtman ◽  
W F Weitzel ◽  
R W Yatscoff
Keyword(s):  
Steady State ◽  
Renal Transplant ◽  
Secondary Metabolites ◽  
Whole Blood ◽  
Relative Concentration ◽  
Cross Reactivity ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Dosing Interval ◽  
Trough Concentrations

Abstract The steady-state concentrations of cyclosporin G (OG37-325) (CsG) and six of its metabolites (GM1, GM9, GM4N, GM1c, GM1c9, GM19) were measured throughout the 12-h dosing interval in six renal transplant recipients receiving CsG as prophylaxis against acute cellular rejection. The mean 12-h whole-blood trough concentrations (micrograms/L) were CsG, 131 +/- 26; GM1, 79 +/- 55; GM9, 110 +/- 114; GM4N, 28 +/- 18; GM1c, 31 +/- 18; GM1c9, 216 +/- 145; and GM19, 303 +/- 217. The relative concentration of the primary metabolites (GM1, GM9, GM4N) remained stable with respect to CsG throughout the dosing interval, whereas that of the secondary metabolites increased. The secondary metabolites GM19 and GM1c9 exhibited extensive between-patient variation. We investigated the effect of these metabolites on commercially available monoclonal antibody-based fluorescence polarization immunoassays (FPIA) and RIAs adapted for measurement of CsG. The 12-h whole-blood trough concentrations measured by FPIA and RIA exceed those measured by HPLC by 19% and 36%, respectively. These measured biases corresponded closely with the calculated biases (FPIA 19%, RIA 28%) based on the known cross-reactivities of CsG metabolites and their concentrations. These results suggest that cross-reactivity with metabolites account for a large part of the bias observed in immunoassays of CsG.

Tacrolimus Dose in Black Renal Transplant Recipients

2007 ◽  
Vol 83 (7) ◽  
pp. 997-999 ◽  
Author(s):  
Nidyanandh Vadivel ◽  
Ashwani Garg ◽  
David W. Holt ◽  
Rene W. S. Chang ◽  
Iain A. M. MacPhee
Keyword(s):  
Renal Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Tacrolimus Dose

Using genetic and clinical factors to predict tacrolimus dose in renal transplant recipients

2010 ◽  
Vol 11 (10) ◽  
pp. 1389-1402 ◽  
Author(s):  
Ping Wang ◽  
Yong Mao ◽  
Juan Razo ◽  
Xiaobo Zhou ◽  
Stephen TC Wong ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Clinical Factors ◽  
Tacrolimus Dose
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