Domperidone and the Risks of Sudden Cardiac Death and Ventricular Arrhythmia: A Systematic Review and Meta‐Analysis of Observational Studies

2021 ◽  
Author(s):  
Linda B. Ou ◽  
Carolina Moriello ◽  
Antonios Douros ◽  
Kristian B. Filion
Keyword(s):  
Systematic Review ◽  
Sudden Cardiac Death ◽  
Ventricular Arrhythmia ◽  
Cardiac Death ◽  
Observational Studies ◽  
Meta Analysis

Sa1706 A Meta-Analysis and Systematic Review of Serious Ventricular Arrhythmia and Sudden Cardiac Death With Domperidone Use

2016 ◽  
Vol 150 (4) ◽  
pp. S352
Author(s):  
Mohammad Bashashati ◽  
Irene Sarosiek ◽  
Sharareh Moraveji ◽  
Alok Dwivedi ◽  
Tariq Siddiqui ◽  
...  
Keyword(s):  
Systematic Review ◽  
Sudden Cardiac Death ◽  
Ventricular Arrhythmia ◽  
Cardiac Death ◽  
Meta Analysis

scholarly journals Antidepressants and Risk of Sudden Cardiac Death: A Network Meta-Analysis and Systematic Review

2021 ◽  
Vol 9 (2) ◽  
pp. 26
Author(s):  
Narut Prasitlumkum ◽  
Wisit Cheungpasitporn ◽  
Nithi Tokavanich ◽  
Kimberly R. Ding ◽  
Jakrin Kewcharoen ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Mental Disorders ◽  
Ventricular Arrhythmia ◽  
Cardiac Death ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Meta Analysis ◽  
Tricyclic Antidepressant ◽  
Systemic Review ◽  
Analysis Model ◽  
Antidepressant Use

Background: Antidepressants are one of the most prescribed medications, particularly for patients with mental disorders. Nevertheless, there are still limited data regarding the risk of ventricular arrhythmia (VA) and sudden cardiac death (SCD) associated with these medications. Thus, we performed systemic review and meta-analysis to characterize the risks of VA and SCD among patients who used common antidepressants. Methods: A literature search for studies that reported risk of ventricular arrhythmias and sudden cardiac death in antidepressant use from MEDLINE, EMBASE, and Cochrane Database from inception through September 2020. A random-effects model network meta-analysis model was used to analyze the relation between antidepressants and VA/SCD. Surface Under Cumulative Ranking Curve (SUCRA) was used to rank the treatment for each outcome. Results: The mean study sample size was 355,158 subjects. Tricyclic antidepressant (TCA) patients were the least likely to develop ventricular arrhythmia events/sudden cardiac deaths at OR 0.24, 0.028–1.2, OR 0.32 (95% CI 0.038–1.6) for serotonin and norepinephrine reuptake inhibitors (SNRI), and OR 0.36 (95% CI 0.043, 1.8) for selective serotonin reuptake inhibitors (SSRI), respectively. According to SUCRA analysis, TCA was on a higher rank compared to SNRI and SSRI considering the risk of VA/SCD. Conclusion: Our network meta-analysis demonstrated the low risk of VA/SCD among patients using antidepressants for SNRI, SSRI and especially, TCA. Despite the relatively lowest VA/SCD in TCA, drug efficacy and other adverse effects should be taken into account in patients with mental disorders.

scholarly journals Obesity Associates with Increased Risk of Sudden Cardiac Death: A Systematic Review and Meta-Analysis

2017 ◽  
Vol 26 ◽  
pp. S186 ◽  
Author(s):  
T. Agbaedeng ◽  
R. Mahajan ◽  
D. Munawar ◽  
A. Elliott ◽  
D. Twomey ◽  
...  
Keyword(s):  
Systematic Review ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Meta Analysis ◽  
Increased Risk

scholarly journals Incidence of sudden cardiac death in the young: a systematic review

BMJ Open ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. e040815
Author(s):  
Keith Couper ◽  
Oliver Putt ◽  
Richard Field ◽  
Kurtis Poole ◽  
William Bradlow ◽  
...  
Keyword(s):  
Systematic Review ◽  
Sudden Cardiac Death ◽  
General Population ◽  
Cardiac Death ◽  
Data Extraction ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Older Individuals ◽  
Eligibility Criteria ◽  
Prevalence Studies

ObjectiveTo summarise studies describing incidence of sudden cardiac death in a general population of young individuals to inform screening policy.DesignSystematic review.Data sourcesDatabase searches of MEDLINE, EMBASE and the Cochrane library (all inception to current) on 29 April 2019 (updated 16 November 2019), and forward/backward citation tracking of eligible studies.Study eligibility criteriaAll studies that reported incidence of sudden cardiac death in young individuals (12–39 years) in a general population, with no restriction on language or date. Planned subgroups were incidence by age, sex, race and athletic status (including military personnel).Data extractionTwo reviewers independently assessed study eligibility, extracted study data and assessed risk of bias using the Joanna Briggs Institute critical appraisal checklist for prevalence studies.AnalysisReported incidence of sudden cardiac death in the young per 100 000 person-years.Results38 studies that reported incidence across five continents. We identified substantial heterogeneity in population, sudden cardiac death definition, and case ascertainment methods, precluding meta-analysis. Median reported follow-up years was 6.97 million (IQR 2.34 million–23.70 million) and number of sudden cardiac death cases was 64 (IQR 40–251). In the general population, the median of reported incidence was 1.7 sudden cardiac death per 100 000 person-years (IQR 1.3–2.6, range 0.75–11.9). Most studies (n=14, 54%) reported an incidence between one and two cases per 100 000 person-years. Incidence was higher in males and older individuals.ConclusionsThis systematic review identified variability in the reported incidence of sudden cardiac death in the young across studies. Most studies reported an incidence between one and two cases per 100 000 person-years.PROSPERO registration numberCRD42019120563.

Mitral valve prolapse and sudden cardiac death: a systematic review and meta-analysis

Heart ◽  
2018 ◽  
Vol 105 (2) ◽  
pp. 144-151 ◽  
Author(s):  
Chrishan J Nalliah ◽  
Rajiv Mahajan ◽  
Adrian D Elliott ◽  
Haris Haqqani ◽  
Dennis H Lau ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Sudden Cardiac Death ◽  
Mitral Valve ◽  
Mitral Valve Prolapse ◽  
Cardiac Death ◽  
Meta Analysis ◽  
Ventricular Ectopy ◽  
T Wave ◽  
Ventricular Fibrosis

ObjectivesMitral valve prolapse (MVP) is commonly observed as a benign finding. However, the literature suggests that it may be associated with sudden cardiac death (SCD). We performed a meta-analysis and systematic review to determine the: (1) prevalence of MVP in the general population; (2) prevalence of MVP in all SCD and unexplained SCD; (3) incidence of SCD in MVP and (4) risk factors for SCD.MethodsThe English medical literature was searched for: (1) MVP community prevalence; (2) MVP prevalence in SCD cohorts; (3) incidence SCD in MVP and (4) SCD risk factors in MVP. Thirty-four studies were identified for inclusion. This study was registered with PROSPERO (CRD42018089502).ResultsThe prevalence of MVP was 1.2% (95% CI 0.5 to 2.0) in community populations. Among SCD victims, the cause of death remained undetermined in 22.1% (95% CI 13.4 to 30.7); of these, MVP was observed in 11.7% (95% CI 5.8 to 19.1). The incidence of SCD in the MVP population was 0.14% (95% CI 0.1 to 0.3) per year. Potential risk factors for SCD include bileaflet prolapse, ventricular fibrosis complex ventricular ectopy and ST-T wave abnormalities.ConclusionThe high prevalence of MVP in cohorts of unexplained SCD despite low population prevalence provides indirect evidence of an association of MVP with SCD. The absolute number of people exposed to the risk of SCD is significant, although the incidence of life-threatening arrhythmic events in the general MVP population remains low. High-risk features include bileaflet prolapse, ventricular fibrosis, ST-T wave abnormalities and frequent complex ventricular ectopy.Trial registrationPROSPERO (CRD42018089502).

Causes of Sudden Cardiac Death in Young Athletes and Non-athletes: Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Flavio D'Ascenzi ◽  
Francesca Valentini ◽  
Simone Pistoresi ◽  
Federica Frascaro ◽  
Pietro Piu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Meta Analysis ◽  
Young Athletes
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