Mining scientific advice reports on cell‐based products: Insight into the nonclinical development program

2020 ◽  
Author(s):  
Tineke Hoorn ◽  
Tahira Nakchedi ◽  
A. Charlotte M.T. Wolf ◽  
Anna M.G. Pasmooij ◽  
Jan Willem Laan ◽  
...  
Keyword(s):  
Development Program ◽  
Scientific Advice ◽  
Insight Into

scholarly journals Twenty first century development in the Hungarian Defence Forces : The KC-390 tactical military transport aircraft

Haditechnika ◽  
2021 ◽  
Vol 55 (4) ◽  
pp. 20-26
Author(s):  
András Füleky
Keyword(s):  
Development Program ◽  
First Century ◽  
Historical Overview ◽  
Transport Aircraft ◽  
Twenty First Century ◽  
Military Development ◽  
The Military ◽  
Century Development ◽  
Insight Into

The paper gives a short historical overview of the types of aircraft representing airlift capabilities in certain periods of the life of the Hungarian Defence Forces and pays tribute to air and ground operations personnel. Describing the military transport aircraft capabilities to be developed within the framework of the Zrínyi Defence and Military Development Program, the reader will gain insight into the ever evolving he reader will gain insight into the ever evolving nature of complex airlift capabilities and the tasks resulting from participation in Alliance, international and domestic missions. The article provides a detailed description of the new, soon to be acquired military transport aircraft Embraer KC-390 Millennium.

scholarly journals Mining scientific advice reports on cell-based products; insight in the non-clinical development program.

2020 ◽  
Author(s):  
Tineke van den Hoorn ◽  
Tahira Nakchedi ◽  
Charlotte de Wolf ◽  
Marjon Pasmooij ◽  
Jan Willem van der Laan ◽  
...  
Keyword(s):  
Development Program ◽  
Clinical Development ◽  
Scientific Advice ◽  
Clinical Development Program

Patterns of Practice and Teacher Identity

2017 ◽  
pp. 527-537
Author(s):  
Nicholas E. Husbye ◽  
Yolanda Alovar ◽  
King Song
Keyword(s):  
Professional Development ◽  
Teacher Identity ◽  
English Learners ◽  
Development Program ◽  
Professional Development Program ◽  
School Students ◽  
Public School Students ◽  
Effective Learning ◽  
Patterns Of Practice ◽  
Insight Into

The increasing diversity of public school students presents challenges both to institutions of teacher education as well as professional development providers as mainstream educators must now be versed in skills and techniques that result in rigorous and effective learning for English learners (ELs). This chapter presents insights from a university-run professional development program for pre- and in-service teachers closely examining the ways one participant engaged in a variety of practice-based identities within her classroom as a result of her participation in the professional development program. These practice-based identities include the tool collector, content monomath, and polymath, with each bring particular strengths to the classroom for ELs. This work suggests a need to consider the ways in which professional development participants conceptualize themselves as they make sense of their own educational experience as well as to provide insight into the most meaningful elements of such an experience.

scholarly journals Optimizing the Outcome of Anti-Myeloma Treatment with Daratumumab

2021 ◽  
Vol 10 (5) ◽  
pp. 1002
Author(s):  
Torben Plesner
Keyword(s):  
Multiple Myeloma ◽  
Scientific Literature ◽  
Development Program ◽  
Clinical Development ◽  
High Expectations ◽  
Clinical Development Program ◽  
Duration Of Therapy ◽  
Immune Mediated ◽  
Insight Into ◽  
Breakthrough Designation

A search of the scientific literature for Daratumumab and myeloma gives more than 600 results (January 2021), which reflects the interest and activity around this antibody, an interest that was also reflected by the assignment of breakthrough designation for Daratumumab as a treatment for multiple myeloma by FDA in 2013. The high expectations have been supported and met due to a very active clinical development program, and our insight into Daratumumab’s modes of action have been expanded by a concomitant, systematic activity of translational research. The scope of this article is to point to some areas where the outcome of treatment with Daratumumab for multiple myeloma may be improved with a focus on areas such as when to initiate treatment with Daratumumab, the use of supportive treatment, duration of therapy and some general thoughts about anti-myeloma treatment as a two-step process involving initial de-bulking followed by reprogramming of the host’s immune system and immune-mediated control of myeloma.

DESIGNING THE DEVELOPMENT PROGRAM OF AN EDUCATIONAL ORGANIZATION AS AN ANTI-CRISIS STRATEGY

2020 ◽  
pp. 39-44
Author(s):  
R.M. Gaynutdinov ◽  
Keyword(s):  
Educational System ◽  
Task Force ◽  
Development Program ◽  
Modern World ◽  
Educational Organization ◽  
Future Directions ◽  
Long Run ◽  
The Right ◽  
Insight Into

Despite the overall instability and unpredictability of the modern world and to be precise Russian educational system, the importance of having an insight into the perspectives and future directions of a particular educational organization cannot be doubted. That is why it is vital to explore the topic of choosing the right organizational priorities in short and long run and instruments to incorporate them into the task force.

Calibration problems in hydrogen luminosities

1966 ◽  
Vol 24 ◽  
pp. 322-330
Author(s):  
A. Beer
Keyword(s):  
Galactic Structure ◽  
B Stars ◽  
Insight Into

The investigations which I should like to summarize in this paper concern recent photo-electric luminosity determinations of O and B stars. Their final aim has been the derivation of new stellar distances, and some insight into certain patterns of galactic structure.

Stochasting modeling of planetary ring systems

1984 ◽  
Vol 75 ◽  
pp. 461-469 ◽  
Author(s):  
Robert W. Hart
Keyword(s):  
Maximum Entropy ◽  
Ring System ◽  
The Sun ◽  
Ultimate State ◽  
Interparticle Interactions ◽  
Ring Systems ◽  
First Order ◽  
Planetary Ring ◽  
Insight Into

ABSTRACTThis paper models maximum entropy configurations of idealized gravitational ring systems. Such configurations are of interest because systems generally evolve toward an ultimate state of maximum randomness. For simplicity, attention is confined to ultimate states for which interparticle interactions are no longer of first order importance. The planets, in their orbits about the sun, are one example of such a ring system. The extent to which the present approximation yields insight into ring systems such as Saturn's is explored briefly.

Skeletal elements of crinoid echinoderms: High-resolution structural and microanalytical results

1983 ◽  
Vol 41 ◽  
pp. 194-195
Author(s):  
D. F. Blake ◽  
L. F. Allard ◽  
D. R. Peacor
Keyword(s):  
High Resolution ◽  
Marine Invertebrates ◽  
Sea Urchins ◽  
Structural Features ◽  
Sea Stars ◽  
High Resolution Tem ◽  
Relationship Of ◽  
The Relationship ◽  
Insight Into

Echinodermata is a phylum of marine invertebrates which has been extant since Cambrian time (c.a. 500 m.y. before the present). Modern examples of echinoderms include sea urchins, sea stars, and sea lilies (crinoids). The endoskeletons of echinoderms are composed of plates or ossicles (Fig. 1) which are with few exceptions, porous, single crystals of high-magnesian calcite. Despite their single crystal nature, fracture surfaces do not exhibit the near-perfect {10.4} cleavage characteristic of inorganic calcite. This paradoxical mix of biogenic and inorganic features has prompted much recent work on echinoderm skeletal crystallography. Furthermore, fossil echinoderm hard parts comprise a volumetrically significant portion of some marine limestones sequences. The ultrastructural and microchemical characterization of modern skeletal material should lend insight into: 1). The nature of the biogenic processes involved, for example, the relationship of Mg heterogeneity to morphological and structural features in modern echinoderm material, and 2). The nature of the diagenetic changes undergone by their ancient, fossilized counterparts. In this study, high resolution TEM (HRTEM), high voltage TEM (HVTEM), and STEM microanalysis are used to characterize tha ultrastructural and microchemical composition of skeletal elements of the modern crinoid Neocrinus blakei.

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