scholarly journals Impact of EU regulatory label changes for diclofenac in people with cardiovascular disease in four countries: Interrupted time series regression analysis

Author(s):  
Daniel R. Morales ◽  
Steven V. Morant ◽  
Thomas M. MacDonald ◽  
Jesper Hallas ◽  
Martin Thomsen Ernst ◽  
...  
2015 ◽  
Vol 15 (2) ◽  
pp. 27-36
Author(s):  
Robert Landry ◽  
S. Lowe ◽  
Benjamin Boozer ◽  
John Sneed ◽  
Cynthia Sneed

Author(s):  
T. Giannouchos ◽  
A. Giannouchos ◽  
I. Christodoulou ◽  
E. Steletou ◽  
K. Souliotis

AbstractBackgroundThe Greek authorities implemented the strong social distancing measures within the first few weeks after the first confirmed case of the virus to curtail the COVID-19 growth rate.ObjectivesTo estimate the effect of the two-stage strong social distancing measures, the closure of all non-essential shopping centers and businesses on March 16 and the shelter in place orders (SIPOs) on March 23 on the COVID-19 growth rate in GreeceMethodsWe obtained data on COVID-19 cases in Greece from February 26th through May 4th from publicly available sources. An interrupted time-series regression analysis was used to estimate the effect of the measures on the exponential growth of confirmed COVID-19 cases, controlling for the number of daily testing, and weekly fixed-effects.ResultsThe growth rate of the COVID-19 cases in the pre-policies implementation period was positive as expected (p=0.003). Based on the estimates of the interrupted time-series, our results indicate that the SIPO on March 23 significantly slowed the growth rate of COVID-19 in Greece (p=0.04). However, we did not find evidence on the effectiveness of standalone and partial measures such as the non-essential business closures implemented on March 16 on the COVID-19 spread reduction.DiscussionThe combined social distancing measures implemented by the Greek authorities within the first few weeks after the first confirmed case of the virus reduced the COVID-19 growth rate. These findings provide evidence and highlight the effectiveness of these measures to flatten the curve and to slow the spread of the virus.


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