scholarly journals Impact of EMA regulatory label changes on hydroxyzine initiation, discontinuation and switching to other medicines in Denmark, Scotland, England and the Netherlands: an interrupted time series regression analysis

Author(s):  
Daniel R. Morales ◽  
Tatiana Macfarlane ◽  
Thomas M. MacDonald ◽  
Jesper Hallas ◽  
Martin Thomsen Ernst ◽  
...  
2015 ◽  
Vol 15 (2) ◽  
pp. 27-36
Author(s):  
Robert Landry ◽  
S. Lowe ◽  
Benjamin Boozer ◽  
John Sneed ◽  
Cynthia Sneed

Author(s):  
T. Giannouchos ◽  
A. Giannouchos ◽  
I. Christodoulou ◽  
E. Steletou ◽  
K. Souliotis

AbstractBackgroundThe Greek authorities implemented the strong social distancing measures within the first few weeks after the first confirmed case of the virus to curtail the COVID-19 growth rate.ObjectivesTo estimate the effect of the two-stage strong social distancing measures, the closure of all non-essential shopping centers and businesses on March 16 and the shelter in place orders (SIPOs) on March 23 on the COVID-19 growth rate in GreeceMethodsWe obtained data on COVID-19 cases in Greece from February 26th through May 4th from publicly available sources. An interrupted time-series regression analysis was used to estimate the effect of the measures on the exponential growth of confirmed COVID-19 cases, controlling for the number of daily testing, and weekly fixed-effects.ResultsThe growth rate of the COVID-19 cases in the pre-policies implementation period was positive as expected (p=0.003). Based on the estimates of the interrupted time-series, our results indicate that the SIPO on March 23 significantly slowed the growth rate of COVID-19 in Greece (p=0.04). However, we did not find evidence on the effectiveness of standalone and partial measures such as the non-essential business closures implemented on March 16 on the COVID-19 spread reduction.DiscussionThe combined social distancing measures implemented by the Greek authorities within the first few weeks after the first confirmed case of the virus reduced the COVID-19 growth rate. These findings provide evidence and highlight the effectiveness of these measures to flatten the curve and to slow the spread of the virus.


2020 ◽  
Vol 100 (4) ◽  
pp. 510-530
Author(s):  
Duane Stanton ◽  
Xiaohan Mei ◽  
Sohee Kim ◽  
Dale Willits ◽  
Mary Stohr ◽  
...  

In 2012, Washington State legalized the production, sale, and possession of marijuana through Initiative 502. Advocates of legalization argued that it would decrease the jail population and reduce the disproportionate incarceration of minorities, reasoning that the police would refocus their resources on other matters. In order to evaluate this assumption, we examined jail booking data using a set of interrupted time-series regression models. Our findings indicate that jail population trends differ among counties across time and with respect to impacts on minorities and women. With regard to ethnic and racial disproportionate impact, there appears to be little positive change.


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