scholarly journals Acute liver injury following turmeric use in Tuscany: An analysis of the Italian Phytovigilance database and systematic review of case reports

2020 ◽  
Author(s):  
Niccolò Lombardi ◽  
Giada Crescioli ◽  
Valentina Maggini ◽  
Ilaria Ippoliti ◽  
Francesca Menniti‐Ippolito ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Injury ◽  
Acute Liver Injury ◽  
Case Reports

Systematic review of severe acute liver injury caused by terbinafine

2014 ◽  
Vol 36 (4) ◽  
pp. 679-683 ◽  
Author(s):  
Jun Yan ◽  
Xiaolin Wang ◽  
Shengli Chen
Keyword(s):  
Systematic Review ◽  
Liver Injury ◽  
Acute Liver Injury

scholarly journals Clozapine-induced liver injury and pleural effusion

2014 ◽  
Vol 6 (2) ◽  
pp. 36-37
Author(s):  
Joseph P.M. Kane ◽  
Francis A. O'Neill
Keyword(s):  
Pleural Effusion ◽  
Liver Injury ◽  
Liver Enzymes ◽  
Clinical Symptoms ◽  
Acute Liver Injury ◽  
Case Reports ◽  
High Index ◽  
Documented Case ◽  
High Index Of Suspicion ◽  
Symptoms And Signs

Clozapine, whilst associated commonly with a transient and benign increase in liver enzymes, has also been associated with varying presentations of hepatitis in existing case reports. This report describes what we believe to be the first documented case of acute liver injury and pleural effusion associated with clozapine, resolving after cessation of the agent. The case supports existing literature in advocating a high index of suspicion, particularly in the 4-5 weeks following clozapine initiation, when considering nonspecific clinical symptoms and signs.

scholarly journals Prevalence of acute liver injury and hypertransaminemia in patients with COVID-19: a protocol for a systematic review

BMJ Open ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. e040517
Author(s):  
Gang Li ◽  
Yongxing Xu ◽  
Yi Tian Yang ◽  
Peng Fei Liu
Keyword(s):  
Systematic Review ◽  
Liver Injury ◽  
Acute Liver Injury ◽  
Epidemiological Data ◽  
Risk Of Bias ◽  
Published Data ◽  
Language Restriction ◽  
Ethical Approval ◽  
Meta Analyses ◽  
The Impact

IntroductionCOVID-19 has spread rapidly in China and around the world. Published studies have revealed that some patients with COVID-19 had abnormal liver function in laboratory tests. However, the results were inconsistent and the analysis of epidemiological data stratified by the severity of COVID-19 was not available in previous meta-analyses. Furthermore, these meta-analyses were suspected of overestimating the incidence of liver injury in patients with COVID-19 because some studies considered transaminase elevation as liver injury, which might partially result from cardiac and muscle injury. This systematic review aims to enrol published literatures related to COVID-19 without language restriction, analyse the data based on the severity of the COVID-19 and explore the impact of varied definitions of liver injury on the incidence of liver injury.Methods and analysisWe have conducted a preliminary search on PubMed and Excerpta Medica Database on 13 April 2020, for the studies published after December 2019 on the prevalence of acute liver injury and hypertransaminemia in patients with COVID-19. Two reviewers will independently screen studies, extract data and assess the risk of bias. We will estimate the pooled incidence of hypertransaminemia and acute liver injury in patients with COVID-19 by using the random-effects model. The I² test will be used to identify the extent of heterogeneity. Publication bias will be assessed by funnel plot and performing the Begg’s and Egger’s test if adequate studies are available. We will perform a risk of bias assessment using the Joanna Briggs Institute’s critical appraisal checklist.Ethics and disseminationSince this study will be based on the published data, it does not require ethical approval. The final results of this study will be published in a peer-reviewed journal.PROSPERO registration numberCRD42020179462.

scholarly journals Systematic Review and Meta-Analysis: Macrolides- and Amoxicillin/Clavulanate-induced Acute Liver Injury

2016 ◽  
Vol 119 (1) ◽  
pp. 3-9 ◽  
Author(s):  
Pili Ferrer ◽  
Justyna Amelio ◽  
Elena Ballarín ◽  
Mònica Sabaté ◽  
Xavi Vidal ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Injury ◽  
Acute Liver Injury ◽  
Meta Analysis ◽  
Amoxicillin Clavulanate

scholarly journals Role of Ursodeoxycholic Acid in Treating and Preventing Idiosyncratic Drug-Induced Liver Injury. A Systematic Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Mercedes Robles-Díaz ◽  
Lana Nezic ◽  
Vesna Vujic-Aleksic ◽  
Einar S. Björnsson
Keyword(s):  
Systematic Review ◽  
Liver Injury ◽  
Ursodeoxycholic Acid ◽  
Randomized Clinical Trials ◽  
Case Reports ◽  
Lower Percentage ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Treatment And Prevention

Introduction: Treatment is generally not available for drug-induced liver injury (DILI) patients except in some specific circumstances. The management of DILI is based on the withdrawal of the responsible drug and monitoring the patients and only a few patients need to be referred to a transplant center. Some studies on the role of ursodeoxycholic acid (UDCA) in DILI have been published. The aim of this study was to perform a systematic review of the role of UDCA in the treatment and prevention of DILI.Methods: A search was undertaken in PubMed, with the key words ursodeoxycholic acid, drug-induced liver injury and hepatotoxicity following the PRISMA guidelines.Results: A total of 33 publications were identified: 25 case reports and 8 case series. In 18 of the 25 cases reports (22 patients), authors reported improvement of liver injury associated with UDCA therapy whereas 7 case reports did not show clinical or biochemical improvement after UDCA treatment. There were 4 studies evaluating the role of UDCA in the treatment of DILI, three prospective (one being a clinical trial) and one retrospective studies. Three studies observed liver profile improvements associated with UDCA. In addition, four studies evaluated UDCA in the prevention of DILI: one pilot study, two randomized clinical trials (RCT) and one retrospective study. Three of these studies observed a lower percentage of patients with an increase in transaminases in the groups that used UDCA for DILI prevention.Conclusion: According to available data UDCA seems to have some benefits in the treatment and prevention of DILI. However, the design of the published studies does not allow a firm conclusion to be drawn on the efficacy of UDCA in DILI. A well designed RCT to evaluate the role of UDCA in DILI is needed.

Acute liver failure after changing oral anticoagulant from apixaban to rivaroxaban

2021 ◽  
Vol 14 (4) ◽  
pp. e240719
Author(s):  
Vikram Rao ◽  
Anna Munasinghe
Keyword(s):  
Adverse Reaction ◽  
Liver Injury ◽  
Liver Failure ◽  
Acute Liver Injury ◽  
Case Reports ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Treatment And Prevention ◽  
Elevated Bilirubin ◽  
Liver Transaminases

Rivaroxaban is a commonly used anticoagulant agent for treatment and prevention of thromboembolism. There are case reports demonstrating an association between its use and drug-induced liver injury. However, this has not been reported in a patient who previously tolerated apixaban. An 88-year-old man presented to hospital with worsening lethargy, jaundice and vomiting. He had severely elevated liver transaminases, an abnormal coagulation profile and elevated bilirubin in keeping with acute liver injury. This is in the context of having had his anticoagulation medication switched from apixaban to rivaroxaban 2 weeks prior. The patient recovered well after cessation of rivaroxaban, suggesting that it was the likely offending agent. The mechanism of rivaroxaban-induced liver injury remains to be investigated. Drug-induced liver injury should be discussed and monitored for as a potential adverse reaction when commencing rivaroxaban, even if a patient has previously tolerated a drug of the same class.

Antibiotic-Associated Hepatitis: Update from 1990

1997 ◽  
Vol 31 (2) ◽  
pp. 204-220 ◽  
Author(s):  
Thierry Vial ◽  
Michel Biour ◽  
Jacques Descotes ◽  
Christian Trepo
Keyword(s):  
Bile Duct ◽  
Liver Injury ◽  
Acute Liver Injury ◽  
Case Reports ◽  
Data Extraction ◽  
Epidemiologic Studies ◽  
Bile Duct Injuries ◽  
Study Selection ◽  
Other Information ◽  
Clinical Description

Objective To review the literature on the recent available evidence of antibiotic-associated acute liver injury. Data Sources All published articles from January 1990 to July 1995 were extracted from the monthly updated HEPATOX database. Additional articles were found using MEDLINE, EMBASE, and PASCAL searches. Hepatic injuries associated with antituberculous, antimycotic, antiviral, antiprotozoal, and antiseptic compounds were excluded from this review. Study Selection As the amount of literature was large, only case reports, series, and epidemiologic data were used. Results from clinical trials were reviewed only when no other information was available. Data Extraction Original articles were reviewed to select relevant material. Information regarding the clinical description, histologic features, severity, outcome, and possible risk factors was extracted. Data on incidence were provided by epidemiologic studies or spontaneous reporting to regulatory agencies. Data Synthesis Antibiotic-associated acute liver injury is rare, with an incidence not exceeding 1 case per 10 000 users for most drugs. Among beta-lactams, amoxicillin/clavulanic acid and penicillinase-resistant penicillins are associated with predominant and sometimes protracted cholestasis. The hepatotoxic potential of all available erythromycin salts is confirmed, and recent evidence suggests that roxithromycin could be added to the list of antibiotic-induced liver injury. Among fluoroquinolones, only ciprofloxacin has been associated with serious hepatitis. Trimethoprim/sulfamethoxazole-induced hepatitis is often reported, but trimethoprim alone also appears as a possible cause of acute liver injury. Finally, acute bile duct injuries and ductopenia have been described with several antibiotics. Conclusions The most important recent information is the possibility of protracted liver cholestasis with bile duct injuries induced by several antibiotics, particularly penicillinase-resistant penicillins, and the identification of new potentially hepatotoxic antibiotics, namely, roxithromycin, ciprofloxacin, and trimethoprim.

scholarly journals The prevalence, predictors and outcomes of acute liver injury among patients with COVID‐19: A systematic review and meta‐analysis

2021 ◽  
Author(s):  
Harapan Harapan ◽  
Jonny Karunia Fajar ◽  
Supriono Supriono ◽  
Gatot Soegiarto ◽  
Laksmi Wulandari ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Injury ◽  
Acute Liver Injury ◽  
Meta Analysis

scholarly journals Clozapine-induced liver injury and pleural effusion

2014 ◽  
Vol 6 (2) ◽  
Author(s):  
Joseph P.M. Kane ◽  
Francis A. O’Neill
Keyword(s):  
Pleural Effusion ◽  
Liver Injury ◽  
Liver Enzymes ◽  
Clinical Symptoms ◽  
Acute Liver Injury ◽  
Case Reports ◽  
High Index ◽  
Documented Case ◽  
High Index Of Suspicion ◽  
Symptoms And Signs

Clozapine, whilst associated commonly with a transient and benign increase in liver enzymes, has also been associated with varying presentations of hepatitis in existing case reports. This report describes what we believe to be the first documented case of acute liver injury and pleural effusion associated with clozapine, resolving after cessation of the agent. The case supports existing literature in advocating a high index of suspicion, particularly in the 4-5 weeks following clozapine initiation, when considering nonspecific clinical symptoms and signs.

scholarly journals N-acetyl cysteine versus standard of care for non-acetaminophen induced acute liver injury: a systematic review and meta-analysis

2021 ◽  
Vol 24 ◽  
pp. 100340
Author(s):  
Dhan Bahadur Shrestha ◽  
Pravash Budhathoki ◽  
Yub Raj Sedhai ◽  
Anurag Adhikari ◽  
Ayusha Poudel ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Injury ◽  
Acute Liver Injury ◽  
Meta Analysis ◽  
Standard Of Care ◽  
Acetyl Cysteine
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