scholarly journals The prevalence, predictors and outcomes of acute liver injury among patients with COVID‐19: A systematic review and meta‐analysis

2021 ◽  
Author(s):  
Harapan Harapan ◽  
Jonny Karunia Fajar ◽  
Supriono Supriono ◽  
Gatot Soegiarto ◽  
Laksmi Wulandari ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Injury ◽  
Acute Liver Injury ◽  
Meta Analysis

scholarly journals Systematic Review and Meta-Analysis: Macrolides- and Amoxicillin/Clavulanate-induced Acute Liver Injury

2016 ◽  
Vol 119 (1) ◽  
pp. 3-9 ◽  
Author(s):  
Pili Ferrer ◽  
Justyna Amelio ◽  
Elena Ballarín ◽  
Mònica Sabaté ◽  
Xavi Vidal ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Injury ◽  
Acute Liver Injury ◽  
Meta Analysis ◽  
Amoxicillin Clavulanate

scholarly journals N-acetyl cysteine versus standard of care for non-acetaminophen induced acute liver injury: a systematic review and meta-analysis

2021 ◽  
Vol 24 ◽  
pp. 100340
Author(s):  
Dhan Bahadur Shrestha ◽  
Pravash Budhathoki ◽  
Yub Raj Sedhai ◽  
Anurag Adhikari ◽  
Ayusha Poudel ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Injury ◽  
Acute Liver Injury ◽  
Meta Analysis ◽  
Standard Of Care ◽  
Acetyl Cysteine

scholarly journals Prevention and management of idiosyncratic drug-induced liver injury: Systematic review and meta-analysis of randomised clinical trials

2021 ◽  
Vol 164 ◽  
pp. 105404
Author(s):  
Hao Niu ◽  
Judith Sanabria-Cabrera ◽  
Ismael Alvarez-Alvarez ◽  
Mercedes Robles-Diaz ◽  
Simona Stankevičiūtė ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Liver Injury ◽  
Meta Analysis ◽  
Randomised Clinical Trials ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals Crimean‐Congo hemorrhagic fever‐induced liver injury: a systematic review and meta‐analysis

2021 ◽  
Author(s):  
Sawai Singh Rathore ◽  
Ade Harrison Manju ◽  
Qingqing Wen ◽  
Manush Sondhi ◽  
Reshma Pydi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Injury ◽  
Meta Analysis ◽  
Hemorrhagic Fever ◽  
Crimean Congo Hemorrhagic Fever

Mesenchymal Stem Cell Therapy for Acetaminophen-Related Liver Injury: A Systematic Review and Meta-Analysis of Experimental Studies in Vivo

2021 ◽  
Vol 16 ◽  
Author(s):  
Li Wang ◽  
Yiwen Zhang ◽  
Jiajun Zhong ◽  
Yuan Zhang ◽  
Shuisheng Zhou ◽  
...  
Keyword(s):  
Systematic Review ◽  
Stem Cell ◽  
Liver Injury ◽  
Mesenchymal Stem Cell ◽  
Small Sample Size ◽  
Meta Analysis ◽  
Experimental Studies ◽  
Small Sample ◽  
Control Group

Objective: The efficacy of mesenchymal stem cell (MSC) therapy in acetaminophen-induced liver injury has been investigated in animal experiments, but individual studies with a small sample size cannot be used to draw a clear conclusion. Therefore, we conducted a systematic review and meta-analysis of preclinical studies to explore the potential of using MSCs in acetaminophen-induced liver injury. Methods: Eight databases were searched for studies reporting the effects of MSCs on acetaminophen hepatoxicity. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines were used. SYRCLE’s risk of bias tool for animal studies was applied to assess the methodological quality. A meta-analysis was performed by using RevMan 5.4 and STATA/SE 16.0 software. Results: Eleven studies involving 159 animals were included according to PRISMA statement guidelines. Significant associations were found for MSCs with the levels of alanine transaminase (ALT) (standardized mean difference (SMD) − 2.58, p < 0.0001), aspartate aminotransferase (AST) (SMD − 1.75, p = 0.001), glutathione (GSH) (SMD 3.7, p < 0.0001), superoxide dismutase (SOD) (SMD 1.86, p = 0.022), interleukin 10 (IL-10) (SMD 5.14, p = 0.0002) and tumor necrosis factor-α (TNF-α) (SMD − 4.48, p = 0.011) compared with those in the control group. The subgroup analysis showed that the tissue source of MSCs significantly affected the therapeutic efficacy (p < 0.05). Conclusion: Our meta-analysis results demonstrate that MSCs could be a potential treatment for acetaminophen-related liver injury.

scholarly journals COVID-19, MERS and SARS with Concomitant Liver Injury—Systematic Review of the Existing Literature

2020 ◽  
Vol 9 (5) ◽  
pp. 1420 ◽  
Author(s):  
Michał Kukla ◽  
Karolina Skonieczna-Żydecka ◽  
Katarzyna Kotfis ◽  
Dominika Maciejewska ◽  
Igor Łoniewski ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Injury ◽  
Clinical Course ◽  
Meta Analysis ◽  
Gastrointestinal Symptoms ◽  
Intensive Care Treatment ◽  
The Novel ◽  
Massive Necrosis ◽  
Novel Coronavirus ◽  
Elevated Transaminases

The novel coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection has been predominantly linked to respiratory distress syndrome, but gastrointestinal symptoms and hepatic injury have also been reported. The mechanism of liver injury is poorly understood and may result as a consequence of viral hepatitis, systemic inflammatory response, gut barrier and microbiome alterations, intensive care treatment or drug toxicity. The incidence of hepatopathy among patients with coronavirus disease 2019 (COVID-19) is unclear, but studies have reported liver injury in patients with SARS and Middle East respiratory syndrome (MERS). We aimed to systematically review data on the prevalence of hepatic impairments and their clinical course in SARS and MERS Coronaviridae infections. A systematic literature search (PubMed/Embase/Cinahl/Web of Science) according to preferred reporting items for systematic review and meta-analysis protocols (PRISMA) was conducted from database inception until 17/03/2020 for studies that evaluated the incidence of hepatic abnormalities in SARS CoV-1, SARS CoV-2 and MERS infected patients with reported liver-related parameters. A total of forty-three studies were included. Liver anomalies were predominantly mild to moderately elevated transaminases, hypoalbuminemia and prolongation of prothrombin time. Histopathology varied between non-specific inflammation, mild steatosis, congestion and massive necrosis. More studies to elucidate the mechanism and importance of liver injury on the clinical course and prognosis in patients with novel SARS-CoV-2 infection are warranted.

Sa1558 Risk of Non-Steroidal Anti-Inflammatory Drugs-Related Serious Drug-Induced Liver Injury: A Systematic Review and Meta-Analysis

2016 ◽  
Vol 150 (4) ◽  
pp. S1066
Author(s):  
Sakkarin Chirapongsathorn ◽  
Chayakrit Krittanawong ◽  
Ann M. Farrell ◽  
Mohammad H. Murad ◽  
Patrick Kamath
Keyword(s):  
Systematic Review ◽  
Liver Injury ◽  
Meta Analysis ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Digestive symptoms and liver injury in patients with coronavirus disease 2019 ( COVID ‐19): A systematic review with meta‐analysis

JGH Open ◽  
2020 ◽  
Vol 4 (6) ◽  
pp. 1047-1058
Author(s):  
Jian Wan ◽  
Xuan Wang ◽  
Song Su ◽  
Yujie Zhang ◽  
Yirong Jin ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Injury ◽  
Meta Analysis

Systematic review of severe acute liver injury caused by terbinafine

2014 ◽  
Vol 36 (4) ◽  
pp. 679-683 ◽  
Author(s):  
Jun Yan ◽  
Xiaolin Wang ◽  
Shengli Chen
Keyword(s):  
Systematic Review ◽  
Liver Injury ◽  
Acute Liver Injury
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