scholarly journals Stable isotope-labelled intravenous microdose for absolute bioavailability and effect of grapefruit juice on ibrutinib in healthy adults

2016 ◽  
Vol 81 (2) ◽  
pp. 235-245 ◽  
Author(s):  
Ronald de Vries ◽  
Johan W. Smit ◽  
Peter Hellemans ◽  
James Jiao ◽  
Joseph Murphy ◽  
...  
Keyword(s):  
Stable Isotope ◽  
Grapefruit Juice ◽  
Healthy Adults ◽  
Absolute Bioavailability

scholarly journals Oral Bioavailability and Pharmacokinetics of Trovafloxacin in Patients with AIDS

1999 ◽  
Vol 43 (12) ◽  
pp. 3005-3007 ◽  
Author(s):  
Melinda K. Lacy ◽  
David P. Nicolau ◽  
Charles H. Nightingale ◽  
Amy Geffken ◽  
Renli Teng ◽  
...  
Keyword(s):  
Oral Bioavailability ◽  
Active Form ◽  
Healthy Adults ◽  
Absolute Bioavailability ◽  
Randomized Design ◽  
The Mean

ABSTRACT Trovafloxacin pharmacokinetics were evaluated in 12 subjects with AIDS. By using a randomized design, single 200-mg doses of oral trovafloxacin and intravenous alatrofloxacin were administered. The mean absolute bioavailability was 91%. The pharmacokinetics of trovafloxacin when administered orally as the active form or intravenously as the prodrug (alatrofloxacin) are not altered in subjects with AIDS compared to those in healthy adults.

Furocoumarin Kinetics in Plasma and Urine of Healthy Adults Following Consumption of Grapefruit (Citrus paradisi Macf.) and Grapefruit Juice

2017 ◽  
Vol 65 (14) ◽  
pp. 3006-3012 ◽  
Author(s):  
Melissa M. Melough ◽  
Terrence M. Vance ◽  
Sang Gil Lee ◽  
Anthony A. Provatas ◽  
Christopher Perkins ◽  
...  
Keyword(s):  
Grapefruit Juice ◽  
Healthy Adults ◽  
Citrus Paradisi

Selenium metabolism in healthy adults: quantitative aspects using the stable isotope 74SeO32-

1982 ◽  
Vol 35 (4) ◽  
pp. 647-654 ◽  
Author(s):  
M Janghorbani ◽  
M J Christensen ◽  
A Nahapetian ◽  
V R Young
Keyword(s):  
Stable Isotope ◽  
Healthy Adults ◽  
Selenium Metabolism

Absolute Bioavailability of Osimertinib in Healthy Adults

2018 ◽  
Vol 8 (2) ◽  
pp. 198-207 ◽  
Author(s):  
Karthick Vishwanathan ◽  
Karen So ◽  
Karen Thomas ◽  
Alex Bramley ◽  
Stephen English ◽  
...  
Keyword(s):  
Healthy Adults ◽  
Absolute Bioavailability

scholarly journals Injectable Dexamethasone Sodium Phosphate Administered Orally? A Pharmacokinetic Analysis of a Common Emergency Department Practice

2015 ◽  
Vol 20 (2) ◽  
pp. 105-111
Author(s):  
Alexander Toledo ◽  
Christopher S. Amato ◽  
Nigel Clarke ◽  
Richard E. Reitz ◽  
David Salo
Keyword(s):  
Sodium Phosphate ◽  
Area Under The Curve ◽  
Relative Bioavailability ◽  
Healthy Adults ◽  
Absolute Bioavailability ◽  
Pharmacokinetic Analysis ◽  
Pharmacokinetic Data ◽  
Open Label ◽  
Dexamethasone Sodium Phosphate ◽  
The Mean

BACKGROUND: The injectable formulation of dexamethasone has been administered orally, for the treatment of pediatric asthma and croup. The practice is followed in emergency departments around the country, but pharmacokinetic data supporting this practice are lacking. OBJECTIVES: This study evaluated the relative bioavailability and pharmacokinetics of dexamethasone sodium phosphate for injection (DSPI) administered orally compared to dexamethasone oral concentrate (DOC) in healthy adults. METHODS: This was an open label, crossover study of 11 healthy adults 18 to 45 years of age. All subjects received 8 mg of dexamethasone oral concentrate initially. After a 1-week wash-out period, subjects received 8 mg of DSPI administered orally. Dexamethasone levels were measured by liquid chromatography in tandem mass spectrometry. Cmax and area under the curve (AUC (0-t) and AUC (0-∞)) were calculated and compared between groups using the paired t test. RESULTS: The mean ± SD AUC(0-t) for dexamethasone oral concentrate and DSPI were 5497.23 ± 1649 and 4807.82 ± 1971) ng/dL/hr, respectively; 90% confidence interval (CI) was 78.8%–96.9%. The mean ± SD AUC(0-∞) for dexamethasone oral concentrate and DSPI were 6136.43 ± 2577 and 5591.48 ± 3075 ng/dL/hr, respectively; 90% CI was 79.0% –105.2%. Mean Cmax ± SD for DOC and DSPI were 942.94 ± 151 and 790.92 ± 229 ng/dL, respectively; 90% CI 76.8%–91.7%. The relative bioavailability of DSPI administered orally was 87.4% when using AUC(0-t) and 91.1% when using AUC(0-∞). The calculated absolute bioavailability was 75.9%. CONCLUSIONS: DSPI is not bioequivalent to dexamethasone oral concentrate when administered orally. The existing literature supports the efficacy of DSPI despite this. Dosing adjustments may be considered.

Absolute bioavailability in man of N-acetylprocainamide determined by a novel stable isotope method

1975 ◽  
Vol 18 (5part1) ◽  
pp. 613-622 ◽  
Author(s):  
John M. Strong ◽  
John S. Dutcher ◽  
Woong-Ku Lee ◽  
Arthur J. Atkinson
Keyword(s):  
Stable Isotope ◽  
Absolute Bioavailability ◽  
Isotope Method

Lack of a clinically significant interaction of grapefruit juice with ambrisentan and bosentan in healthy adults

2014 ◽  
Vol 52 (11) ◽  
pp. 957-964 ◽  
Author(s):  
Christoph Markert ◽  
Theresia Wirsching ◽  
Regina Hellwig ◽  
Jürgen Burhenne ◽  
Johanna Weiss ◽  
...  
Keyword(s):  
Significant Interaction ◽  
Grapefruit Juice ◽  
Healthy Adults ◽  
Clinically Significant
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