Absolute Bioavailability of Osimertinib in Healthy Adults

2018 ◽  
Vol 8 (2) ◽  
pp. 198-207 ◽  
Author(s):  
Karthick Vishwanathan ◽  
Karen So ◽  
Karen Thomas ◽  
Alex Bramley ◽  
Stephen English ◽  
...  
Keyword(s):  
Healthy Adults ◽  
Absolute Bioavailability

scholarly journals Oral Bioavailability and Pharmacokinetics of Trovafloxacin in Patients with AIDS

1999 ◽  
Vol 43 (12) ◽  
pp. 3005-3007 ◽  
Author(s):  
Melinda K. Lacy ◽  
David P. Nicolau ◽  
Charles H. Nightingale ◽  
Amy Geffken ◽  
Renli Teng ◽  
...  
Keyword(s):  
Oral Bioavailability ◽  
Active Form ◽  
Healthy Adults ◽  
Absolute Bioavailability ◽  
Randomized Design ◽  
The Mean

ABSTRACT Trovafloxacin pharmacokinetics were evaluated in 12 subjects with AIDS. By using a randomized design, single 200-mg doses of oral trovafloxacin and intravenous alatrofloxacin were administered. The mean absolute bioavailability was 91%. The pharmacokinetics of trovafloxacin when administered orally as the active form or intravenously as the prodrug (alatrofloxacin) are not altered in subjects with AIDS compared to those in healthy adults.

scholarly journals Stable isotope-labelled intravenous microdose for absolute bioavailability and effect of grapefruit juice on ibrutinib in healthy adults

2016 ◽  
Vol 81 (2) ◽  
pp. 235-245 ◽  
Author(s):  
Ronald de Vries ◽  
Johan W. Smit ◽  
Peter Hellemans ◽  
James Jiao ◽  
Joseph Murphy ◽  
...  
Keyword(s):  
Stable Isotope ◽  
Grapefruit Juice ◽  
Healthy Adults ◽  
Absolute Bioavailability

scholarly journals Injectable Dexamethasone Sodium Phosphate Administered Orally? A Pharmacokinetic Analysis of a Common Emergency Department Practice

2015 ◽  
Vol 20 (2) ◽  
pp. 105-111
Author(s):  
Alexander Toledo ◽  
Christopher S. Amato ◽  
Nigel Clarke ◽  
Richard E. Reitz ◽  
David Salo
Keyword(s):  
Sodium Phosphate ◽  
Area Under The Curve ◽  
Relative Bioavailability ◽  
Healthy Adults ◽  
Absolute Bioavailability ◽  
Pharmacokinetic Analysis ◽  
Pharmacokinetic Data ◽  
Open Label ◽  
Dexamethasone Sodium Phosphate ◽  
The Mean

BACKGROUND: The injectable formulation of dexamethasone has been administered orally, for the treatment of pediatric asthma and croup. The practice is followed in emergency departments around the country, but pharmacokinetic data supporting this practice are lacking. OBJECTIVES: This study evaluated the relative bioavailability and pharmacokinetics of dexamethasone sodium phosphate for injection (DSPI) administered orally compared to dexamethasone oral concentrate (DOC) in healthy adults. METHODS: This was an open label, crossover study of 11 healthy adults 18 to 45 years of age. All subjects received 8 mg of dexamethasone oral concentrate initially. After a 1-week wash-out period, subjects received 8 mg of DSPI administered orally. Dexamethasone levels were measured by liquid chromatography in tandem mass spectrometry. Cmax and area under the curve (AUC (0-t) and AUC (0-∞)) were calculated and compared between groups using the paired t test. RESULTS: The mean ± SD AUC(0-t) for dexamethasone oral concentrate and DSPI were 5497.23 ± 1649 and 4807.82 ± 1971) ng/dL/hr, respectively; 90% confidence interval (CI) was 78.8%–96.9%. The mean ± SD AUC(0-∞) for dexamethasone oral concentrate and DSPI were 6136.43 ± 2577 and 5591.48 ± 3075 ng/dL/hr, respectively; 90% CI was 79.0% –105.2%. Mean Cmax ± SD for DOC and DSPI were 942.94 ± 151 and 790.92 ± 229 ng/dL, respectively; 90% CI 76.8%–91.7%. The relative bioavailability of DSPI administered orally was 87.4% when using AUC(0-t) and 91.1% when using AUC(0-∞). The calculated absolute bioavailability was 75.9%. CONCLUSIONS: DSPI is not bioequivalent to dexamethasone oral concentrate when administered orally. The existing literature supports the efficacy of DSPI despite this. Dosing adjustments may be considered.

Wechsler Memory Scale, Rivermead Behavioral Memory Test, and Everyday Memory Questionnaire in Healthy Adults and Alzheimer Patients

2002 ◽  
Vol 18 (1) ◽  
pp. 63-77 ◽  
Author(s):  
Anastasia Efklides ◽  
Efterpi Yiultsi ◽  
Theopisti Kangellidou ◽  
Fotini Kounti ◽  
Fotini Dina ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Semantic Memory ◽  
Memory Test ◽  
Healthy Adults ◽  
Gender Effects ◽  
Everyday Memory ◽  
Wechsler Memory Scale ◽  
Everyday Memory Questionnaire ◽  
Behavioral Memory ◽  
Memory Questionnaire

Summary: The Wechsler Memory Scale (WMS) is a laboratory-based memory test that has been criticized for its lack of ecological validity and for not testing long-term memory. A more recent memory test, which aims at testing everyday memory, is the Rivermead Behavioral Memory Test (RBMT); it tests prospective memory and other forms of memory not tapped by WMS. However, even this test does not capture all aspects of everyday memory problems often reported by adults. These problems are the object of the Everyday Memory Questionnaire (EMQ). This study aimed at identifying the relationships between these three memory tests. The differential effect of Alzheimer's disease (AD) on the above relationships was also studied. The sample consisted of 233 healthy adults (20 to 75+ years of age) and 39 AD patients (50 to 75 years of age). Confirmatory factor analysis revealed the following latent factors: Verbal Memory, Visual Reconstruction, Orientation, Message (action embedded in spatial context), Visual Recognition, Spatial Memory, New Learning/Association Forming, Prospective/Episodic Memory, and Metamemory. These first-order factors were further explained by two second-order factors: Semantic Memory and Coordination of Semantic and Visuo-Spatial Memory. This basic structure was preserved in the sample of AD patients, although AD patients performed less well on the WMS and the RBMT. Some interesting findings regarding semantic memory, face recognition, and metamemory in AD patients are also reported. Age, education, but no gender effects on memory performance were also detected.

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