scholarly journals Editorial: importance of an elevated mean platelet volume for prediction of major adverse cardiovascular events in non-alcoholic fatty liver disease

2019 ◽  
Vol 49 (8) ◽  
pp. 1092-1093 ◽  
Author(s):  
Giovanni Targher ◽  
Giuseppe Lippi
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Mean Platelet Volume ◽  
Fatty Liver Disease ◽  
Cardiovascular Events ◽  
Major Adverse Cardiovascular Events ◽  
Platelet Volume ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease and incident major adverse cardiovascular events: results from a nationwide histology cohort

Gut ◽  
2021 ◽  
pp. gutjnl-2021-325724
Author(s):  
Tracey G Simon ◽  
Bjorn Roelstraete ◽  
Hannes Hagström ◽  
Johan Sundström ◽  
Jonas F Ludvigsson
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Cardiovascular Events ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Major Adverse Cardiovascular Events ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease ◽  
Population Controls

ObjectiveSome data suggest a positive association between non-alcoholic fatty liver disease (NAFLD) and incident major adverse cardiovascular events (MACEs). However, data are lacking from large cohorts with liver histology, which remains the gold standard for staging NAFLD severity.DesignThis population-based cohort included all Swedish adults with histologically confirmed NAFLD and without cardiovascular disease (CVD) at baseline (1966–2016, n=10 422). NAFLD was defined from prospectively recorded histopathology and categorised as simple steatosis, non-fibrotic steatohepatitis, non-cirrhotic fibrosis and cirrhosis. Patients with NAFLD were matched to ≤5 population controls without NAFLD or CVD, by age, sex, calendar year and county (n=46 517). Using Cox proportional hazards modelling, we calculated multivariable adjusted HRs (aHRs) and 95% CIs for MACE outcomes (ie, ischaemic heart disease (IHD), stroke, congestive heart failure (CHF) or cardiovascular (CV) mortality).ResultsOver a median of 13.6 years, incident MACE was confirmed in 2850 patients with NAFLD and 10 648 controls. Patients with NAFLD had higher incidence of MACE than controls (24.3 vs 16.0/1000 person-years (PY); difference=8.3/1000 PY; aHR 1.63, 95% CI 1.56 to 1.70), including higher rates of IHD (difference=4.2/1000 PY; aHR 1.64, 95% CI 1.54 to 1.75), CHF (difference=3.3/1000 PY; aHR 1.75, 95% CI 1.63 to 1.87), stroke (difference=2.4/1000 PY; aHR 1.58, 95% CI 1.46 to 1.71) and CV mortality (difference=1.2/1000 PY; aHR 1.37, 95% CI 1.27 to 1.48). Rates of incident MACE increased progressively with worsening NAFLD severity (ptrend=0.02), with the highest incidence observed with cirrhosis (difference vs controls=27.2/1000 PY; aHR 2.15, 95% CI 1.77 to 2.61).ConclusionCompared with matched population controls, patients with biopsy-proven NAFLD had significantly higher incidence of MACE, including IHD, stroke, CHF and CV mortality. Excess risk was evident across all stages of NAFLD and increased with worsening disease severity.

Mean platelet volume in biopsy-proven non-alcoholic fatty liver disease

Platelets ◽  
2012 ◽  
Vol 24 (3) ◽  
pp. 194-199 ◽  
Author(s):  
Mehmet Celikbilek ◽  
Sebnem Gürsoy ◽  
Kemal Deniz ◽  
Ahmet Karaman ◽  
Gökmen Zararsiz ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Mean Platelet Volume ◽  
Fatty Liver Disease ◽  
Platelet Volume ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease
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