scholarly journals Editorial: surviving your genes-the role of PNPLA3 variation in end-stage liver disease. Authors’ reply

2018 ◽  
Vol 48 (7) ◽  
pp. 775-776
Author(s):  
Mattias Mandorfer ◽  
Bernhard Scheiner ◽  
Thomas Reiberger ◽  
Arnulf Ferlitsch ◽  
Keyword(s):  
Liver Disease ◽  
End Stage Liver Disease ◽  
End Stage

Glomerular injury in end-stage liver disease — role of circulating IgG and IgM immune complexes

1993 ◽  
Vol 7 (1) ◽  
pp. 6-10 ◽  
Author(s):  
Lawrence S. Milner ◽  
Mark T. Houser ◽  
Peter C. Kolbeck ◽  
Dean L. Antonson ◽  
Thomas L. McDonald ◽  
...  
Keyword(s):  
Liver Disease ◽  
Immune Complexes ◽  
Glomerular Injury ◽  
End Stage Liver Disease ◽  
End Stage

The Role of Model of End-Stage Liver Disease Score in Predicting Outcomes of Carotid Endarterectomy in Patients with Liver Disease

2015 ◽  
Vol 221 (4) ◽  
pp. S185-S186
Author(s):  
Brianna M. Krafcik ◽  
Denis Rybin ◽  
Gheorghe Doros ◽  
Mohammed H. Eslami ◽  
Alik Farber ◽  
...  
Keyword(s):  
Liver Disease ◽  
Carotid Endarterectomy ◽  
Disease Score ◽  
End Stage Liver Disease ◽  
End Stage

scholarly journals The role of Model for End-Stage Liver Disease (MELD) score in predicting outcomes for lower extremity bypass

2016 ◽  
Vol 64 (1) ◽  
pp. 124-130 ◽  
Author(s):  
Brianna M. Krafcik ◽  
Alik Farber ◽  
Mohammad H. Eslami ◽  
Jeffrey A. Kalish ◽  
Denis Rybin ◽  
...  
Keyword(s):  
Liver Disease ◽  
Lower Extremity ◽  
Meld Score ◽  
End Stage Liver Disease ◽  
End Stage

THE ROLE OF INHALED NITRIC OXIDE IN END-STAGE LIVER DISEASE

1998 ◽  
Vol 89 (Supplement) ◽  
pp. 420A
Author(s):  
M A E Ramsay ◽  
K Lynch ◽  
H A T Hein ◽  
K Ramsay ◽  
R I Simpson ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Liver Disease ◽  
Inhaled Nitric Oxide ◽  
End Stage Liver Disease ◽  
End Stage

CD133+ Pluripotent Stem Cells for the Treatment of Chronic Liver Failure.

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 1185-1185
Author(s):  
Lucia Catani ◽  
Stefania Lorenzini ◽  
Rosaria Giordano ◽  
Paolo Caraceni ◽  
Maria Rosa Motta ◽  
...  
Keyword(s):  
Stem Cells ◽  
Liver Cirrhosis ◽  
Liver Disease ◽  
Mononuclear Cells ◽  
Conflicts Of Interest ◽  
Chronic Liver ◽  
Peripheral Blood Stem Cells ◽  
End Stage Liver Disease ◽  
End Stage

Abstract Abstract 1185 Background. The potential role of bone marrow (BM)-derived stem cells (SCs) in patients with end-stage liver disease has been addressed by our group in four studies. Main objectives were: 1) to assess stem/progenitor cell mobilization in 24 patients receiving orthotopic liver transplantation (OLT); 2) to evaluate whether G-CSF can be safely administered to patients with liver cirrhosis in order to expand and mobilize BM-derived SCs; 3) to investigate the effects of transplantation of human G-CSF-mobilized CD34+ and CD133+ SCs in mice with chronic liver injury and fibrosis; 4) to evaluate the feasibility and the safety of the purification and intrahepatic reinfusion of increasing numbers of autologous BM-derived G-CSF-mobilized CD133+ SCs in patients with end-stage liver disease. Methods. 1) Flow cytometry analysis, clonogenic assays and RT-PCR have been performed after OLT; 2) 18 patients with advanced liver disease were consecutively treated with increasing doses of G-CSF starting from 2 μg/kg/daily; 3) C57BL/6N mice received CCl4 by inhalation for thirteen weeks and were treated with Cyclosporin-A. Transplantation was performed by injection (tail vein) of 106 CD34+ or CD133+ SCs of three cirrhotic patients. After four weeks from transplantation all mice were sacrificed; 4) G-CSF at 7.5μg/Kg/b.i.d. is administered subcutaneosly (sc) from day 1 until the completion of peripheral blood stem cells (PBSC) collection. Collection of PBSC will begin on day + 4 only if the concentration of CD133+ cells is 38/mL. PB mononuclear cells obtained from mobilized standard-volume leukapheresis will be incubated with Macs colloidal superparamagnetic CD133 microbeads. CliniMacs device is used for the positive selection of CD133+ SCs under GMP conditions. At least 4 weeks after SC mobilization, collection and cryopreservation, highly purified autologous G-CSF-mobilized CD133+ cells are re-infused through the hepatic artery by transfemoral or transbranchial arteriography. CD133+ cells are administered to patients starting from 5×104/Kg patient's body weight and increased every 3 patients. The maximum infused cell dose will be 1×106/kg. G-CSF at 5μg/Kg/day is administered sc for 3 days after the reinfusion of SCs for their expansion and to induce a selective proliferative advantage of reinfused cells in vivo. Results and Discussion. 1) We demonstrated that both early subsets of the hematopoietic SC compartment (CD34+/CD90+ cells) and more mature committed progenitors (CFU-C) were mobilized into PB after OLT. We also demonstrated the release from the BM of liver-committed HSCs co-expressing epithelial markers after OLT; 2) We show that the administration of G-CSF to patients with liver cirrhosis is safe and feasible and allows the mobilization and collection of BM-derived SCs at the dose of 15 mg/kg/day. 3) We demonstrated that mice transplanted with either CD133+ or CD34+ human cells appear to have less fibrotic septa than mice without SC transplantation, suggesting the potential therapeutic role of human SCs on the recovery of liver fibrosis. 4) Up to date, three patients with end stage liver disease have been successfully mobilized with G-CSF and highly purified autologous CD133+ SCs have been re-infused. The number of collected CD133+ SCs is 0,7, 0,2 and 0.35×106/Kg, respectively. The number of the re-infused highly purified CD133+ SCs is 4.7, 5.0 and 5.4×104/Kg, respectively. No adverse events have been recorded during mobilization or intrahepatic SCs re-infusion. Updated results on current patients and future patients will be presented at the Meeting. Disclosures: No relevant conflicts of interest to declare.

Compromised nutritional status in patients with end-stage liver disease: Role of gut microbiota

2018 ◽  
Vol 17 (4) ◽  
pp. 290-300 ◽  
Author(s):  
Maria Vasco ◽  
Rossella Paolillo ◽  
Concetta Schiano ◽  
Linda Sommese ◽  
Oreste Cuomo ◽  
...  
Keyword(s):  
Liver Disease ◽  
Nutritional Status ◽  
Gut Microbiota ◽  
End Stage Liver Disease ◽  
End Stage
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