Evaluation of Arteriovenous Shunting in Patients With End-Stage Liver Disease: Potential Role of Early Right Heart Catheterization

2015 ◽  
Vol 47 (10) ◽  
pp. 2892-2896
Author(s):  
M. Nagiub ◽  
R.T. Stravitz ◽  
D. Grinnan ◽  
W. Moskowitz
Keyword(s):  
Liver Disease ◽  
Potential Role ◽  
Right Heart Catheterization ◽  
Heart Catheterization ◽  
Right Heart ◽  
Arteriovenous Shunting ◽  
End Stage Liver Disease ◽  
End Stage

scholarly journals Performance of the model for end-stage liver disease score for mortality prediction and the potential role of etiology

2021 ◽  
Author(s):  
Gennaro D’Amico ◽  
Luigi Maruzzelli ◽  
Aldo Airoldi ◽  
Ioannis Petridis ◽  
Giulia Tosetti ◽  
...  
Keyword(s):  
Liver Disease ◽  
Potential Role ◽  
Mortality Prediction ◽  
Disease Score ◽  
End Stage Liver Disease ◽  
End Stage

The role of the sphingolipid pathway in liver fibrosis: an emerging new potential target for novel therapies

2020 ◽  
Vol 318 (6) ◽  
pp. C1055-C1064 ◽  
Author(s):  
Yuval Ishay ◽  
Dean Nachman ◽  
Tawfik Khoury ◽  
Yaron Ilan
Keyword(s):  
Liver Disease ◽  
Potential Role ◽  
Cellular Membrane ◽  
Biological Functions ◽  
Bioactive Lipids ◽  
Potential Therapeutic Target ◽  
End Stage Liver Disease ◽  
Sphingosine 1 Phosphate ◽  
End Stage

Sphingolipids (SL) are a family of bioactive lipids and a major cellular membrane structural component. SLs include three main compounds: ceramide (Cer), sphingosine (Sp), and sphingosine-1-phosphate (S-1P), all of which have emerging roles in biological functions in cells, especially in the liver. They are under investigation in various liver diseases, including cirrhosis and end-stage liver disease. In this review, we provide an overview on the role of SLs in liver pathobiology and focus on their potential role in the development of hepatic fibrosis. We describe recent evidence and suggest SLs are a promising potential therapeutic target for the treatment of liver disease and fibrosis.

A Potential Role of Sex Hormones in the Progression of end Stage Liver Disease

2016 ◽  
Vol 64 (2) ◽  
pp. S281-S282
Author(s):  
P. Udompap ◽  
A. Mannalithara ◽  
D. Kim ◽  
W.R. Kim
Keyword(s):  
Liver Disease ◽  
Sex Hormones ◽  
Potential Role ◽  
End Stage Liver Disease ◽  
End Stage

Glomerular injury in end-stage liver disease — role of circulating IgG and IgM immune complexes

1993 ◽  
Vol 7 (1) ◽  
pp. 6-10 ◽  
Author(s):  
Lawrence S. Milner ◽  
Mark T. Houser ◽  
Peter C. Kolbeck ◽  
Dean L. Antonson ◽  
Thomas L. McDonald ◽  
...  
Keyword(s):  
Liver Disease ◽  
Immune Complexes ◽  
Glomerular Injury ◽  
End Stage Liver Disease ◽  
End Stage

The Role of Model of End-Stage Liver Disease Score in Predicting Outcomes of Carotid Endarterectomy in Patients with Liver Disease

2015 ◽  
Vol 221 (4) ◽  
pp. S185-S186
Author(s):  
Brianna M. Krafcik ◽  
Denis Rybin ◽  
Gheorghe Doros ◽  
Mohammed H. Eslami ◽  
Alik Farber ◽  
...  
Keyword(s):  
Liver Disease ◽  
Carotid Endarterectomy ◽  
Disease Score ◽  
End Stage Liver Disease ◽  
End Stage

scholarly journals The role of Model for End-Stage Liver Disease (MELD) score in predicting outcomes for lower extremity bypass

2016 ◽  
Vol 64 (1) ◽  
pp. 124-130 ◽  
Author(s):  
Brianna M. Krafcik ◽  
Alik Farber ◽  
Mohammad H. Eslami ◽  
Jeffrey A. Kalish ◽  
Denis Rybin ◽  
...  
Keyword(s):  
Liver Disease ◽  
Lower Extremity ◽  
Meld Score ◽  
End Stage Liver Disease ◽  
End Stage

Coronary sinus oxidative stress markers allow for accurate assessment of the prognosis in patients with advanced heart failure awaiting transplantation

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
W Szczurek ◽  
M Gasior ◽  
M Skrzypek ◽  
K Antonczyk ◽  
A Bielka ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Right Heart Catheterization ◽  
Heart Catheterization ◽  
Funding Source ◽  
Right Heart ◽  
Stress Markers ◽  
End Stage ◽  
Medical University ◽  
Prognostic Power

Abstract Background Oxidative stress is a cause of cardiac diseases and contribute to apoptosis, cardiac remodeling, cardiac growth and repair. The end-stage heart failure (HF) is associated with ischemia-reperfusion, increased neurohumoral activity, cytokine stimulation and presence of inflammatory cells. Above factors are stimuli which generate free radicals and can induce oxidative stress in the heart and cause damage to essential myocardial structures and function. However, the role of oxidative stress in end-stage HF has not been fully understood. Purpose This study aimed to evaluate the prognostic value of the oxidative stress markers in ambulatory patients with end-stage HF awaiting heart transplantation (HT) during a 1.5 year follow-up period. Method The study was a prospective analysis of 85 optimally treated adult patients with end-stage HF, who were added to the HT waiting list at the Cardiology Department between 2015 and 2016. At the time of enrollment to the study routine laboratory tests, cardiopulmonary exercise test, echocardiography, spirometry and right heart catheterization were performed in all patients. During right heart catheterization, 10 ml of coronary sinus blood was additionally collected to determine total oxidant status (TOS) and total antioxidant capacity (TAC) levels. TOS and TAC were measured by Erel's method. The endpoint was all-cause mortality during a 1.5 years follow-up. The Medical University of Silesia's local Institutional Review Board approved the study protocol, and all patients provided informed consent. Results Median age of the patients was 53.0 (43.0–56.0) years and 90.6% of them were male. During the observation period, the mortality rate was 40%. The area under the receiver operating characteristics (ROC) curves indicated an acceptable discriminatory power of TAC (AUC: 0.780 [CI: 0.677–0.883]; sensitivity 56%, and specificity 90%); and excellent power of TOS (AUC: 0.9530 [CI: 0.9279–0.9781]; sensitivity 88%, and specificity 94%) for 1.5 years mortality. Patients with a low TAC level (≤1.10) had a significantly worse 1.5-year survival compared to the group with a high TAC level (>1.10) (1.5 year survival: 20.8% versus 75.4%; (long rank p<0.001). Similarly, patients with a high TOS level (≥3.11) had a significantly worse survival compared to the group with a low TOS level (<3.11) (1.5- year survival: 9.1% versus 92.3%; p<0.001). Conclusion TAC with acceptable prognostic power and TOS with excellent prognostic power allows assessment of the prognosis in end-stage HF during a 1.5 year follow-up period. Funding Acknowledgement Type of funding source: Public Institution(s). Main funding source(s): Medical University of Silesia, Katowice, Poland

THE ROLE OF INHALED NITRIC OXIDE IN END-STAGE LIVER DISEASE

1998 ◽  
Vol 89 (Supplement) ◽  
pp. 420A
Author(s):  
M A E Ramsay ◽  
K Lynch ◽  
H A T Hein ◽  
K Ramsay ◽  
R I Simpson ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Liver Disease ◽  
Inhaled Nitric Oxide ◽  
End Stage Liver Disease ◽  
End Stage
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