Proton pump inhibitor use and risk of hip fractures among community-dwelling persons with Alzheimer's disease-a nested case-control study

2018 ◽  
Vol 47 (8) ◽  
pp. 1135-1142 ◽  
Author(s):  
S. Torvinen-Kiiskinen ◽  
A.-M. Tolppanen ◽  
M. Koponen ◽  
A. Tanskanen ◽  
J. Tiihonen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Hip Fractures ◽  
Case Control Study ◽  
Case Control ◽  
Community Dwelling ◽  
Nested Case Control ◽  
Control Study

scholarly journals Metformin and Risk of Alzheimer’s Disease Among Community-Dwelling People With Diabetes: A National Case-Control Study

2019 ◽  
Vol 105 (4) ◽  
pp. e963-e972 ◽  
Author(s):  
Janet K Sluggett ◽  
Marjaana Koponen ◽  
J Simon Bell ◽  
Heidi Taipale ◽  
Antti Tanskanen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Case Control ◽  
Community Dwelling ◽  
High Dose ◽  
Defined Daily Doses ◽  
Increased Risk ◽  
Control Study

Abstract Context Type 2 diabetes has been linked with an increased risk of Alzheimer’s disease (AD). Studies on the association between metformin use and AD have reported conflicting results. Objective To investigate whether metformin use modifies the association between diabetes and incident, clinically verified AD. Design Nested case-control study. Setting All community-dwelling people in Finland. Participants Cases were all community-dwelling Finns with AD diagnosed from 2005 to 2011 and with diabetes diagnosed ≥ 3 years before AD (n = 9862). Cases were matched with up to 2 control persons by age, sex, and diabetes duration (n = 19 550). Main outcome measure Cumulative metformin exposure was determined from reimbursed dispensings over a 10- to 16-year period. Adjusted odds ratios (aORs) were calculated using conditional logistic regression to estimate associations, with adjustment for potential confounders. Results A total of 7225 (73.3%) cases and 14528 (74.3%) controls received metformin at least once. Metformin use (ever use) was not associated with incident AD (aOR 0.99; 95% confidence interval [CI], 0.94–1.05). The adjusted odds of AD were lower among people dispensed metformin for ≥ 10 years (aOR 0.85; 95% CI, 0.76–0.95), those dispensed cumulative defined daily doses (DDDs) of < 1825–3650 (aOR 0.91; 95% CI, 0.84–0.98) and > 3650 DDDs (aOR 0.77; 95% CI, 0.67–0.88), and among persons dispensed an average of 2 g metformin daily (aOR 0.89; 95% CI, 0.82–0.96). Conclusion In this large national sample we found no evidence that metformin use increases the risk of AD. Conversely, long-term and high-dose metformin use was associated with a lower risk of incident AD in older people with diabetes.

scholarly journals Association between Tooth Loss and Alzheimer’s Disease in a Nested Case–Control Study Based on a National Health Screening Cohort

2021 ◽  
Vol 10 (17) ◽  
pp. 3763
Author(s):  
Ji Hee Kim ◽  
Jae Keun Oh ◽  
Jee Hye Wee ◽  
Yoo Hwan Kim ◽  
Soo-Hwan Byun ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
National Health ◽  
Tooth Loss ◽  
Case Control Study ◽  
Case Control ◽  
Health Screening ◽  
Missing Teeth ◽  
Nested Case Control ◽  
Control Study

Background: Reports on the possible risks for Alzheimer’s disease (AD) have included tooth loss as a potential risk factor. However, there are few studies addressing the association between tooth loss and AD in a large sample of participants. Accordingly, the objective of the current study was to explore the association of tooth loss with the development of AD in Korean adults. Methods: This nested case–control study, which is an analysis utilizing the data of the Korean National Health Insurance Service Health Screening Cohort study, randomly selected AD and control participants among Korean residents aged ≥60 years. The association between the number of missing teeth and AD occurrence was examined using a logistic regression model. Participants’ lifestyle factors (smoking and alcohol consumption) and various medical conditions and comorbidities were included as covariates. Results: The mean number of missing teeth was 2.94 in the AD group and 2.59 in the control group. After adjusting for covariates, tooth loss was significantly associated with AD, with an odds ratio (OR) (per 16 missing teeth) of 1.15 (95% confidence interval (CI) = 1.07–1.23, p < 0.001). Conclusions: Tooth loss remained consistently significantly associated with an increased risk of AD for both upper and lower tooth loss. A higher number of missing teeth was related to a higher probability of AD occurrence in an elderly Korean population. Efforts to manage tooth loss could be a possible approach to prevent AD.

The risk of Alzheimer's disease associated with benzodiazepines and related drugs: a nested case-control study

2018 ◽  
Vol 138 (2) ◽  
pp. 91-100 ◽  
Author(s):  
V. Tapiainen ◽  
H. Taipale ◽  
A. Tanskanen ◽  
J. Tiihonen ◽  
S. Hartikainen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

P4-236: Comorbidity in Alzheimer's Disease: A Nested Case-Control Study

2016 ◽  
Vol 12 ◽  
pp. P1120-P1120
Author(s):  
Jin-Yi Hsu ◽  
Jen-Hung Wang ◽  
Ya-Ju Wu ◽  
Raymond Y. Lo
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

Risk of Death Among Persons with Alzheimer's Disease: A National Register-Based Nested Case-Control Study

2012 ◽  
Vol 33 (1) ◽  
pp. 157-164 ◽  
Author(s):  
Eija Lönnroos ◽  
Pentti Kyyrönen ◽  
J. Simon Bell ◽  
Tischa J.M. van der Cammen ◽  
Sirpa Hartikainen
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Case Control Study ◽  
Case Control ◽  
National Register ◽  
Risk Of Death ◽  
Nested Case Control ◽  
Control Study

Proton-pump inhibitor use and hip fractures in men: a population-based case-control study

2014 ◽  
Vol 24 (4) ◽  
pp. 286-290 ◽  
Author(s):  
Annette L. Adams ◽  
Mary Helen Black ◽  
Jian L. Zhang ◽  
Jiaxiao M. Shi ◽  
Steven J. Jacobsen
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Hip Fractures ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Control Study
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