scholarly journals Antiviral treatment associated with reduced risk of clinical Alzheimer's disease—A nested case‐control study

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Eva‐Stina Hemmingsson ◽  
Ellen Hjelmare ◽  
Bodil Weidung ◽  
Jan Olsson ◽  
Maria Josefsson ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Case Control Study ◽  
Antiviral Treatment ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study ◽  
Reduced Risk

scholarly journals Association between Tooth Loss and Alzheimer’s Disease in a Nested Case–Control Study Based on a National Health Screening Cohort

2021 ◽  
Vol 10 (17) ◽  
pp. 3763
Author(s):  
Ji Hee Kim ◽  
Jae Keun Oh ◽  
Jee Hye Wee ◽  
Yoo Hwan Kim ◽  
Soo-Hwan Byun ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
National Health ◽  
Tooth Loss ◽  
Case Control Study ◽  
Case Control ◽  
Health Screening ◽  
Missing Teeth ◽  
Nested Case Control ◽  
Control Study

Background: Reports on the possible risks for Alzheimer’s disease (AD) have included tooth loss as a potential risk factor. However, there are few studies addressing the association between tooth loss and AD in a large sample of participants. Accordingly, the objective of the current study was to explore the association of tooth loss with the development of AD in Korean adults. Methods: This nested case–control study, which is an analysis utilizing the data of the Korean National Health Insurance Service Health Screening Cohort study, randomly selected AD and control participants among Korean residents aged ≥60 years. The association between the number of missing teeth and AD occurrence was examined using a logistic regression model. Participants’ lifestyle factors (smoking and alcohol consumption) and various medical conditions and comorbidities were included as covariates. Results: The mean number of missing teeth was 2.94 in the AD group and 2.59 in the control group. After adjusting for covariates, tooth loss was significantly associated with AD, with an odds ratio (OR) (per 16 missing teeth) of 1.15 (95% confidence interval (CI) = 1.07–1.23, p < 0.001). Conclusions: Tooth loss remained consistently significantly associated with an increased risk of AD for both upper and lower tooth loss. A higher number of missing teeth was related to a higher probability of AD occurrence in an elderly Korean population. Efforts to manage tooth loss could be a possible approach to prevent AD.

The risk of Alzheimer's disease associated with benzodiazepines and related drugs: a nested case-control study

2018 ◽  
Vol 138 (2) ◽  
pp. 91-100 ◽  
Author(s):  
V. Tapiainen ◽  
H. Taipale ◽  
A. Tanskanen ◽  
J. Tiihonen ◽  
S. Hartikainen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

P4-236: Comorbidity in Alzheimer's Disease: A Nested Case-Control Study

2016 ◽  
Vol 12 ◽  
pp. P1120-P1120
Author(s):  
Jin-Yi Hsu ◽  
Jen-Hung Wang ◽  
Ya-Ju Wu ◽  
Raymond Y. Lo
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

Risk of Death Among Persons with Alzheimer's Disease: A National Register-Based Nested Case-Control Study

2012 ◽  
Vol 33 (1) ◽  
pp. 157-164 ◽  
Author(s):  
Eija Lönnroos ◽  
Pentti Kyyrönen ◽  
J. Simon Bell ◽  
Tischa J.M. van der Cammen ◽  
Sirpa Hartikainen
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Case Control Study ◽  
Case Control ◽  
National Register ◽  
Risk Of Death ◽  
Nested Case Control ◽  
Control Study

Medical Comorbidity in Alzheimer’s Disease: A Nested Case-Control Study

2018 ◽  
Vol 63 (2) ◽  
pp. 773-781 ◽  
Author(s):  
Jen-Hung Wang ◽  
Ya-Ju Wu ◽  
Boon Lead Tee ◽  
Raymond Y. Lo
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Case Control Study ◽  
Case Control ◽  
Medical Comorbidity ◽  
Nested Case Control ◽  
Control Study

Herpes simplex infection and the risk of Alzheimer's disease: A nested case-control study

2015 ◽  
Vol 11 (6) ◽  
pp. 587-592 ◽  
Author(s):  
Hugo Lövheim ◽  
Jonathan Gilthorpe ◽  
Anders Johansson ◽  
Sture Eriksson ◽  
Göran Hallmans ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Herpes Simplex ◽  
Case Control Study ◽  
Case Control ◽  
Herpes Simplex Infection ◽  
Simplex Infection ◽  
Nested Case Control ◽  
Control Study

Anticholinergic Exposure and Risk of Pneumonia in Persons with Alzheimer’s Disease: A Nested Case-Control Study

2017 ◽  
Vol 56 (1) ◽  
pp. 119-128 ◽  
Author(s):  
Pasi Lampela ◽  
Anna-Maija Tolppanen ◽  
Antti Tanskanen ◽  
Jari Tiihonen ◽  
Sirpa Hartikainen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

scholarly journals Metformin Use and Subsequent Alzheimer’s Disease Incidence in Patients With Newly Diagnosed Type 2 Diabetes: a Population-based Nested Case-control Study

2021 ◽  
Author(s):  
Junghee Ha ◽  
Dong Woo Choi ◽  
Kwang Joon Kim ◽  
So Yeon Cho ◽  
Hyunjeong Kim ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Alzheimer’S Disease ◽  
Type 2 Diabetes ◽  
Alzheimer's Disease ◽  
Case Control Study ◽  
Case Control ◽  
Newly Diagnosed ◽  
Nested Case Control ◽  
Control Study

Abstract Background: Metformin reduces insulin resistance, which may be shared pathophysiology between diabetes mellitus (DM) and Alzheimer’s disease (AD). Thus, it has been hypothesized that metformin may be effective against AD; however, evidence of metformin effects on AD development remains insufficient and conflicting. We investigated Alzheimer’s disease risk in patients with newly diagnosed type 2 diabetes mellitus treated with metformin.Methods: This retrospective, observational, nested case-control study included enrolled patients with newly diagnosed type 2 diabetes mellitus in the Korean National Health Insurance Service diabetes mellitus cohort (2002–2017). Among 70,499 DM patients who were dementia-free at the time of DM diagnosis, 1,675 AD cases identified were matched to 8,375 controls by age, sex, and DM onset and duration. Association of AD with metformin use were analyzed using multivariable conditional logistic regression analyses adjusted for comorbidities and cardiometabolic risk profile. Results: Metformin use was associated with an increased adjusted odds ratio (AOR) of AD (1.50; 95% CI, 1.23–1.83). The strength of the association increased with the cumulative daily defined dose per day in metformin users. The risk was more pronounced among patients with a longer duration of DM (1.48; 95% CI, 1.14 to 1.91, for a DM duration of 5–9 years; 2.18; 95% CI, 1.41 to 3.39 for a duration greater than 10 years), while no statistical significance was found in the patients with DM duration less than 5 years (AOR 0.88; 95%CI 0.54–1.43). Furthermore, the risk of AD was significantly higher in DM patients with depression (AOR 2.05; 1.02–4.12). Conclusions: Given the huge number of patients with DM who are taking metformin worldwide, a double-blinded, prospective study is required to determine the long-term cognitive safety of metformin.

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