scholarly journals Letter: mucosal healing is associated with improved long-term outcomes in Crohn's disease - authors' reply

2016 ◽  
Vol 43 (12) ◽  
pp. 1347-1348
Author(s):  
S. C. Shah ◽  
J.-F. Colombel ◽  
B. E. Sands ◽  
N. Narula
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Mucosal Healing ◽  
Long Term Outcomes

scholarly journals P628 Long-term outcomes with transmural healing vs. mucosal healing in Crohn’s disease: time for new treatment goals ?

2019 ◽  
Vol 13 (Supplement_1) ◽  
pp. S431-S432
Author(s):  
F Castiglione ◽  
N Imperatore ◽  
A Testa ◽  
G D De Palma ◽  
O M Nardone ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Mucosal Healing ◽  
Treatment Goals ◽  
Long Term Outcomes ◽  
New Treatment

OC.09.2 LONG-TERM OUTCOMES WITH TRANSMURAL HEALING VERSUS MUCOSAL HEALING IN CROHN'S DISEASE: TIME FOR NEW TREATMENT GOALS?

2019 ◽  
Vol 51 ◽  
pp. e100-e101
Author(s):  
F. Castiglione ◽  
N. Imperatore ◽  
A. Testa ◽  
G.D. De Palma ◽  
O.M. Nardone ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Mucosal Healing ◽  
Treatment Goals ◽  
Long Term Outcomes ◽  
New Treatment

scholarly journals Comparison of transmural healing and mucosal healing as predictors of positive long-term outcomes in Crohn’s disease

2021 ◽  
Vol 14 ◽  
pp. 175628482110162
Author(s):  
Li Ma ◽  
Wenbo Li ◽  
Nan Zhuang ◽  
Hong Yang ◽  
Wei Liu ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Clinical Significance ◽  
Independent Predictor ◽  
Mucosal Healing ◽  
Potential Treatment ◽  
Plain Language ◽  
Long Term Outcomes ◽  
Treatment Endpoint

Background: Transmural healing (TH) is being increasingly recognized for reflecting deep remission in Crohn’s disease (CD). The long-term clinical significance of achieving TH is still not fully known. We aimed to evaluate TH as a predictor of long-term positive outcomes using intestinal ultrasonography (US), with comparison with the established endpoint mucosal healing (MH). Methods: CD patients were consecutively recruited from September 2015 to August 2018 at a single tertiary hospital. All patients were evaluated at baseline and followed up at 6 months prospectively with a guideline-based treatment regimen. Achieving TH/MH or not was evaluated by US/colonoscopy at the first follow-up. Long-term outcomes including steroid-free clinical remission (CR), drug escalation, hospitalization, and surgery, were recorded after at least another 12 months. Results: We identified 77 patients with a median age of 30 years (range, 12–73 years). Twenty-five (32%) patients achieved TH, and 31 (40%) patients achieved MH. TH and MH were poorly correlated (Cohen’s κ = 0.387; p < 0.05). Univariate analysis showed that both MH and TH were associated with better long-term outcomes. In multivariate analysis, TH was an independent predictor of steroid-free CR [odds ratio (OR), 52.6; p <  0.001], drug escalation (OR, 0.1; p =  0.002), and hospitalization (OR, 0.05; p =  0.005), while MH was an independent predictor of drug escalation (OR, 0.3; p =  0.05). Smoking habit was the only predictor of surgery (OR, 6.6; p =  0.02). Conclusion: TH is an independent predictor of more favorable long-term outcomes than MH, suggesting that TH could become the potential treatment endpoint in CD. Plain language summary Transmural healing predicts good prognosis in Crohn’s disease The therapeutic endpoints of Crohn’s disease keep evolving. The long-term clinical significance of achieving transmural healing is not fully discovered. Transmural healing is an independent predictor of more favorable long-term outcomes than mucosal healing. Transmural healing could become the potential treatment endpoint in Crohn’s disease.

Long-Term Outcomes of Infliximab Treatment in 582 Korean Patients with Crohn’s Disease: A Hospital-Based Cohort Study

2016 ◽  
Vol 61 (7) ◽  
pp. 2060-2067 ◽  
Author(s):  
Sang Hyoung Park ◽  
Sung Wook Hwang ◽  
Min Seob Kwak ◽  
Wan Soo Kim ◽  
Jeong-Mi Lee ◽  
...  
Keyword(s):  
Cohort Study ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Infliximab Treatment ◽  
Long Term Outcomes ◽  
Korean Patients

scholarly journals P173 Predictors of long-term outcomes of perianal fistulizing Crohn's disease

2013 ◽  
Vol 7 ◽  
pp. S78
Author(s):  
B. Tchoundjeu ◽  
T. Rohou ◽  
G. Bouguen ◽  
D. Cuen ◽  
T. Wallenhorst ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Long Term Outcomes

scholarly journals Long‐term outcomes of perianal fistulizing Crohn's disease in the biologic era

JGH Open ◽  
2020 ◽  
Author(s):  
Tanya Lee ◽  
Michael A Kamm ◽  
Sally Bell ◽  
Mark Lust ◽  
Steve Brown ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Long Term Outcomes
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