Dynamic expression of molecules that control limb muscle development includingFhl1in hind limbs of different gestational age

Apmis ◽  
2014 ◽  
Vol 122 (9) ◽  
pp. 766-771 ◽  
Author(s):  
Wang Li-Li ◽  
Peng Zhao-Hong ◽  
Fan Yang ◽  
Li Lian-Yong ◽  
Wu Di ◽  
...  
Keyword(s):  
Gestational Age ◽  
Muscle Development ◽  
Limb Muscle ◽  
Hind Limbs ◽  
Dynamic Expression ◽  
Control Limb

Sonic hedgehog is a survival factor for hypaxial muscles during mouse development

Development ◽  
2001 ◽  
Vol 128 (5) ◽  
pp. 743-752 ◽  
Author(s):  
M. Kruger ◽  
D. Mennerich ◽  
S. Fees ◽  
R. Schafer ◽  
S. Mundlos ◽  
...  
Keyword(s):  
Sonic Hedgehog ◽  
Muscle Development ◽  
Mouse Strains ◽  
Limb Muscle ◽  
Mouse Development ◽  
Vertebrate Embryos ◽  
Epaxial Muscles ◽  
Inactivating Mutations ◽  
Myogenic Precursor ◽  
Hypaxial Muscle

Sonic hedgehog (Shh) has been proposed to function as an inductive and trophic signal that controls development of epaxial musculature in vertebrate embryos. In contrast, development of hypaxial muscles was assumed to occur independently of Shh. We here show that formation of limb muscles was severely affected in two different mouse strains with inactivating mutations of the Shh gene. The limb muscle defect became apparent relatively late and initial stages of hypaxial muscle development were unaffected or only slightly delayed. Micromass cultures and cultures of tissue fragments derived from limbs under different conditions with or without the overlaying ectoderm indicated that Shh is required for the maintenance of the expression of myogenic regulatory factors (MRFs) and, consecutively, for the formation of differentiated limb muscle myotubes. We propose that Shh acts as a survival and proliferation factor for myogenic precursor cells during hypaxial muscle development. Detection of a reduced but significant level of Myf5 expression in the epaxial compartment of somites of Shh homozygous mutant embryos at E9.5 indicated that Shh might be dispensable for the initiation of myogenesis both in hypaxial and epaxial muscles. Our data suggest that Shh acts similarly in both somitic compartments as a survival and proliferation factor and not as a primary inducer of myogenesis.

Mox2 is a component of the genetic hierarchy controlling limb muscle development

Nature ◽  
10.1038/21892 ◽  
1999 ◽  
Vol 400 (6739) ◽  
pp. 69-73 ◽  
Author(s):  
Baljinder S. Mankoo ◽  
Nina S. Collins ◽  
Peter Ashby ◽  
Elena Grigorieva ◽  
Larysa H. Pevny ◽  
...  
Keyword(s):  
Muscle Development ◽  
Limb Muscle ◽  
Genetic Hierarchy

scholarly journals Transient expression of collagen type XIV during muscle development and its reappearance after denervation and degeneration.

1996 ◽  
Vol 44 (8) ◽  
pp. 907-918 ◽  
Author(s):  
S Tono-Oka ◽  
S Tanase ◽  
T Miike ◽  
H Tanaka
Keyword(s):  
Muscle Activity ◽  
Muscle Development ◽  
Collagen Type ◽  
Embryonic Chick ◽  
Dorsal Region ◽  
Connective Tissues ◽  
Collagen Mrna ◽  
Collagen Expression ◽  
Hind Limbs

In the formation of muscle pattern, the architectural arrangement is believed to be controlled by the local connective tissue cells. In this study we examined the immunohistological localization of Type XIV collagen recognized by a monoclonal antibody, MAb DBM, in embryonic chick hind limbs from stage (St.) 27 to 2 weeks post hatching. DBM staining was transiently observed in the epimysium from St. 30, in the perimysium of the dorsal region from St. 37, and in the entire perimysium from St. 39. After hatching, DBM staining was notably diminished in both epimysium and perimysium. In contrast, DBM staining and in situ hybridization signals for Type XIV collagen mRNA increased in the muscle connective tissues after denervation and around the regenerating muscle fibers. Therefore, Type XIV collagen expression appears to coincide with muscle activity and muscle regenerating conditions, and Type XIV collagen is considered to play roles in muscle development and regeneration.

Axial and limb muscle development: dialogue with the neighbourhood

2016 ◽  
Vol 73 (23) ◽  
pp. 4415-4431 ◽  
Author(s):  
Marianne Deries ◽  
Sólveig Thorsteinsdóttir
Keyword(s):  
Muscle Development ◽  
Limb Muscle
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