scholarly journals Divergent functions of murine Pax3 and Pax7 in limb muscle development

2004 ◽  
Vol 18 (9) ◽  
pp. 1088-1105 ◽  
Author(s):  
F. Relaix
Keyword(s):  
Muscle Development ◽  
Limb Muscle

Sonic hedgehog is a survival factor for hypaxial muscles during mouse development

Development ◽  
2001 ◽  
Vol 128 (5) ◽  
pp. 743-752 ◽  
Author(s):  
M. Kruger ◽  
D. Mennerich ◽  
S. Fees ◽  
R. Schafer ◽  
S. Mundlos ◽  
...  
Keyword(s):  
Sonic Hedgehog ◽  
Muscle Development ◽  
Mouse Strains ◽  
Limb Muscle ◽  
Mouse Development ◽  
Vertebrate Embryos ◽  
Epaxial Muscles ◽  
Inactivating Mutations ◽  
Myogenic Precursor ◽  
Hypaxial Muscle

Sonic hedgehog (Shh) has been proposed to function as an inductive and trophic signal that controls development of epaxial musculature in vertebrate embryos. In contrast, development of hypaxial muscles was assumed to occur independently of Shh. We here show that formation of limb muscles was severely affected in two different mouse strains with inactivating mutations of the Shh gene. The limb muscle defect became apparent relatively late and initial stages of hypaxial muscle development were unaffected or only slightly delayed. Micromass cultures and cultures of tissue fragments derived from limbs under different conditions with or without the overlaying ectoderm indicated that Shh is required for the maintenance of the expression of myogenic regulatory factors (MRFs) and, consecutively, for the formation of differentiated limb muscle myotubes. We propose that Shh acts as a survival and proliferation factor for myogenic precursor cells during hypaxial muscle development. Detection of a reduced but significant level of Myf5 expression in the epaxial compartment of somites of Shh homozygous mutant embryos at E9.5 indicated that Shh might be dispensable for the initiation of myogenesis both in hypaxial and epaxial muscles. Our data suggest that Shh acts similarly in both somitic compartments as a survival and proliferation factor and not as a primary inducer of myogenesis.

Dynamic expression of molecules that control limb muscle development includingFhl1in hind limbs of different gestational age

Apmis ◽  
2014 ◽  
Vol 122 (9) ◽  
pp. 766-771 ◽  
Author(s):  
Wang Li-Li ◽  
Peng Zhao-Hong ◽  
Fan Yang ◽  
Li Lian-Yong ◽  
Wu Di ◽  
...  
Keyword(s):  
Gestational Age ◽  
Muscle Development ◽  
Limb Muscle ◽  
Hind Limbs ◽  
Dynamic Expression ◽  
Control Limb

Mox2 is a component of the genetic hierarchy controlling limb muscle development

Nature ◽  
10.1038/21892 ◽  
1999 ◽  
Vol 400 (6739) ◽  
pp. 69-73 ◽  
Author(s):  
Baljinder S. Mankoo ◽  
Nina S. Collins ◽  
Peter Ashby ◽  
Elena Grigorieva ◽  
Larysa H. Pevny ◽  
...  
Keyword(s):  
Muscle Development ◽  
Limb Muscle ◽  
Genetic Hierarchy

Axial and limb muscle development: dialogue with the neighbourhood

2016 ◽  
Vol 73 (23) ◽  
pp. 4415-4431 ◽  
Author(s):  
Marianne Deries ◽  
Sólveig Thorsteinsdóttir
Keyword(s):  
Muscle Development ◽  
Limb Muscle

Variation in protein abundance profiles in the M. semitendinosus of lambs bred from sires selected on the basis of growth and muscling potential

2006 ◽  
Vol 57 (6) ◽  
pp. 671 ◽  
Author(s):  
M. B. McDonagh ◽  
K. L. Ferguson ◽  
A. Bacic ◽  
G. E. Gardner ◽  
R. S. Hegarty
Keyword(s):  
Growth Rate ◽  
Energy Metabolism ◽  
Hind Limb ◽  
Muscle Development ◽  
High Growth ◽  
Apparent Difference ◽  
Limb Muscle ◽  
Cellular Mechanisms ◽  
Semitendinosus Muscle ◽  
Hind Limb Muscle

Relative abundance of proteins localised in the nuclear-enriched, total cell membrane and cytosolic fractions of the semitendinosus muscle was compared between lambs bred from control (C), high muscling (M), and high growth rate (G) sires. In total, 31 proteins were identified whose abundance was differentially regulated between sire type. Differences in hind-limb muscle development between M lambs and C and G lambs were reflected in levels of proteins that regulate or function in cellular mechanisms of protein and energy metabolism. Despite no apparent difference in hind-limb muscle growth in G lambs compared to C, G lambs exhibited marked differences in proteins involved in regulation and function of energy metabolism. These results detail pathways that can be specifically targeted to enhance muscle accretion and growth in lambs. The development of means to manipulate these cellular mechanisms may yield greater gains in muscle accretion and growth rate than breeding on the basis for genetic capacity alone.

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