Enteroantigen (eAg)-binding B lymphocytes in the mouse - phenotype, distribution, function and eAg-specific antibody secretion

Apmis ◽  
2013 ◽  
Vol 122 (7) ◽  
pp. 616-627 ◽  
Author(s):  
Freja Albjerg Venning ◽  
Mette Louise Trempenau ◽  
Esben Schmidt ◽  
Mogens Helweg Claesson
Keyword(s):  
Distribution Function ◽  
B Lymphocytes ◽  
Specific Antibody ◽  
Mouse Phenotype ◽  
Phenotype Distribution ◽  
Antibody Secretion

scholarly journals Polyclonal activation of human B lymphocytes by Fc fragments. I. Characterization of the cellular requirements for Fc fragment-mediated polyclonal antibody secretion by human peripheral blood B lymphocytes.

1981 ◽  
Vol 154 (3) ◽  
pp. 778-790 ◽  
Author(s):  
E L Morgan ◽  
W O Weigle
Keyword(s):  
T Cells ◽  
B Lymphocytes ◽  
Polyclonal Antibody ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Cell Lineage ◽  
Fc Fragment ◽  
Antibody Secretion

Fc fragments derived from human immunoglobulin were found to be capable of inducing both a proliferative and polyclonal antibody response in human peripheral blood lymphocyte cultures. The cell population proliferating in response to Fc fragments belongs to the B cell lineage. Expression of polyclonal antibody formation requires the presence of both adherent monocytes and T cells. The role of the monocyte is to enzymatically cleave the Fc fragment into 19,000 mol wt Fc subfragments that are then able to induce polyclonal antibody secretion. Stimulation of polyclonal antibody production by Fc subfragments occurs in the absence of adherent monocytes but still requires the presence of T cells.

scholarly journals B-lymphocyte reconstitution after repeated rituximab treatment in a child with steroid-dependent autoimmune hemolytic anemia

2011 ◽  
Vol 3 (4) ◽  
pp. 28 ◽  
Author(s):  
Annelieke A.A. Van der Linde ◽  
Ellen J.H. Schatorjé ◽  
Annemieke M. Van der Weij ◽  
Eugenie F.A. Gemen ◽  
Esther De Vries
Keyword(s):  
B Lymphocytes ◽  
Hemolytic Anemia ◽  
Antibody Production ◽  
Specific Antibody ◽  
Autoimmune Hemolytic Anemia ◽  
B Lymphocyte ◽  
Lymphocyte Subpopulations ◽  
Steroid Dependent ◽  
Specific Antibody Production

We report the detailed long-term reconstitution of B-lymphocyte subpopulations, immunoglobulins, and specific antibody production after two courses of rituximab in a young, previously healthy girl with steroid-dependent autoimmune hemolytic anemia. B-lymphocyte subpopulations were surprisingly normal directly after reconstitution. However, there was a slower reconstitution after the second rituximab course, especially of non-switched and switched memory B-lymphocytes, and a temporary decline in IgM below age-matched reference values.

scholarly journals ACTIVATION OF T AND B LYMPHOCYTES IN VITRO

1974 ◽  
Vol 139 (1) ◽  
pp. 24-43 ◽  
Author(s):  
Dieter Armerding ◽  
David H. Katz
Keyword(s):  
B Lymphocytes ◽  
Specific Antibody ◽  
Cell Function ◽  
Sheep Erythrocyte ◽  
Biological Action ◽  
Antibody Responses ◽  
Secondary Antibody ◽  
Protein Conjugates ◽  
Adjuvant Effects

The present studies were undertaken to analyze the nature of the effect of bacterial lipopolysaccharide (LPS) on antibody production in vitro. We have done this by making comparative studies of the effects of LPS on in vitro primary and secondary antibody responses to soluble hapten-protein conjugates and to particulate and soluble sheep erythrocyte antigens. The results obtained demonstrate that the biological action of LPS in vitro may be predominantly manifested on the function of B lymphocytes or T lymphocytes depending on the conditions employed. In the absence of antigen, LPS appears to act primarily on B lymphocytes. In the presence of antigen, however, the data presented here show that LPS significantly influences specific helper T-cell function and it is this latter influence that is predominantly responsible for the adjuvant effects of LPS on antigen-specific antibody responses.

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