scholarly journals The absence of functional bassoon at cone photoreceptor ribbon synapses affects signal transmission at Off cone bipolar cell contacts in mouse retina

2020 ◽  
Author(s):  
Norbert Babai ◽  
Julia Wittgenstein ◽  
Kaspar Gierke ◽  
Johann Helmut Brandstätter ◽  
Andreas Feigenspan
Keyword(s):  
Bipolar Cell ◽  
Signal Transmission ◽  
Mouse Retina ◽  
Cone Photoreceptor ◽  
Cell Contacts ◽  
Ribbon Synapses

Signal transmission at invaginating cone photoreceptor synaptic contacts following deletion of the presynaptic cytomatrix protein Bassoon in mouse retina

2019 ◽  
Vol 226 (2) ◽  
pp. e13241 ◽  
Author(s):  
Norbert Babai ◽  
Kaspar Gierke ◽  
Tanja Müller ◽  
Hanna Regus‐Leidig ◽  
Johann H. Brandstätter ◽  
...  
Keyword(s):  
Signal Transmission ◽  
Mouse Retina ◽  
Cone Photoreceptor ◽  
Synaptic Contacts

scholarly journals A QTL on Chromosome 10 Modulates Cone Photoreceptor Number in the Mouse Retina

2011 ◽  
Vol 52 (6) ◽  
pp. 3228 ◽  
Author(s):  
Irene E. Whitney ◽  
Mary A. Raven ◽  
Lu Lu ◽  
Robert W. Williams ◽  
Benjamin E. Reese
Keyword(s):  
Mouse Retina ◽  
Cone Photoreceptor ◽  
Chromosome 10

OFF bipolar cell density varies by subtype, eccentricity, and along the dorsal ventral axis in the mouse retina

2020 ◽  
Author(s):  
Michael J. Camerino ◽  
Ian J. Engerbretson ◽  
Parker A. Fife ◽  
Nathan B. Reynolds ◽  
Mikel H. Berria ◽  
...  
Keyword(s):  
Cell Density ◽  
Bipolar Cell ◽  
Mouse Retina

Early steps in the assembly of photoreceptor ribbon synapses in the mouse retina: The involvement of precursor spheres

2009 ◽  
Vol 512 (6) ◽  
pp. 814-824 ◽  
Author(s):  
Hanna Regus-Leidig ◽  
Susanne tom Dieck ◽  
Dana Specht ◽  
Lars Meyer ◽  
Johann Helmut Brandstätter
Keyword(s):  
Mouse Retina ◽  
Ribbon Synapses

Active zone protein CAST is a component of conventional and ribbon synapses in mouse retina

2006 ◽  
Vol 495 (4) ◽  
pp. 480-496 ◽  
Author(s):  
Maki Deguchi-Tawarada ◽  
Eiji Inoue ◽  
Etsuko Takao-Rikitsu ◽  
Marie Inoue ◽  
Isao Kitajima ◽  
...  
Keyword(s):  
Active Zone ◽  
Mouse Retina ◽  
Ribbon Synapses

scholarly journals Local signals in mouse horizontal cell dendrites

2017 ◽  
Author(s):  
Camille A. Chapot ◽  
Christian Behrens ◽  
Luke E. Rogerson ◽  
Tom Baden ◽  
Sinziana Pop ◽  
...  
Keyword(s):  
Glutamate Release ◽  
Horizontal Cell ◽  
Horizontal Cells ◽  
Single Type ◽  
Mouse Retina ◽  
Gabaergic Interneuron ◽  
List Type ◽  
Cone Photoreceptor ◽  
Cone Photoreceptors ◽  
Temporal Properties

SummaryThe mouse retina contains a single type of horizontal cell, a GABAergic interneuron that samples from all cone photoreceptors within reach and modulates their glutamatergic output via parallel feedback mechanisms. Because horizontal cells form an electrically-coupled network, they have been implicated in global signal processing, such as large scale contrast enhancement. Recently, it has been proposed that horizontal cells can also act locally at the level of individual cone photoreceptors. To test this possibility physiologically, we used two-photon microscopy to record light stimulus-evoked Ca2+signals in cone axon terminals and horizontal cell dendrites as well as glutamate release in the outer plexiform layer. By selectively stimulating the two mouse cone opsins with green and UV light, we assessed whether signals from individual cones remain “isolated” within horizontal cell dendritic tips, or whether they spread across the dendritic arbour. Consistent with the mouse‘s opsin expression gradient, we found that the Ca2+signals recorded from dendrites of dorsal horizontal cells were dominated by M- and those of ventral horizontal cells by S-opsin activation. The signals measured in neighbouring horizontal cell dendritic tips varied markedly in their chromatic preference, arguing against global processing. Rather, our experimental data and results from biophysically realistic modelling support the idea that horizontal cells can process cone input locally, extending the “classical” view of horizontal cells function. Pharmacologically removing horizontal cells from the circuitry reduced the sensitivity of the cone signal to low frequencies, suggesting that local horizontal cell feedback shapes the temporal properties of cone output.HighlightsLight-evoked Ca2+signals in horizontal cell dendrites reflect opsin gradientChromatic preferences in neighbouring dendritic tips vary markedlyMouse horizontal cells process cone photoreceptor input locallyLocal horizontal cell feedback shapes the temporal properties of cone outputeTOC BlurbChapot et al. show that local light responses in mouse horizontal cell dendrites inherit properties, including chromatic preference, from the presynaptic cone photoreceptor, suggesting that their dendrites can provide “private” feedback to cones, for instance, to shape the temporal filtering properties of the cone synapse.

scholarly journals Prion-induced photoreceptor degeneration begins with misfolded prion protein accumulation in cones at two distinct sites: cilia and ribbon synapses

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
James F. Striebel ◽  
Brent Race ◽  
Jacqueline M. Leung ◽  
Cindi Schwartz ◽  
Bruce Chesebro
Keyword(s):  
Retinitis Pigmentosa ◽  
Prion Protein ◽  
Bipolar Cell ◽  
Brain Diseases ◽  
Protein Accumulation ◽  
Post Inoculation ◽  
Rods And Cones ◽  
Ribbon Synapses ◽  
Cell Processes ◽  
Prpsc Deposition

AbstractAccumulation of misfolded host proteins is central to neuropathogenesis of numerous human brain diseases including prion and prion-like diseases. Neurons of retina are also affected by these diseases. Previously, our group and others found that prion-induced retinal damage to photoreceptor cells in mice and humans resembled pathology of human retinitis pigmentosa caused by mutations in retinal proteins. Here, using confocal, epifluorescent and electron microscopy we followed deposition of disease-associated prion protein (PrPSc) and its association with damage to critical retinal structures following intracerebral prion inoculation. The earliest time and place of retinal PrPSc deposition was 67 days post-inoculation (dpi) on the inner segment (IS) of cone photoreceptors. At 104 and 118 dpi, PrPSc was associated with the base of cilia and swollen cone inner segments, suggesting ciliopathy as a pathogenic mechanism. By 118 dpi, PrPSc was deposited in both rods and cones which showed rootlet damage in the IS, and photoreceptor cell death was indicated by thinning of the outer nuclear layer. In the outer plexiform layer (OPL) in uninfected mice, normal host PrP (PrPC) was mainly associated with cone bipolar cell processes, but in infected mice, at 118 dpi, PrPSc was detected on cone and rod bipolar cell dendrites extending into ribbon synapses. Loss of ribbon synapses in cone pedicles and rod spherules in the OPL was observed to precede destruction of most rods and cones over the next 2–3 weeks. However, bipolar cells and horizontal cells were less damaged, indicating high selectivity among neurons for injury by prions. PrPSc deposition in cone and rod inner segments and on the bipolar cell processes participating in ribbon synapses appear to be critical early events leading to damage and death of photoreceptors after prion infection. These mechanisms may also occur in human retinitis pigmentosa and prion-like diseases, such as AD.

scholarly journals Center-surround interactions underlie bipolar cell motion sensing in the mouse retina

2021 ◽  
Author(s):  
Sarah Strauss ◽  
Maria M Korympidou ◽  
Yanli Ran ◽  
Katrin Franke ◽  
Timm Schubert ◽  
...  
Keyword(s):  
Bipolar Cell ◽  
Ganglion Cells ◽  
Receptive Fields ◽  
Amacrine Cells ◽  
Bipolar Cells ◽  
Mouse Retina ◽  
Motion Processing ◽  
Local Motion ◽  
Motion Sensing ◽  
Motion Sensitivity

Motion is a critical aspect of vision. We studied the representation of motion in mouse retinal bipolar cells and found, surprisingly, that some bipolar cells possess motion-sensing capabilities that rely on their center-surround receptive fields. Using a glutamate sensor, we directly observed motion-sensitive bipolar cell synaptic output, which was strongest for local motion and dependent on the motion's origin. We characterized bipolar cell receptive fields and found that there are motion and non-motion sensitive bipolar cell types, the majority being motion sensitive. Next, we used these bipolar cell receptive fields along with connectomics to design biophysical models of downstream cells. The models and experiments demonstrated that bipolar cells pass motion-sensitive excitation to starburst amacrine cells through direction-specific signals mediated by bipolar cells' center-surround receptive field structure. As bipolar cells provide excitation to most amacrine and ganglion cells, their motion sensitivity may contribute to motion processing throughout the visual system.

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