No impact of sex and age on beta‐adrenoceptor‐mediated inotropy in human right atrial trabeculae

2020 ◽  
Author(s):  
Simon Pecha ◽  
Bastiaan Geelhoed ◽  
Romy Kempe ◽  
Emanuel Berk ◽  
Andreas Engel ◽  
...  
Keyword(s):  
Right Atrial ◽  
Human Right ◽  
Beta Adrenoceptor

scholarly journals Post-operative atrial fibrillation is associated with a pre-existing structural and electrical substrate in human right atrial myocardium

2016 ◽  
Vol 220 ◽  
pp. 580-588 ◽  
Author(s):  
Junaid A.B. Zaman ◽  
Leanne Harling ◽  
Hutan Ashrafian ◽  
Ara Darzi ◽  
Nigel Gooderham ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Right Atrial ◽  
Atrial Myocardium ◽  
Human Right ◽  
Post Operative Atrial Fibrillation

Desflurane-induced postconditioning of diabetic human right atrial myocardium in vitro

2010 ◽  
Vol 36 (1) ◽  
pp. 21-28 ◽  
Author(s):  
S. Lemoine ◽  
C. Durand ◽  
L. Zhu ◽  
C. Ivasceau ◽  
O. Lepage ◽  
...  
Keyword(s):  
Right Atrial ◽  
Atrial Myocardium ◽  
Human Right

Na+-dependent activation of Na+-K+ pump in human myocardium during recovery from acidosis

1989 ◽  
Vol 256 (1) ◽  
pp. H256-H264 ◽  
Author(s):  
H. H. Rasmussen ◽  
E. J. Cragoe ◽  
R. E. ten Eick
Keyword(s):  
Cardiac Cells ◽  
Right Atrial ◽  
Equilibrium Potential ◽  
Resting Membrane Potential ◽  
Tyrode Solution ◽  
Human Right ◽  
Pump Activity ◽  
Acid Load ◽  
Right Atrial Appendage ◽  
Dimethyl Amiloride

In cardiac cells of some species, an intracellular Na+ load and enhanced electrogenic Na+ pumping can develop during recovery from acidosis. We examined whether this can also occur in human heart. Specimens of human right atrial appendage were incubated in cold (2 degrees C) NH4Cl-substituted (for NaCl) Tyrode solution and then transferred to warm (30 degrees C) Na+-Tyrode solution containing 20 mM K+ to induce an intracellular acid load. After transfer, resting membrane potential (Em) transiently hyperpolarized to a maximal level (Emax) of -58.6 +/- 1.3 mV (n = 8), a level significantly (P less than 0.001) more negative than the equilibrium potential for K+. Decreasing K+ conductance with 0.5 mM Ba2+ increased Emax to -74.0 +/- 2.7 mV (n = 6, P less than 0.001), indicating that the hyperpolarization was not due to efflux of NH+4 through K channels. Acetylstrophanthidin (0.5 microM) reduced Emax to -37.5 +/- 3.1 mV (n = 5, P less than 0.001), indicating that an increased level of Na+-K+ pump activity was involved in the hyperpolarization. The Na+-K+ pump-induced hyperpolarization was abolished (Emax = -22.6 +/- 1.6 mV, n = 8, P less than 0.001) by 10 microM 5-(N,N-dimethyl)amiloride and, when the extracellular Na+ concentration was reduced to 50 mM, by 50 mM Li+. These findings suggest that Na+-H+ exchange can produce a Na+ load which then can stimulate electrogenic Na+ pumping in human cardiac cells during recovery from acidosis.

scholarly journals Characterization of the anatomy and conduction velocities of the human right atrial flutter circuit determined by noncontact mapping

2001 ◽  
Vol 38 (2) ◽  
pp. 385-393 ◽  
Author(s):  
Richard J Schilling ◽  
Nicholas S Peters ◽  
Jeffrey Goldberger ◽  
Alan H Kadish ◽  
D.Wyn Davies
Keyword(s):  
Atrial Flutter ◽  
Right Atrial ◽  
Human Right ◽  
Noncontact Mapping ◽  
Conduction Velocities

Block of Na + /Ca 2+ exchanger by SEA0400 in human right atrial preparations from patients in sinus rhythm and in atrial fibrillation

2016 ◽  
Vol 788 ◽  
pp. 286-293 ◽  
Author(s):  
Torsten Christ ◽  
Peter P. Kovács ◽  
Karoly Acsai ◽  
Michael Knaut ◽  
Thomas Eschenhagen ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Sinus Rhythm ◽  
Right Atrial ◽  
Human Right

Ketamine Preconditions Isolated Human Right Atrial Myocardium

2005 ◽  
Vol 102 (6) ◽  
pp. 1190-1196 ◽  
Author(s):  
Jean-Luc Hanouz ◽  
Lan Zhu ◽  
Emmanuel Persehaye ◽  
Massimo Massetti ◽  
Gerard Babatasi ◽  
...  
Keyword(s):  
Adenosine Triphosphate ◽  
Enhanced Recovery ◽  
Human Myocardium ◽  
Right Atrial ◽  
Control Group ◽  
Force Of Contraction ◽  
Human Right ◽  
Adrenoceptor Antagonist ◽  
Racemic Ketamine

Background The authors examined the effect of ketamine and its S(+) isomer on isolated human myocardium submitted to hypoxia-reoxygenation in vitro. Methods The authors studied isometric contraction of human right atrial trabeculae suspended in an oxygenated Tyrode's modified solution at 34 degrees C. Ten minutes before a 30-min hypoxic period followed by a 60-min reoxygenation, muscles were exposed for 15 min to racemic ketamine and its S(+) isomer at 10, 10, and 10 m alone or in the presence of 8.10 m 5-hydroxydecanoate, 10 m HMR 1098 (sarcolemmal adenosine triphosphate-sensitive potassium channel antagonist), 10 m phentolamine (alpha-adrenoceptor antagonist), and 10 m propranolol (beta-adrenoceptor antagonist). Force of contraction at the end of the 60-min reoxygenation period was compared between groups (mean +/- SD). Results Ketamine (10 m: 85 +/- 4%; 10 m: 95 +/- 10%; 10 m: 94 +/- 14% of baseline) and S(+)-ketamine (10-6 m: 85 +/- 4%; 10 m: 91 +/- 16%; 10 m: 93 +/- 14% of baseline) enhanced recovery of force of contraction at the end of the reoxygenation period as compared with the control group (47 +/- 10% of baseline; P < 0.001). Ketamine-induced preconditioning at 10 m was inhibited by 5-hydroxydecanoate (60 +/- 16%; P < 0.001), HMR 1098 (60 +/- 14%; P < 0.001), phentolamine (56 +/- 12%; P < 0.001), and propranolol (60 +/- 7%; P < 0.001). Conclusions In vitro, ketamine preconditions isolated human myocardium, at least in part, via activation of adenosine triphosphate-sensitive potassium channels and stimulation of alpha- and beta-adrenergic receptors.

Etomidate Has No Effect on Hypoxia Reoxygenation and Hypoxic Preconditioning in Isolated Human Right Atrial Myocardium

2008 ◽  
Vol 107 (4) ◽  
pp. 1139-1144
Author(s):  
Jean-Luc Hanouz ◽  
Sandrine Lemoine ◽  
Lan Zhu ◽  
Olivier Lepage ◽  
Gerard Babatasi ◽  
...  
Keyword(s):  
Hypoxic Preconditioning ◽  
Right Atrial ◽  
Atrial Myocardium ◽  
Human Right ◽  
Hypoxia Reoxygenation
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