scholarly journals Effects of IKur blocker MK-0448 on human right atrial action potentials from patients in sinus rhythm and in permanent atrial fibrillation

2014 ◽  
Vol 5 ◽  
Author(s):  
Simone Loose ◽  
Judith Mueller ◽  
Erich Wettwer ◽  
Michael Knaut ◽  
John Ford ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Sinus Rhythm ◽  
Action Potentials ◽  
Right Atrial ◽  
Human Right ◽  
Permanent Atrial Fibrillation

Block of Na + /Ca 2+ exchanger by SEA0400 in human right atrial preparations from patients in sinus rhythm and in atrial fibrillation

2016 ◽  
Vol 788 ◽  
pp. 286-293 ◽  
Author(s):  
Torsten Christ ◽  
Peter P. Kovács ◽  
Karoly Acsai ◽  
Michael Knaut ◽  
Thomas Eschenhagen ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Sinus Rhythm ◽  
Right Atrial ◽  
Human Right

scholarly journals Downregulation of the calcium current in human right atrial myocytes from patients in sinus rhythm but with a high risk of atrial fibrillation

2008 ◽  
Vol 29 (9) ◽  
pp. 1190-1197 ◽  
Author(s):  
Sylvie Dinanian ◽  
Christophe Boixel ◽  
Christophe Juin ◽  
Jean-Sébastien Hulot ◽  
Alain Coulombe ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
High Risk ◽  
Sinus Rhythm ◽  
Calcium Current ◽  
Right Atrial ◽  
Atrial Myocytes ◽  
Human Right

scholarly journals Post-operative atrial fibrillation is associated with a pre-existing structural and electrical substrate in human right atrial myocardium

2016 ◽  
Vol 220 ◽  
pp. 580-588 ◽  
Author(s):  
Junaid A.B. Zaman ◽  
Leanne Harling ◽  
Hutan Ashrafian ◽  
Ara Darzi ◽  
Nigel Gooderham ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Right Atrial ◽  
Atrial Myocardium ◽  
Human Right ◽  
Post Operative Atrial Fibrillation

Comparison of expression of connexin in right atrial myocardium in patients with chronic atrial fibrillation versus those in sinus rhythm

2003 ◽  
Vol 91 (6) ◽  
pp. 678-683 ◽  
Author(s):  
Tomoko Nao ◽  
Tomoko Ohkusa ◽  
Yuji Hisamatsu ◽  
Noriko Inoue ◽  
Tomo Matsumoto ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Sinus Rhythm ◽  
Chronic Atrial Fibrillation ◽  
Right Atrial ◽  
Atrial Myocardium

scholarly journals Thoracoscopic infrared ablation to create a box lesion as a treatment for atrial fibrillation

2022 ◽  
Vol 17 (1) ◽  
Author(s):  
Hiroshi Kubota ◽  
Toshiya Ohtsuka ◽  
Mikio Ninomiya ◽  
Takahiro Nonaka ◽  
Motoyuki Hisagi ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Sinus Rhythm ◽  
Left Atrial Appendage ◽  
Thoracoscopic Surgery ◽  
Posterior Wall ◽  
Beating Heart ◽  
Bottom Line ◽  
Case Presentation ◽  
Permanent Atrial Fibrillation ◽  
Direct Current Cardioversion

Abstract Background Creating a box lesion in the posterior wall of the left atrium from the epicardial side of the beating heart remains a challenge. Although a transmural lesion can be created by applying radiofrequency (RF) energy at clampable sites, it is still difficult to create a transmural lesion at unclampable sites because the inner blood flow in the unclampable free wall weakens the thermal effect on the outside. Our aim was to apply the newly developed infrared coagulator to create linear transmural lesions on the beating heart thoracoscopically to treat atrial fibrillation (AF). Case presentation A 71-year-old male was referred to our hospital with a diagnosis of hypertrophic cardiomyopathy and permanent atrial fibrillation. The patient was first diagnosed with atrial fibrillation 20 years before. Direct current cardioversion had been performed every few years a total of four times, but sinus rhythm restoration had always been temporary. On February 27, 2020, thoracoscopic PV isolation together with infrared roof- and bottom-line ablation to create a box lesion and left atrial appendage amputation (LAAA) were performed. The coagulator could be applied to clinical thoracoscopic surgery to successfully create a box lesion without any complication. The patient restored a regular sinus rhythm, it has been maintained for eleven months, and there have been no adverse events. Conclusions The infrared coagulator might have enough potential to create transmural lesions on the beating heart in thoracoscopic AF surgery.

Comparison of Large and Small Doses of Radioactive 131I in the Treatment of Patients with Cardiac Damage Associated with Thyrotoxicosis

1971 ◽  
Vol 10 (01) ◽  
pp. 55-68
Author(s):  
V. Felt ◽  
S. Váňa ◽  
J. Němec ◽  
C. Šilink
Keyword(s):  
Atrial Fibrillation ◽  
Sinus Rhythm ◽  
Paroxysmal Atrial Fibrillation ◽  
Favourable Effect ◽  
Cardiac Damage ◽  
Permanent Atrial Fibrillation ◽  
High Incidence ◽  
Diuretic Drugs ◽  
Small Doses ◽  
Diffuse Goiter

SummaryA comparison of the effect of large and small doses of radioiodine in patients with cardiac thyrotoxicosis revealed that after large doses thyrotoxicosis recedes more rapidly but is associated with a high incidence of hypothyroidism in subsequent years. After small doses the incidence of hypothyroidism is smaller; there is, however, a high percentage of persisting thyrotoxicoses. The sensitivity to radioiodine is higher in diffuse goiter, in small goiters, and after thyroidectomy.Large and small doses have approximately the same effect on the regression of decompensation and the incidence of paroxysmal atrial fibrillation, provided that treatment is supplemented by thyrostatic, antiarrhythmic, cardiotonic, and diuretic drugs. Larger doses of radioiodine had a more favourable effect on the reversion to sinus rhythm in patients with permanent atrial fibrillation.

An automated hybrid bioelectronic system for autogenous restoration of sinus rhythm in atrial fibrillation

2019 ◽  
Vol 11 (481) ◽  
pp. eaau6447 ◽  
Author(s):  
Emile C. A. Nyns ◽  
René H. Poelma ◽  
Linda Volkers ◽  
Jaap J. Plomp ◽  
Cindy I. Bart ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Sinus Rhythm ◽  
Transgene Expression ◽  
Light Emitting Diode ◽  
Right Atrial ◽  
Adult Rats ◽  
Light Emitting ◽  
Ambulatory Treatment ◽  
Rapid Restoration ◽  
Adenoassociated Virus

Because of suboptimal therapeutic strategies, restoration of sinus rhythm in symptomatic atrial fibrillation (AF) often requires in-hospital delivery of high-voltage shocks, thereby precluding ambulatory AF termination. Continuous, rapid restoration of sinus rhythm is desired given the recurring and progressive nature of AF. Here, we present an automated hybrid bioelectronic system for shock-free termination of AF that enables the heart to act as an electric current generator for autogenous restoration of sinus rhythm. We show that local, right atrial delivery of adenoassociated virus vectors encoding a light-gated depolarizing ion channel results in efficient and spatially confined transgene expression. Activation of an implanted intrathoracic light-emitting diode device allows for termination of AF by illuminating part of the atria. Combining this newly obtained antiarrhythmic effector function of the heart with the arrhythmia detector function of a machine-based cardiac rhythm monitor in the closed chest of adult rats allowed automated and rapid arrhythmia detection and termination in a safe, effective, repetitive, yet shock-free manner. These findings hold translational potential for the development of shock-free antiarrhythmic device therapy for ambulatory treatment of AF.

Abstract 5891: Incidence and Prognostic impact of Spontaneous Conversion to Sinus Rhythm in Patients with Permanent Atrial Fibrillation treated with Cardiac Resynchronization Devices

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Maurizio Gasparini ◽  
Christophe Leclercq ◽  
Aysha Arshad ◽  
François Regoli ◽  
Arnaud Rosier ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Sinus Rhythm ◽  
Nyha Class ◽  
Total Mortality ◽  
Cardiac Resynchronization ◽  
Prognostic Impact ◽  
Permanent Atrial Fibrillation ◽  
Lead Placement ◽  
6Mwt Distance

INTRODUCTION : Anecdotal reports of spontaneous resumption to stable sinus rhythm (SR) of heart failure (HF) patients with permanent atrial fibrillation (PeAF) after cardiac resynchronization therapy (CRT) have been reported. If this incidence is appreciable, additional interventions may be indicated including placement of an atrial lead. METHODS: We retrospectively reviewed patients with PeAF who received CRT devices; standard CRT indications were applied. PeAF was defined as AF present for more than 1 year refractory to any rhythm control efforts. Rhythm was sampled at each follow-up visit, generally every 6 months. RESULTS: In total, 345 patients with PeAF were implanted with CRT devices (CRT-D 48%); mean age was 70±9 yrs and mostly male gender (83%). Ischemic HF was present in 154 patients (45%). Mean NYHA class was 3,1±0,5, 6MWT distance 308±113 meters, QRS 156±39 ms, LVEF 28±7%, and LVEDD 65±9 mm. PeAF had been present for 2,1 ± 1.6 years. Over a follow-up of 29 ± 24 months, 34 (9,9%) patients spontaneously reverted to stable (> 3 months) SR. Most SR resumptions occurred within the 1 st year after CRT (28/34, 82%), but also occured even after 5 years (2/34). Mortality rate was 20,4 for PeAF compared to 2,5 per 100 patients-year for SR resumption (Log Rank p=0.004, see figure ) (HR= 0.13, 95% CI 0.031–0.512, p< 0.0001). CONCLUSION : Spontaneous resumption to SR in HF patients with PeAF treated with CRT was observed in roughly 10% of cases, generally within 1 year from implant. SR resumption was associated with a significant 87% reduction of total mortality. Identification of predictors for return of SR may be useful to guide routine atrial lead placement in some patients.

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