The discovery of non-adrenergic, non-cholinergic transmission: reply to the criticisms of G. Burnstock (2013) (GB) and Abbracchioet al. (2013) (Aet al.) of M. Bennett's (MB) account of this history in Acta Physiol (2013) Feb; 207(2):236-43

2013 ◽  
Vol 208 (4) ◽  
pp. 292-293 ◽  
Author(s):  
M. R. Bennett
Keyword(s):  
Cholinergic Transmission ◽  
Acta Physiol

scholarly journals Rapid multi-directed cholinergic transmission in the central nervous system

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Santhosh Sethuramanujam ◽  
Akihiro Matsumoto ◽  
Geoff deRosenroll ◽  
Benjamin Murphy-Baum ◽  
J Michael McIntosh ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Ganglion Cells ◽  
Release Site ◽  
Amacrine Cells ◽  
Global Scale ◽  
Cholinergic Transmission ◽  
Data Set ◽  
The Central Nervous System ◽  
Synaptic Mechanisms

AbstractIn many parts of the central nervous system, including the retina, it is unclear whether cholinergic transmission is mediated by rapid, point-to-point synaptic mechanisms, or slower, broad-scale ‘non-synaptic’ mechanisms. Here, we characterized the ultrastructural features of cholinergic connections between direction-selective starburst amacrine cells and downstream ganglion cells in an existing serial electron microscopy data set, as well as their functional properties using electrophysiology and two-photon acetylcholine (ACh) imaging. Correlative results demonstrate that a ‘tripartite’ structure facilitates a ‘multi-directed’ form of transmission, in which ACh released from a single vesicle rapidly (~1 ms) co-activates receptors expressed in multiple neurons located within ~1 µm of the release site. Cholinergic signals are direction-selective at a local, but not global scale, and facilitate the transfer of information from starburst to ganglion cell dendrites. These results suggest a distinct operational framework for cholinergic signaling that bears the hallmarks of synaptic and non-synaptic forms of transmission.

scholarly journals Characterization of the 5-HT receptor potentiating neuromuscular cholinergic transmission in strips of human isolated detrusor muscle

1994 ◽  
Vol 113 (1) ◽  
pp. 1-2 ◽  
Author(s):  
M. Tonini ◽  
E. Messori ◽  
G.P. Franceschetti ◽  
C.A. Rizzi ◽  
A.F. Castoldi ◽  
...  
Keyword(s):  
Detrusor Muscle ◽  
Cholinergic Transmission

Choline transporters, cholinergic transmission and cognition

2005 ◽  
Vol 6 (1) ◽  
pp. 48-56 ◽  
Author(s):  
Martin Sarter ◽  
Vinay Parikh
Keyword(s):  
Cholinergic Transmission
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