National population-based cohort study found that visual-motor integration was commonly affected in extremely preterm born children at six-and-a-half years

2018 ◽  
Vol 107 (5) ◽  
pp. 831-837 ◽  
Author(s):  
Jenny Bolk ◽  
Ylva Fredriksson Kaul ◽  
Lena Hellström-Westas ◽  
Karin Stjernqvist ◽  
Nelly Padilla ◽  
...  
Keyword(s):  
Cohort Study ◽  
Population Based ◽  
National Population ◽  
Visual Motor Integration ◽  
Extremely Preterm ◽  
Visual Motor ◽  
Preterm Born

scholarly journals Association between perinatal interventional activity and 2-year outcome of Swiss extremely preterm born infants: a population-based cohort study

BMJ Open ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. e024560 ◽  
Author(s):  
Mark Adams ◽  
Thomas M Berger ◽  
Cristina Borradori-Tolsa ◽  
Myriam Bickle-Graz ◽  
Sebastian Grunt ◽  
...  
Keyword(s):  
Cohort Study ◽  
Intensive Care ◽  
Neonatal Intensive Care ◽  
Neurodevelopmental Outcome ◽  
Neonatal Morbidity ◽  
Population Based ◽  
Neonatal Intensive Care Units ◽  
Extremely Preterm ◽  
Neurodevelopmental Impairment ◽  
Preterm Born

ObjectivesTo investigate if centre-specific levels of perinatal interventional activity were associated with neonatal and neurodevelopmental outcome at 2 years of age in two separately analysed cohorts of infants: cohort A born at 22–25 and cohort B born at 26–27 gestational weeks, respectively.DesignGeographically defined, retrospective cohort study.SettingAll nine level III perinatal centres (neonatal intensive care units and affiliated obstetrical services) in Switzerland.PatientsAll live-born infants in Switzerland in 2006–2013 below 28 gestational weeks, excluding infants with major congenital malformation.Outcome measuresOutcomes at 2 years corrected for prematurity were mortality, survival with any major neonatal morbidity and with severe-to-moderate neurodevelopmental impairment (NDI).ResultsCohort A associated birth in a centre with high perinatal activity with low mortality adjusted OR (aOR 0.22; 95% CI 0.16 to 0.32), while no association was observed with survival with major morbidity (aOR 0.74; 95% CI 0.46 to 1.19) and with NDI (aOR 0.97; 95% CI 0.46 to 2.02). Median age at death (8 vs 4 days) and length of stay (100 vs 73 days) were higher in high than in low activity centres. The results for cohort B mirrored those for cohort A.ConclusionsCentres with high perinatal activity in Switzerland have a significantly lower risk for mortality while having comparable outcomes among survivors. This confirms the results of other studies but in a geographically defined area applying a more restrictive approach to initiation of perinatal intensive care than previous studies. The study adds that infants up to 28 weeks benefited from a higher perinatal activity and why further research is required to better estimate the added burden on children who ultimately do not survive.

scholarly journals Visual–motor integration and fine motor skills at 6½ years of age and associations with neonatal brain volumes in children born extremely preterm in Sweden: a population-based cohort study

BMJ Open ◽  
2018 ◽  
Vol 8 (2) ◽  
pp. e020478 ◽  
Author(s):  
Jenny Bolk ◽  
Nelly Padilla ◽  
Lea Forsman ◽  
Lina Broström ◽  
Kerstin Hellgren ◽  
...  
Keyword(s):  
Motor Skills ◽  
Population Based ◽  
Fine Motor ◽  
Fine Motor Skills ◽  
Neonatal Brain ◽  
Brain Volumes ◽  
Visual Motor Integration ◽  
Morphometric Analyses ◽  
Extremely Preterm ◽  
Visual Motor

ObjectivesThis exploratory study aimed to investigate associations between neonatal brain volumes and visual–motor integration (VMI) and fine motor skills in children born extremely preterm (EPT) when they reached 6½ years of age.SettingProspective population-based cohort study in Stockholm, Sweden, during 3 years.ParticipantsAll children born before gestational age, 27 weeks, during 2004–2007 in Stockholm, without major morbidities and impairments, and who underwent MRI at term-equivalent age.Main outcome measuresBrain volumes were calculated using morphometric analyses in regions known to be involved in VMI and fine motor functions. VMI was assessed with The Beery-Buktenica Developmental Test of Visual–Motor Integration—sixth edition and fine motor skills were assessed with the manual dexterity subtest from the Movement Assessment Battery for Children—second edition, at 6½ years. Associations between the brain volumes and VMI and fine motor skills were evaluated using partial correlation, adjusted for total cerebral parenchyma and sex.ResultsOut of 107 children born at gestational age <27 weeks, 83 were assessed at 6½ years and 66/83 were without major brain lesions or cerebral palsy and included in the analyses. A representative subsample underwent morphometric analyses: automatic segmentation (n=34) and atlas-based segmentation (n=26). The precentral gyrus was associated with both VMI (r=0.54, P=0.007) and fine motor skills (r=0.54, P=0.01). Associations were also seen between fine motor skills and the volume of the cerebellum (r=0.42, P=0.02), brainstem (r=0.47, P=0.008) and grey matter (r=−0.38, P=0.04).ConclusionsNeonatal brain volumes in areas known to be involved in VMI and fine motor skills were associated with scores for these two functions when children born EPT without major brain lesions or cerebral palsy were evaluated at 6½ years of age. Establishing clear associations between early brain volume alterations and later VMI and/or fine motor skills could make early interventions possible.

scholarly journals Pregnancy, delivery and neonatal complications in women with schizophrenia: a national population-based cohort study

2021 ◽  
pp. 100209
Author(s):  
Cyprien FABRE ◽  
Vanessa PAULY ◽  
Karine BAUMSTARCK ◽  
Damien ETCHECOPAR-ETCHART ◽  
Veronica ORLEANS ◽  
...  
Keyword(s):  
Cohort Study ◽  
Population Based ◽  
Neonatal Complications ◽  
National Population
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