scholarly journals Sleep problems in children with dyslexia: understanding the role of sleep in neurocognitive development through the lens of developmental disorders

2016 ◽  
Vol 105 (9) ◽  
pp. 999-1000 ◽  
Author(s):  
Faye R. H. Smith ◽  
Lisa M. Henderson
Keyword(s):  
Developmental Disorders ◽  
Sleep Problems ◽  
Neurocognitive Development

Sleep Problems During the Preschool Years and Beyond as a Marker of Risk and Resilience in Substance Use

2018 ◽  
Author(s):  
Maria M. Wong
Keyword(s):  
Substance Use ◽  
Alcohol Use ◽  
Sleep Problems ◽  
Problem Drinking ◽  
Alcohol Problems ◽  
Risk And Resilience ◽  
Regulatory Processes ◽  
Sleep Physiology ◽  
Before And After

Individuals with alcohol problems have well-described disturbances of sleep, but the development of these disturbances both before and after the onset of problem drinking is poorly understood. This chapter first discusses sleep physiology and its measurement in humans. It then examines the functions of sleep and its role in development. Next, it reviews recent research on the relationship between sleep and alcohol use and related problems. Whereas sleep problems (e.g., difficulties falling or staying asleep) increase the risk of early onset of alcohol use and related problems, sleep rhythmicity promotes resilience to the development of alcohol use disorder and problem substance use. Based on existing research, this chapter proposes a theoretical model of sleep and alcohol use, highlighting the role of self-regulatory processes as mediators of this relationship.

scholarly journals SUMOylation Negatively Regulates Angiogenesis by Targeting Endothelial NOTCH Signaling

2017 ◽  
Vol 121 (6) ◽  
pp. 636-649 ◽  
Author(s):  
Xiaolong Zhu ◽  
Sha Ding ◽  
Cong Qiu ◽  
Yanna Shi ◽  
Lin Song ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Cell Fate ◽  
Developmental Disorders ◽  
Interaction Mechanism ◽  
Growth Factor Receptor ◽  
Vascular Diseases ◽  
Cell Interaction ◽  
Protein Signaling

Rationale: The highly conserved NOTCH (neurogenic locus notch homolog protein) signaling pathway functions as a key cell–cell interaction mechanism controlling cell fate and tissue patterning, whereas its dysregulation is implicated in a variety of developmental disorders and cancers. The pivotal role of endothelial NOTCH in regulation of angiogenesis is widely appreciated; however, little is known about what controls its signal transduction. Our previous study indicated the potential role of post-translational SUMO (small ubiquitin-like modifier) modification (SUMOylation) in vascular disorders. Objective: The aim of this study was to investigate the role of SUMOylation in endothelial NOTCH signaling and angiogenesis. Methods and Results: Endothelial SENP1 (sentrin-specific protease 1) deletion, in newly generated endothelial SENP1 (the major protease of the SUMO system)–deficient mice, significantly delayed retinal vascularization by maintaining prolonged NOTCH1 signaling, as confirmed in cultured endothelial cells. An in vitro SUMOylation assay and immunoprecipitation revealed that when SENP1 associated with N1ICD (NOTCH1 intracellular domain), it functions as a deSUMOylase of N1ICD SUMOylation on conserved lysines. Immunoblot and immunoprecipitation analyses and dual-luciferase assays of natural and SUMO-conjugated/nonconjugated NOTCH1 forms demonstrated that SUMO conjugation facilitated NOTCH1 cleavage. This released N1ICD from the membrane and stabilized it for translocation to the nucleus where it functions as a cotranscriptional factor. Functionally, SENP1-mediated NOTCH1 deSUMOylation was required for NOTCH signal activation in response to DLL4 (Delta-like 4) stimulation. This in turn suppressed VEGF (vascular endothelial growth factor) receptor signaling and angiogenesis, as evidenced by immunoblotted signaling molecules and in vitro angiogenesis assays. Conclusions: These results establish reversible NOTCH1 SUMOylation as a regulatory mechanism in coordinating endothelial angiogenic signaling; SENP1 acts as a critical intrinsic mediator of this process. These findings may apply to NOTCH-regulated biological events in nonvascular tissues and provide a novel therapeutic strategy for vascular diseases and tumors.

scholarly journals An abundance of developmental anomalies and abnormalities in Pleistocene people

2018 ◽  
Vol 115 (47) ◽  
pp. 11941-11946 ◽  
Author(s):  
Erik Trinkaus
Keyword(s):  
Fossil Record ◽  
Elevated Level ◽  
Developmental Disorders ◽  
Upper Paleolithic ◽  
Developmental Changes ◽  
Single Factor ◽  
Developmental Abnormalities ◽  
Low Probability ◽  
Developmental Variants

Diverse developmental abnormalities and anomalous features are evident in the PleistoceneHomofossil record, varying from minor but rare dental, vertebral, and carpal variants to exceptional systemic disorders. There are currently 75 documented anomalies or abnormalities from 66 individuals, spanning the Pleistocene but primarily from the Late Pleistocene Middle and Upper Paleolithic with their more complete skeletal remains. The expected probabilities of finding these variants or developmental disorders vary from <5% to <0.0001%, based on either recent human incidences or relevant Pleistocene sample distributions. Given the modest sample sizes available for the skeletal or dental elements in question, especially if the samples are appropriately limited in time and geography, the cumulative multiplicative probability of finding these developmental changes is vanishingly small. These data raise questions regarding social survival abilities, differing mortuary treatments of the biologically unusual, the role of ubiquitous stress among these Pleistocene foragers, and their levels of consanguinity. No single factor sufficiently accounts for the elevated level of these developmental variants or the low probability of finding them in the available paleontological record.

The Role of Musical Development in Early Language Acquisition

2018 ◽  
pp. 565-591
Author(s):  
Anthony Brandt ◽  
L. Robert Slevc ◽  
Molly Gebrian
Keyword(s):  
Language Acquisition ◽  
Cultural Transmission ◽  
Developmental Disorders ◽  
Native Language ◽  
Current Understanding ◽  
Early Language ◽  
Music And Language ◽  
Language And Music ◽  
Infant Brain

Language and music are readily distinguished by adults, but there is growing evidence that infants first experience speech as a special type of music. By listening to the phonemic inventory and prosodic patterns of their caregivers’ speech, infants learn how their native language is composed, later bootstrapping referential meaning onto this musical framework. Our current understanding of infants’ sensitivities to the musical features of speech, the co-development of musical and linguistic abilities, and shared developmental disorders, supports the view that music and language are deeply entangled in the infant brain and modularity emerges over the course of development. This early entanglement of music and language is crucial to the cultural transmission of language and children’s ability to learn any of the world’s tongues.

scholarly journals Disparities in Sleep Health among Adolescents: The Role of Sex, Age, and Migration

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Maria Jose Miguez ◽  
Diego Bueno ◽  
Caroline Perez
Keyword(s):  
Sleep Disturbances ◽  
First Generation ◽  
Sleep Problems ◽  
Cultural Backgrounds ◽  
Use Of Technology ◽  
Sleep Debt ◽  
Adjusted Logistic Regression ◽  
Cultural Ecological ◽  
And Migration

Background. Disparities in sleep disturbances have been described in adults; nevertheless, among adolescents, data have yielded conflicting results. Therefore, analyses of our cohort study of 500 urban, normally developed Hispanic adolescents (10–18 years), aim to determine if rates of sleep debt differ between: (a) male and female adolescents, (b) US-born Hispanics and first-generation immigrant ethnic counterparts, and (c) specific activities that these teens trade for sleep. Participants’ weekday and weekend sleep patterns, along with the reasons for sleeping less than the recommended hours were recorded. Standardized surveys were used to gather information regarding sociodemographics, migration, acculturation, and medical history. Using the criteria set forth by the National Sleep Foundation, analyses indicated that sleep deprivation is a pervasive problem, with 75% in the preadolescents and 45% of the late adolescents exhibiting sleep problems. Females slept on average at least one hour less per day than their male counterparts (7 vs. 8 hours). The sleep problems were rooted in several overlapping causes, including use of technology, video games, studying, and employment. Nevertheless, reasons for sleep loss differed by gender and by immigrant status. Multivariable adjusted logistic regression analyses showed that females, US-born teens, and preadolescents had higher odds of being sleep deprived. Pediatricians and sleep experts should be aware of gender-specific causes and responses of sleep problems. Cultural ecological frameworks need to be considered, and clearly indicate that findings may not generalize to youth from other cultural backgrounds.

scholarly journals KNOWLEDGE AND THE ROLE OF CADRES IN THE IMPLEMENTATION OF EARLY DETECTION OF TODDLERS DEVELOPMENT USING KPSP

2017 ◽  
Vol 10 (1) ◽  
pp. 22
Author(s):  
Nuryanin Yani ◽  
Ayesha H.N, Nurwening T.W.
Keyword(s):  
Early Detection ◽  
Developmental Disorders ◽  
Early Childhood Development ◽  
Childhood Development ◽  
Rank Test ◽  
Cross Sectional ◽  
Independent Variable ◽  
Relationship Of

Introduction: The development of toddlers is noteworthy considering the population size is large enough. Early detection is an important development with KPSP carried out in an effort to facilitate early detection of developmental disorders that can be given early intervention and referral early in children, in the end the quality of a child's development may be optimal. Trained cadres have the authority to monitor the development of children with KPSP Method: cross sectional analytic approach. Population health cadres in the district Lembeyan with Random sampling techniques with independent variable knowledge and skills of cadres, the role of cadres in the implementation of early detection of early childhood development using KPSP as the dependent variable. Results: Correlation between knowledge and the role of cadres in the implementation of early detection of toddlers development using KPSP analyzed using Spearman Rank test with the results of 0565, while the role and the skills to 0.485 correlation value. Conclusion: there is a relationship of knowledge to the role of cadres and there is a relationship between skill to the role of cadres in the implementation of early detection of toddler development using KPSP. It is hoped the clinic routinely provide refresher material on monitoring developments and increasing the number of screening kit (infrastructure for monitoring developments).

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