Biochemical markers of bone resorption are present in human milk: implications for maternal and neonatal bone metabolism

2014 ◽  
Vol 103 (12) ◽  
pp. 1264-1269 ◽  
Author(s):  
Maria Bouroutzoglou ◽  
Ariadne Malamitsi-Puchner ◽  
Maria Boutsikou ◽  
Antonios Marmarinos ◽  
Stavroula Baka ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Human Milk ◽  
Bone Metabolism ◽  
Biochemical Markers ◽  
Markers Of Bone Resorption

Changes in bone metabolism associated with exposure to industrial vibration

2020 ◽  
pp. 766-766
Author(s):  
A. V. Sukhova ◽  
E. N. Kryuchkova
Keyword(s):  
Bone Mineral Density ◽  
Alkaline Phosphatase ◽  
Bone Resorption ◽  
Bone Formation ◽  
Bone Metabolism ◽  
Biochemical Markers ◽  
Mineral Density ◽  
Local Vibration ◽  
Markers Of Bone Formation

The influence of general and local vibration on bone remodeling processes is investigated. The interrelations between the long - term exposure of industrial vibration and indicators of bone mineral density (T-and Z-criteria), biochemical markers of bone formation (osteocalcin, alkaline phosphatase) and bone resorption (ionized calcium, calcium/creatinine) were established.

New biochemical markers of bone resorption in the study of postmenopausal osteoporosis

1997 ◽  
Vol 265 (2) ◽  
pp. 225-234 ◽  
Author(s):  
Concepción de la Piedra ◽  
Maria Luisa Traba ◽  
Casimira Dominguez Cabrera ◽  
Manuel Sosa Henríquez
Keyword(s):  
Bone Resorption ◽  
Postmenopausal Osteoporosis ◽  
Biochemical Markers ◽  
Markers Of Bone Resorption

Different responses of biochemical markers of bone resorption to bisphosphonate therapy in Paget disease

1995 ◽  
Vol 41 (11) ◽  
pp. 1592-1598 ◽  
Author(s):  
A Blumsohn ◽  
K E Naylor ◽  
A M Assiri ◽  
R Eastell
Keyword(s):  
Bone Resorption ◽  
Biochemical Markers ◽  
Type I Collagen ◽  
Bisphosphonate Therapy ◽  
Response To Therapy ◽  
Tartrate Resistant Acid Phosphatase ◽  
Type I ◽  
Paget Disease ◽  
Markers Of Bone Resorption ◽  
Total Alkaline

Abstract We examined the response of different biochemical markers of bone resorption to bisphosphonate therapy (400 mg of etidronate daily for 6 months) in mild Paget disease (n = 14). Urinary markers included hydroxyproline (OHP), total (T) and free (F) pyridinolines (Pyds) determined by HPLC, immunoreactive FPyds, immunoreactive TPyds, and the N- and C-terminal telopeptides of type I collage (NTx, CL). Serum measurements included tartrate-resistant acid phosphatase (TRAcP) and the C-terminal telopeptide of type I collagen (ICTP). ICTP and TRAcP showed a minimal response to therapy (% change at 6 months, -13.1 +/- 6.8 and -6.7 +/- 3.4, respectively). The response was greatest for urinary telopeptides (NTx and CL; % change -75.7 +/- 7.5 and -73.4 +/- 8.9, respectively). The response was somewhat greater for TPyds than for FPyds. We conclude that: (a) ICTP and TRAcP are unreliable indicators of changes in bone turnover; (b) oligopeptide-bound Pyds and telopeptide fragments of type I collagen in urine show a somewhat greater response to therapy than do FPyds and may be more sensitive indicators of bone resorption; and (c) as yet no evidence suggests that these markers are substantially better predictors of the clinical response to therapy than serum total alkaline phosphatase or urinary OHP. There are several problems with the interpretation of these measurements in Paget disease, and the clinical utility of these measurements remains uncertain.

scholarly journals The effect of dietary sodium intake on biochemical markers of bone metabolism in young women

1998 ◽  
Vol 79 (4) ◽  
pp. 343-350 ◽  
Author(s):  
Fiona Ginty ◽  
Albert Flynn ◽  
Kevin D. Cashman
Keyword(s):  
Bone Resorption ◽  
Young Women ◽  
Biochemical Markers ◽  
Sodium Intake ◽  
Dietary Sodium ◽  
Serum Samples ◽  
Bone Specific Alkaline Phosphatase ◽  
Markers Of Bone Turnover ◽  
Dietary Period ◽  
Markers Of Bone Resorption

To investigate the effect of a low (80 mmol/d) or high (180 mmol/d) Na intake for 14 d on biochemical markers of bone turnover in Na-sensitive and Na-non-sensitive healthy young women, twenty-nine subjects were screened for responsiveness of urinary Ca excretion to increasing dietary Na intake (40, 80, 120 and 200mmol/d for 7d). In a crossover study, the eight Na-sensitive and eight of the twenty-one Na-non-sensitive subjects were randomly assigned to diets containing either 80 or 180 mmol Na/d for 14 d followed by crossover to the alternative diet for a further 14 d. Dietary Ca was restricted to 12.5mmol/d throughout. During each dietary period, fasting morning first void urine samples (last 3 d) and fasting blood serum samples (morning of twelfth day) were collected. Increasing Na intake from 80 to 180 mmol/d increased urinary Na about twofold in both the Na-sensitive and Na-non-sensitive groups and increased urinary Ca excretion (by 73%) in the Na-sensitive group only. Biochemical markers of bone resorption (urinary pyridinoline and deoxypyridinoline) and bone formation (serum osteocalcin and bone-specific alkaline phosphatase;EC3.1.3.1) were unaffected by increasing dietary Na in either group. It is concluded that the Na-induced calciuria observed in the Na-sensitive healthy young women did not result in increased bone resorption or turnover and, despite restricted Ca intake, adaptation of dietary Ca absorption may have compensated for the increased urinary Ca loss.

Oral calcium suppresses biochemical markers of bone resorption in normal men

1994 ◽  
Vol 60 (6) ◽  
pp. 965-968 ◽  
Author(s):  
M Horowitz ◽  
J M Wishart ◽  
D Goh ◽  
H A Morris ◽  
A G Need ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Biochemical Markers ◽  
Oral Calcium ◽  
Normal Men ◽  
Markers Of Bone Resorption
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