scholarly journals Interpreting regional differences in neonatal outcomes for extremely preterm babies

2013 ◽  
Vol 103 (1) ◽  
pp. 4-5 ◽  
Author(s):  
Neil Marlow
Keyword(s):  
Regional Differences ◽  
Neonatal Outcomes ◽  
Extremely Preterm ◽  
Preterm Babies

scholarly journals 204 Regional Differences in peri- and Neonatal Outcomes of Extremely Preterm Infants in Sweden (Express)

2012 ◽  
Vol 97 (Suppl 2) ◽  
pp. A59-A59
Author(s):  
F. Serenius ◽  
G. Sjors ◽  
M. Blennow ◽  
V. Fellman ◽  
G. Holmstrom ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Regional Differences ◽  
Neonatal Outcomes ◽  
Extremely Preterm ◽  
Extremely Preterm Infants

Neonatal Outcomes in Extremely Preterm Newborns Admitted to Intensive Care after No Active Antenatal Management: A Population-Based Cohort Study

2018 ◽  
Vol 203 ◽  
pp. 150-155 ◽  
Author(s):  
Caroline Diguisto ◽  
Laurence Foix L'Helias ◽  
Andrei S. Morgan ◽  
Pierre-Yves Ancel ◽  
Gilles Kayem ◽  
...  
Keyword(s):  
Cohort Study ◽  
Intensive Care ◽  
Population Based ◽  
Neonatal Outcomes ◽  
Extremely Preterm ◽  
Antenatal Management ◽  
Preterm Newborns

scholarly journals Intensity of perinatal care for extremely preterm babies and outcomes at a higher gestational age: evidence from the EPIPAGE-2 cohort study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Andrei Scott Morgan ◽  
Babak Khoshnood ◽  
Caroline Diguisto ◽  
Laurence Foix L’Helias ◽  
Laetitia Marchand-Martin ◽  
...  
Keyword(s):  
Gestational Age ◽  
Neonatal Intensive Care ◽  
Perinatal Care ◽  
Sensitivity Analyses ◽  
Intensity Level ◽  
Free Survival ◽  
Mortality And Morbidity ◽  
Antenatal Steroids ◽  
Extremely Preterm ◽  
Preterm Babies

Abstract Background Perinatal decision-making affects outcomes for extremely preterm babies (22–26 weeks’ gestational age (GA)): more active units have improved survival without increased morbidity. We hypothesised such units may gain skills and expertise meaning babies at higher gestational ages have better outcomes than if they were born elsewhere. We examined mortality and morbidity outcomes at age two for babies born at 27–28 weeks’ GA in relation to the intensity of perinatal care provided to extremely preterm babies. Methods Fetuses from the 2011 French national prospective EPIPAGE-2 cohort, alive at maternal admission to a level 3 hospital and delivered at 27–28 weeks’ GA, were included. Morbidity-free survival (survival without sensorimotor (blindness, deafness or cerebral palsy) disability) and overall survival at age two were examined. Sensorimotor disability and Ages and Stages Questionnaire (ASQ) result below threshold among survivors were secondary outcomes. Perinatal care intensity level was based on birth hospital, grouped using the ratio of 24–25 weeks’ GA babies admitted to neonatal intensive care to fetuses of the same gestation alive at maternal admission. Sensitivity analyses used ratios based upon antenatal steroids, Caesarean section, and newborn resuscitation. Multiple imputation was used for missing data; hierarchical logistic regression accounted for births nested within centres. Results 633 of 747 fetuses (84.7%) born at 27–28 weeks’ GA survived to age two. There were no differences in survival or morbidity-free survival: respectively, fully adjusted odds ratios were 0.96 (95% CI: 0.54 to 1.71) and 1.09 (95% CI: 0.59 to 2.01) in medium and 1.12 (95% CI: 0.63 to 2.00) and 1.16 (95% CI: 0.62 to 2.16) in high compared to low-intensity hospitals. Among survivors, there were no differences in sensorimotor disability or ASQ below threshold. Sensitivity analyses were consistent with the main results. Conclusions No difference was seen in survival or morbidity-free survival at two years of age among fetuses alive at maternal hospital admission born at 27–28 weeks’ GA, or in sensorimotor disability or presence of an ASQ below threshold among survivors. There is no evidence for an impact of intensity of perinatal care for extremely preterm babies on births at a higher gestational age.

scholarly journals The Influence of Early Nutrition on Brain Growth and Neurodevelopment in Extremely Preterm Babies: A Narrative Review

Nutrients ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 2029 ◽  
Author(s):  
Barbara E. Cormack ◽  
Jane E. Harding ◽  
Steven P. Miller ◽  
Frank H. Bloomfield
Keyword(s):  
Current Knowledge ◽  
Narrative Review ◽  
Neurodevelopmental Outcomes ◽  
Nutrition Research ◽  
Increased Risk ◽  
Extremely Preterm ◽  
Research Findings ◽  
Preterm Babies ◽  
The Many ◽  
Meta Analyses

Extremely preterm babies are at increased risk of less than optimal neurodevelopment compared with their term-born counterparts. Optimising nutrition is a promising avenue to mitigate the adverse neurodevelopmental consequences of preterm birth. In this narrative review, we summarize current knowledge on how nutrition, and in particular, protein intake, affects neurodevelopment in extremely preterm babies. Observational studies consistently report that higher intravenous and enteral protein intakes are associated with improved growth and possibly neurodevelopment, but differences in methodologies and combinations of intravenous and enteral nutrition strategies make it difficult to determine the effects of each intervention. Unfortunately, there are few randomized controlled trials of nutrition in this population conducted to determine neurodevelopmental outcomes. Substantial variation in reporting of trials, both of nutritional intakes and of outcomes, limits conclusions from meta-analyses. Future studies to determine the effects of nutritional intakes in extremely preterm babies need to be adequately powered to assess neurodevelopmental outcomes separately in boys and girls, and designed to address the many potential confounders which may have clouded research findings to date. The development of minimal reporting sets and core outcome sets for nutrition research will aid future meta-analyses.

Mode of Delivery and Neonatal Outcomes in Extremely Preterm Vertex/Non-Vertex Twins

2020 ◽  
Author(s):  
Liran HIERSCH ◽  
Prakesh S. SHAH ◽  
Faiza KHURSHID ◽  
Edith MASSE ◽  
Kellie MURPHY ◽  
...  
Keyword(s):  
Mode Of Delivery ◽  
Neonatal Outcomes ◽  
Extremely Preterm

scholarly journals Impact of obstetric interventions on condition at birth in extremely preterm babies: evidence from a national cohort study

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Andrei S. Morgan ◽  
Neil Marlow ◽  
Elizabeth S. Draper ◽  
Zarko Alfirević ◽  
Enid M. Hennessy ◽  
...  
Keyword(s):  
Cohort Study ◽  
Extremely Preterm ◽  
National Cohort ◽  
Preterm Babies
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