Visceral fat accumulation and metabolic syndrome in children: the impact of Trp64Arg polymorphism of the beta3-adrenergic receptor gene

2013 ◽  
Vol 102 (6) ◽  
pp. 613-619 ◽  
Author(s):  
Kazuo Oguri ◽  
Toshiki Tachi ◽  
Toshio Matsuoka
Keyword(s):  
Metabolic Syndrome ◽  
Visceral Fat ◽  
Adrenergic Receptor ◽  
Receptor Gene ◽  
Fat Accumulation ◽  
Visceral Fat Accumulation ◽  
Trp64arg Polymorphism ◽  
The Impact ◽  
Adrenergic Receptor Gene

scholarly journals Relationship between Metabolic Syndrome and Trp64Arg Polymorphism of the .BETA.3-Adrenergic Receptor Gene in a General Sample: The Shigaraki Study

2006 ◽  
Vol 29 (11) ◽  
pp. 891-896 ◽  
Author(s):  
Shinji TAMAKI ◽  
Yasuyuki NAKAMURA ◽  
Yasuharu TABARA ◽  
Tomonori OKAMURA ◽  
Yoshikuni KITA ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Adrenergic Receptor ◽  
Receptor Gene ◽  
Trp64arg Polymorphism ◽  
Adrenergic Receptor Gene

scholarly journals Investigation Trp64Arg polymorphism of the beta 3-adrenergic receptor gene in nonobese women with polycystic ovarian syndrome

2020 ◽  
Author(s):  
Farideh Zafari Zangeneh ◽  
Maryam Sarmast Shoushtari ◽  
Sahar Shojaee ◽  
Elahe Aboutorabi
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Adrenergic Receptor ◽  
Polycystic Ovarian Syndrome ◽  
Receptor Gene ◽  
Gene Bank ◽  
Control Group ◽  
Trp64arg Polymorphism ◽  
Ovarian Syndrome ◽  
Adrenergic Receptor Gene

Background: Polycystic ovary syndrome (PCOS) is a multifactorial and heterogeneous disease that has a potent inheritable component based on familial clustering. Despite many studies in the genetic field of PCOS, the genes that are involved in the causes of this syndrome have not been thoroughly investigated. Objective: The purpose of this study was to establish the occurrence of the Trp64Arg polymorphism of beta3 adrenergic receptor in non-obese women with PCOS. Materials and Methods: This cross-sectional study was performed on 100 women with PCOS and normal women as the control group in Imam Khomeini Hospital of Tehran in 2016-2017. Peripheral blood sample (2 cc) was obtained from two groups for genomic DNA based on the gene bank. Polymorphisms were genotyped by of using ADRB3 Trp64Arg. Then the DNA was extracted by genomic kiagen kit. The primer was analyzed for PCR based on gene bank by using Primer3 software and then confirmed by primer Blast tool at NCBI site to conformity to the beta-3 adrenergic receptor gene. The protein changes were assessment by the Clastal W software. Results: The sequence analysis presented in NCBI, transcript variant 1, with the code NM_000025.2, shows changes in the amino acid sequence of exon 1 in women with PCOS. Polymorphism in the codon 64 encoding the amino acid tryptophan (W) occurred in the nucleotide c.T190C, which changed the nucleotide T to C and then the amino acid sequence of the tryptophan was altered to arginine pW64R. Conclusion: T-C polymorphism is evident in the codon 64 of the adrenergic β3 receptor in patients with PCOS. Therefore, Beta3 adrenergic receptor gene polymorphism (Thr164Ile) associates with this syndrome in nonobese women. Key words: Codon 64, Beta-3 adrenergic receptor, Polymorphism, Polycystic ovarian syndrome.

scholarly journals Population Approaches Targeting Metabolic Syndrome Focusing on Japanese Trials

Nutrients ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1430 ◽  
Author(s):  
Hitoshi Nishizawa ◽  
Iichiro Shimomura
Keyword(s):  
Primary Care ◽  
Metabolic Syndrome ◽  
Visceral Fat ◽  
Behavioral Interventions ◽  
Lifestyle Modification ◽  
Task Force ◽  
Clinical Importance ◽  
Fat Accumulation ◽  
Screening Programs ◽  
Visceral Fat Accumulation

The clinical importance of assessment of metabolic syndrome lies in the selection of individuals with multiple risk factors based on visceral fat accumulation, and helping them to reduce visceral fat. Behavioral modification by population approach is important, which adds support to the personal approach. The complexity of visceral fat accumulation requires multicomponent and multilevel intervention. Preparation of food and physical environments could be useful strategies for city planners. Furthermore, actions on various frameworks, including organizational, community, and policy levels, have been recently reported. There are universal public health screening programs and post-screening health educational systems in Japan, and diseases management programs in Germany. Understanding one’s own health status is important for motivation for lifestyle modification. The U.S. Preventive Services Task Force recommends that primary care practitioners screen all adults for obesity and offer behavioral interventions and intensive counseling. Established evidence-based guidelines for behavioral counseling are needed within the primary care setting.

The Trp64Arg Polymorphism of the β3-Adrenergic Receptor Gene Is Not Associated with Training-Induced Changes in Body Composition: The HERITAGE Family Study

2001 ◽  
Vol 9 (6) ◽  
pp. 337-341 ◽  
Author(s):  
Christophe Garenc ◽  
Louis Pérusse ◽  
Tuomo Rankinen ◽  
Jacques Gagnon ◽  
Arthur S. Leon ◽  
...  
Keyword(s):  
Body Composition ◽  
Adrenergic Receptor ◽  
Family Study ◽  
Receptor Gene ◽  
Trp64arg Polymorphism ◽  
Induced Changes ◽  
Adrenergic Receptor Gene
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