ATP‐binding cassette subfamily A‐1 (ABCA1) levels are increased in the aqueous humour of proliferative diabetic retinopathy patients

2020 ◽  
Author(s):  
Hyo Seon Yu ◽  
Eun Hee Hong ◽  
Yong Un Shin ◽  
Seong‐Ho Koh ◽  
Heeyoon Cho
Keyword(s):  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Aqueous Humour ◽  
Atp Binding ◽  
Atp Binding Cassette

scholarly journals Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Xinyuan Zhang ◽  
Kaiyue Wang ◽  
Ling Zhu ◽  
Qiyun Wang
Keyword(s):  
Diabetic Retinopathy ◽  
Cholesterol Metabolism ◽  
Underlying Mechanism ◽  
The Body ◽  
Plasma Lipoproteins ◽  
Atp Binding ◽  
Transport Pathway ◽  
Reverse Transport ◽  
Essential Components ◽  
Atp Binding Cassette

Cholesterol esters, synthesized from cholesterol with long-chain fatty acids, are essential components of plasma lipoproteins and cell membranes that participate in various metabolic processes in the body. Cholesterol can be excreted through the cholesterol reverse transport (RCT) pathway when excessive cholesterol is produced in the extrahepatic cells, which is regulated by the liver X receptor (LXR) and its downstream regulators ATP-binding cassette subfamily A member 1 (ABCA1) and ATP-binding cassette subfamily G member 1 (ABCG1) genes. Abnormal cholesterol metabolism is closely associated with the development of diabetic retinopathy (DR). However, the precise underlying mechanism of the RCT pathway in the pathogenesis of DR is still not fully understood. This review focused on cholesterol metabolism, with a particular emphasis on the RCT pathway and its correlation with the development of DR. Particular attention has been paid to the key regulators of the RCT pathway: LXR, ABCA1, and ABCG1 genes and their potential therapeutic targets in the management of DR.

scholarly journals Aqueous humour concentrations of TGF-β, PLGF and FGF-1 and total retinal blood flow in patients with early non-proliferative diabetic retinopathy

2016 ◽  
Vol 95 (3) ◽  
pp. e206-e211 ◽  
Author(s):  
Lee-Anne Khuu ◽  
Faryan Tayyari ◽  
Jeremy M. Sivak ◽  
John G. Flanagan ◽  
Shaun Singer ◽  
...  
Keyword(s):  
Blood Flow ◽  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Aqueous Humour ◽  
Retinal Blood Flow

Immunolocalization and funtional role of scavenger receptor BI (SR-BI) and ATP-binding cassette A1 (ABC1)

2001 ◽  
Vol 120 (5) ◽  
pp. A678-A678
Author(s):  
I SUC ◽  
M BENDAYAN ◽  
E DELVIN ◽  
L BRISSETTE ◽  
C GAROFALO ◽  
...  
Keyword(s):  
Scavenger Receptor ◽  
Atp Binding ◽  
Scavenger Receptor Bi ◽  
Atp Binding Cassette
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