Aqueous humour concentrations of TGF‐ β , PLGF and FGF‐1 and total retinal blood flow in patients with early non‐proliferative diabetic retinopathy

2017 ◽  
Vol 97 (3) ◽  
pp. e482-e482
Author(s):  
Shaolin Du ◽  
Lanli Ju ◽  
Wenkai Zheng
Keyword(s):  
Blood Flow ◽  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Aqueous Humour ◽  
Retinal Blood Flow

scholarly journals Aqueous humour concentrations of TGF-β, PLGF and FGF-1 and total retinal blood flow in patients with early non-proliferative diabetic retinopathy

2016 ◽  
Vol 95 (3) ◽  
pp. e206-e211 ◽  
Author(s):  
Lee-Anne Khuu ◽  
Faryan Tayyari ◽  
Jeremy M. Sivak ◽  
John G. Flanagan ◽  
Shaun Singer ◽  
...  
Keyword(s):  
Blood Flow ◽  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Aqueous Humour ◽  
Retinal Blood Flow

Effect of Panretinal Photocoagulation on Retinal Blood Flow in Proliferative Diabetic Retinopathy

Ophthalmology ◽  
1986 ◽  
Vol 93 (5) ◽  
pp. 590-595 ◽  
Author(s):  
Juan E. Grunwald ◽  
Charles E. Riva ◽  
Alexander J. Brucker ◽  
Stephen H. Sinclair ◽  
Benno L. Petrig
Keyword(s):  
Blood Flow ◽  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Retinal Blood Flow ◽  
Panretinal Photocoagulation

Effect of Panretinal Photocoagulation on Retinal Blood Flow in Proliferative Diabetic Retinopathy

Retina ◽  
1987 ◽  
Vol 7 (1) ◽  
pp. 58
Author(s):  
Juan E. Grunwald ◽  
Charles E. Riva ◽  
Alexander J. Brucker ◽  
Stephen H. Sinclair ◽  
Benno L. Petrig
Keyword(s):  
Blood Flow ◽  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Retinal Blood Flow ◽  
Panretinal Photocoagulation

Effect of Panretinal Photocoagulation on Retinal Blood Flow in Proliferative Diabetic Retinopathy

Retina ◽  
1987 ◽  
Vol 7 (1) ◽  
pp. 58
Author(s):  
Juan E. Grunwald ◽  
Charles E. Riva ◽  
Alexander J. Brucker ◽  
Stephen H. Sinclair ◽  
Benno L. Petrig
Keyword(s):  
Blood Flow ◽  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Retinal Blood Flow ◽  
Panretinal Photocoagulation

scholarly journals Two Cases of Proliferative Diabetic Retinopathy with Marked Sheathing of the Retinal Arteries following Vitrectomy

2017 ◽  
Vol 8 (1) ◽  
pp. 40-48
Author(s):  
Yuko Nishikawa ◽  
Seita Morishita ◽  
Kimitoshi Nakamura ◽  
Masanori Fukumoto ◽  
Hiroyuki Suzuki ◽  
...  
Keyword(s):  
Blood Flow ◽  
Optical Coherence Tomography ◽  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Silicone Oil ◽  
Vitreous Hemorrhage ◽  
Retinal Blood Flow ◽  
Retinal Arterioles ◽  
Retinal Artery ◽  
Silicone Oil Tamponade

Purpose: The aim of this paper was to report 2 patients (3 eyes) with proliferative diabetic retinopathy (PDR) who showed marked sheathing of the retinal arterioles that was ultimately attributed to calcification following vitrectomy. Cases: Case 1 involved a 65-year-old female with PDR who underwent bilateral vitrectomy for traction retinal detachment. Postoperatively, bilateral retinal redetachment (reRD) was observed. Sheathing of the retinal arterioles was observed at the same time, yet was not apparent preoperatively. Case 2 involved a 71-year-old female with PDR who underwent vitrectomy for vitreous hemorrhage. Postoperatively, reRD was observed, and fundus findings showed sheathing of the retinal arterioles. In both patients, silicone oil tamponade and retinopexy were performed at reoperation, but sheathing of the retinal arterioles persisted postoperatively. Fluorescein fundus angiography showed that retinal blood flow was maintained, and no vessel leakage occurred. In addition, no sheathing of the retinal veins was observed. Optical coherence tomography (OCT) showed a higher intensity for retinal arterioles with sheathing than for normal retinal arterioles. Conclusion: Vessel sheathing in our 2 patients (3 eyes) differed from the sheathing seen in vasculitis. Based on the hyperintensity on OCT, this sheathing may have been due to retinal artery calcification induced by hypoxia and inflammation associated with reRD.

scholarly journals Aqueous humor endothelin-1 and total retinal blood flow in patients with non-proliferative diabetic retinopathy

Eye ◽  
2017 ◽  
Vol 31 (10) ◽  
pp. 1443-1450 ◽  
Author(s):  
L-A Khuu ◽  
F Tayyari ◽  
J M Sivak ◽  
J G Flanagan ◽  
S Singer ◽  
...  
Keyword(s):  
Blood Flow ◽  
Diabetic Retinopathy ◽  
Aqueous Humor ◽  
Proliferative Diabetic Retinopathy ◽  
Retinal Blood Flow ◽  
Endothelin 1

scholarly journals Detection of significantly high vitreous concentrations of fatty acid-binding protein 4 in patients with proliferative diabetic retinopathy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kaku Itoh ◽  
Masato Furuhashi ◽  
Yosuke Ida ◽  
Hiroshi Ohguro ◽  
Megumi Watanabe ◽  
...  
Keyword(s):  
Blood Flow ◽  
Diabetic Retinopathy ◽  
Fatty Acid ◽  
Proliferative Diabetic Retinopathy ◽  
Ocular Blood Flow ◽  
Laser Speckle ◽  
Laser Speckle Flowgraphy ◽  
Fatty Acid Binding ◽  
High Positive Correlation ◽  
Blood Biochemical

AbstractThe fatty acid-binding protein4 (FABP4) and vascular endothelial growth factor A (VEGFA) play key roles in the metabolic and cardiovascular diseases, and proliferative diabetic retinopathy (PDR), respectively. To identify FABP4 in vitreous fluid in PDR, vitreous concentrations of FABP4 (V-FABP4) and VEGFA (V-VEGFA) from PDR (n = 20) and non-PDR (n = 20) patients were determined by Enzyme-Linked ImmunoSorbent Assays. The data, which included height and weight, systemic blood pressures, several blood biochemical parameters and blood flow at the optic nerve head (ONH) by laser speckle flowgraphy (LSFG) were collected. The levels of V-FABP4 and V-VEGFA were significantly higher in PDR patients than in non-PDR patients (P < 0.001) with a high positive correlation (r = 0.72, P < 0.001) between them. The findings were not affected by body mass index values and the presence of vitreous hemorrhaging. Among the clinical parameters, V-FABP4 correlated positively with creatinine and negatively with age and aspartate transaminase (AST) levels, while V-VEGFA correlated positively with fasting plasma glucose and hemoglobin A1c (HbA1c) levels but negatively with AST. Multiple regression analyses indicated that V-VEGFA, or V-FABP4, AST and HbA1c were independent predictors of V-FABP4 or V-VEGFA, respectively. Both were negatively correlated, but more evident in V-FABP4, with the ONH ocular blood flow.

Retinal Vascular Implications of Ocular Hypertension

2021 ◽  
Author(s):  
Fidan Jmor ◽  
John C. Chen
Keyword(s):  
Blood Flow ◽  
Diabetic Retinopathy ◽  
Intraocular Pressure ◽  
Vascular Anatomy ◽  
Flow Regulation ◽  
Retinal Blood Flow ◽  
Vein Occlusion ◽  
Ocular Perfusion ◽  
The Relationship ◽  
Central Retinal Vein

In this chapter, we review the basics of retinal vascular anatomy and discuss the physiologic process of retinal blood flow regulation. We then aim to explore the relationship between intraocular pressure and retinal circulation, taking into account factors that affect retinal hemodynamics. Specifically, we discuss the concepts of ocular perfusion pressure, baro-damage to the endothelium and transmural pressure in relation to the intraocular pressure. Finally, we demonstrate the inter-relationships of these factors and concepts in the pathogenesis of some retinal vascular conditions; more particularly, through examples of two common clinical pathologies of diabetic retinopathy and central retinal vein occlusion.

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