scholarly journals Prevalence of pterygium and identification of associated factors in a German population – results from the Gutenberg Health Study

2020 ◽  
Author(s):  
Ulrike Hampel ◽  
Joanna Wasielica‐Poslednik ◽  
Lisa Ries ◽  
Ruah Faysal ◽  
Andreas Schulz ◽  
...  
Keyword(s):  
Associated Factors ◽  
Health Study ◽  
German Population ◽  
Gutenberg Health Study

scholarly journals Vision-related quality of life considering both eyes: results from the German population-based Gutenberg Health Study (GHS)

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Stefan Nickels ◽  
Alexander K. Schuster ◽  
Heike Elflein ◽  
Christian Wolfram ◽  
Andreas Schulz ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Population Based ◽  
Health Study ◽  
German Population ◽  
Gutenberg Health Study ◽  
Related Quality

Refractive, corneal, and ocular residual astigmatism: distribution in a German population and age dependency—the Gutenberg Health Study

2017 ◽  
Vol 256 (2) ◽  
pp. 445-446
Author(s):  
Alexander Karl-Georg Schuster ◽  
Norbert Pfeiffer ◽  
Andreas Schulz ◽  
René Hoehn ◽  
Katharina A. Ponto ◽  
...  
Keyword(s):  
Health Study ◽  
German Population ◽  
Age Dependency ◽  
Ocular Residual Astigmatism ◽  
Gutenberg Health Study

scholarly journals Five-year cumulative incidence and progression of age-related macular degeneration: results from the German population-based Gutenberg Health Study (GHS)

2021 ◽  
Author(s):  
Christina A. Korb ◽  
Hisham Elbaz ◽  
Alexander K. Schuster ◽  
Stefan Nickels ◽  
Katharina A. Ponto ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Cumulative Incidence ◽  
Population Based ◽  
Age Related Macular Degeneration ◽  
Fundus Photography ◽  
Health Study ◽  
German Population ◽  
Gutenberg Health Study ◽  
Age Related

Abstract Purpose Age-related macular degeneration (AMD) is a major cause of visual impairment and blindness. This study evaluates the incidence and progression of AMD in a large German cohort. Methods The Gutenberg Health Study (GHS) is a population-based, prospective, observational cohort study in Germany that includes 15,010 participants between 35 and 74 years of age. The baseline examination, including fundus photography, was conducted between 2007 and 2012, and the 5-year follow-up examination was performed between 2012 and 2017. AMD grading of fundus photographs was performed according to the Rotterdam Eye Study classification. The 5-year cumulative incidence and progression of AMD were calculated. Poisson regression analysis was conducted to investigate factors associated with the cumulative incidence and progression of AMD. Results Six-thousand-eight-hundred-eighty-eight participants (49.8%, n = 3427 female) were included in the analysis. AMD prevalence was 8.5% [95% CI: 7.9–9.2%] at baseline and 10.3% [95% CI: 9.6–11.1%] at follow-up. The cumulative 5-year-incidence was 2.0% [1.7–2.4%]. AMD progression within 5 years was seen in 18.1% [95% CI: 15.1–21.5%] of the participants. AMD incidence and AMD progression were associated with higher age, for each 10-year increase in age, the risk of AMD doubles (RR = 2.30), and the risk of progression of the disease is increased by 1.6. while AMD incidence also with pseudophakic status. Conclusions In summary, this population-based sample provides substantial epidemiologic data from a large German cohort, including data on progression and cumulative incidence of macular degeneration in younger age groups. AMD progression over 5 years is common in the German population, 18.1% of subjects with AMD showed progression in at least one eye in this time frame and is associated with higher age. Nevertheless, although usually defined to occur over the age of 50, in this cohort AMD occurred in 0.5% and AMD progression occurred in 5.4% of those already affected in the youngest age group before 50 years of age.

scholarly journals Prevalence of corneal arcus and associated factors in a German population—Results from the Gutenberg Health Study

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0255893
Author(s):  
Joanna Wasielica-Poslednik ◽  
Ulrike Hampel ◽  
Lisa Ries ◽  
Ruah Faysal ◽  
Andreas Schulz ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Blood Pressure ◽  
Associated Factors ◽  
Economic Status ◽  
Anterior Segment ◽  
Health Study ◽  
Socio Economic Status ◽  
Gutenberg Health Study ◽  
Arterial Blood ◽  
Lipid Modifying Agents

Purpose We aimed to determine the prevalence of corneal arcus and to identify associated factors in the general population of Germany. Methods The Gutenberg Health Study (GHS) is a population-based cohort study in Germany, which includes an ophthalmological assessment. Refraction, distance-corrected visual acuity, non-contact tonometry and anterior segment imaging were performed for the five-year follow-up examination. Anterior segment photographs were graded for the presence of corneal arcus. Prevalence estimates were computed, and multivariable logistic regression analysis was applied to determine associated factors for corneal arcus including sex, age, spherical equivalent, central corneal thickness, intraocular pressure (IOP), socio-economic status, smoking, BMI, systolic and diastolic arterial blood pressure, HbA1c, HDL-C, LDL-C, triglyceride, and lipid modifying agents. Results A total of 9,850 right and 9,745 left eyes of 9,858 subjects (59.2±10.8 years), 49.0% females were included in this cross-sectional analysis. 21.1% of men (95%-CI: 20.0%– 22.3%) had a corneal arcus in at least one eye, and 16.9% (95%-CI: 15.9%– 18.0%) of women. In multivariable analyses, the presence of corneal arcus was associated with male gender (OR = 0.54 for female, p<0.0001), higher age (OR = 2.54 per decade, p<0.0001), smoking (OR = 1.59, p<0.0001), hyperopia (OR = 1.05 per diopter, p<0.0001), thinner cornea (OR = 0.994 per μm, p<0.0001), higher IOP (OR = 1.02, p = 0.039), higher HDL-C-level (OR = 2.13, p<0.0001), higher LDL-C-level (OR = 1.21, p<0.0001), and intake of lipid modifying agents (OR = 1.26, p = 0.0001). Arcus was not associated with socio-economic status, BMI, arterial blood pressure, and HbA1c. Conclusions Corneal arcus is a frequent alteration of the cornea in Germany and is associated with ocular parameters and systemic parameters of dyslipidemia.

scholarly journals Peripheral corneal thickness and associated factors – results from the population‐based German Gutenberg Health Study

2021 ◽  
Author(s):  
Achim Fieß ◽  
Susanne Marx‐Groß ◽  
Joanna Wasielica‐Poslednik ◽  
Markus Nagler ◽  
Irene Schmidtmann ◽  
...  
Keyword(s):  
Associated Factors ◽  
Corneal Thickness ◽  
Population Based ◽  
Health Study ◽  
Gutenberg Health Study

Prevalence of myopic maculopathy in the German population: results from the Gutenberg health study

2019 ◽  
pp. bjophthalmol-2019-315255 ◽  
Author(s):  
Susanne Hopf ◽  
Christina Korb ◽  
Stefan Nickels ◽  
Andreas Schulz ◽  
Thomas Münzel ◽  
...  
Keyword(s):  
Refractive Error ◽  
Population Based ◽  
Health Study ◽  
Multivariable Logistic Regression Analysis ◽  
German Population ◽  
Gutenberg Health Study ◽  
Diffuse Atrophy ◽  
Systemic Factors ◽  
Fundus Photographs ◽  
Myopic Maculopathy

AimsTo determine the prevalence of myopic maculopathy in the general population in Germany and to analyse potential associations with ocular and systemic factors.DesignThe Gutenberg Health Study is a population-based study, including 15 010 participants aged 35–74 years.MethodsMyopic maculopathy was graded in phakic eyes with spherical equivalent ≤−6 D by assessing fundus photographs according to a recent international photographic classification system (META-PM). 801 eyes of 519 participants (mean age 51.0±0.77 years) met the conditions and had gradable fundus photographs. Age-specific prevalence estimates were computed. Multivariable logistic regression analysis was used to assess associated factors with myopic maculopathy.ResultsMyopic maculopathy was present in 10.3% (95% CI 7.9 to 13.3) study participants. The prevalence was 8.6% (95% CI 6.1% to 11.9%) in the 397 right eyes and 8.7% (95% CI 6.2% to 12.0%) in the 404 left eyes. The most common type of pathology was diffuse atrophy (8.1%), followed by patchy atrophy (1.3%) and macular atrophy (0.5%); plus lesions were present in 3% (right eyes). Age (OR 1.07 per year, 95% CI 1.03 to 1.11, p<0.001), higher myopic refractive error (p<0.001), and male gender (p=0.02) were associated with myopic maculopathy, while cardiovascular risk factors and socioeconomic factors were not.ConclusionsThe prevalence of myopic maculopathy in the German population was 0.5%, and 10% in high myopic participants, aged 35–74 years. These population-based data are the first in Europe. Myopic maculopathy was related to severity of myopic refractive error and age.

scholarly journals Incidence of retinal detachment in Germany

2020 ◽  
Author(s):  
Eva Gerstenberger ◽  
Bernhard Stoffelns ◽  
Stefan Nickels ◽  
Thomas Münzel ◽  
Philipp S Wild ◽  
...  
Keyword(s):  
Risk Factors ◽  
Retinal Detachment ◽  
Cumulative Incidence ◽  
Population Based ◽  
Health Study ◽  
Computer Assisted ◽  
German Population ◽  
Gutenberg Health Study ◽  
Potential Risk Factors ◽  
Male Sex

Purpose: To investigate the incidence of retinal detachment in the German population and assess potential risk factors. Methods: The Gutenberg Health Study is a population-based cohort study in Mainz, Germany including subjects (n=15.010) with an age range from 35 to 74 years at baseline. Participants underwent a comprehensive ophthalmologic examination including distant-corrected visual acuity, refraction and slit-lamp examination at baseline. A computer-assisted telephone interview was conducted after 2.5 and 5 years. The 5-year cumulative incidence of retinal detachment was computed for the study sample and stratified on age decades. Risk factors were analyzed using logistic regression including age, sex, spherical equivalent, pseudophakia and prior laser retinal therapy. Results: 13.416 participants (age 52.2 ±10.7 years, 48.8% female) were included in this analysis. 28 subjects had a retinal detachment in one eye, no subject had a retinal detachment in both eyes. The 5-year cumulative incidence of retinal detachment was 0.21% (95%-confidence interval: 0.14 – 0.31%), the incidence rate was 42/100.000 person-years. Risk factors were male sex (OR= 4.16, p=0.004), pseudophakia (OR=3.93, p=0.045) and myopia (OR=1.31 per diopter myopia, p<0.0001), but not prior retinal laser therapy or age. Conclusion: The incidence of retinal detachment in Germany at age 35 to 74 years is comparable to estimates from neighboring European countries. Risk factors are male sex, pseudophakia and myopia.

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