scholarly journals Evaluation of two-dimensional Bruch's membrane opening minimum rim area for glaucoma diagnostics in a large patient cohort

2018 ◽  
Vol 97 (1) ◽  
pp. 60-67 ◽  
Author(s):  
Philip Enders ◽  
Werner Adler ◽  
David Kiessling ◽  
Vincent Weber ◽  
Friederike Schaub ◽  
...  
Keyword(s):  
Two Dimensional ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Patient Cohort ◽  
Large Patient Cohort ◽  
Large Patient ◽  
Bruch’S Membrane Opening ◽  
Glaucoma Diagnostics

Long Term Follow-up after Ovarian Borderline Tumor: Relapse and Survival in a large Patient Cohort

2008 ◽  
Vol 68 (S 01) ◽  
Author(s):  
MS Lenhard ◽  
S Mitterer ◽  
C Kümper ◽  
N Ditsch ◽  
K Friese ◽  
...  
Keyword(s):  
Borderline Tumor ◽  
Patient Cohort ◽  
Tumor Relapse ◽  
Large Patient Cohort ◽  
Large Patient ◽  
Long Term Follow Up

Bruch’s membrane opening-minimum rim width: An alternative OCT biomarker study for multiple sclerosis

2021 ◽  
pp. 112067212199663
Author(s):  
Kemal Turgay Özbilen ◽  
Tuncay Gündüz ◽  
Selva Nur Çukurova Kartal ◽  
Ali Ceyhun Gedik ◽  
Mefküre Eraksoy ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
High Sensitivity ◽  
The Novel ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Spectral Domain Oct ◽  
Neuroretinal Rim ◽  
Bruch’S Membrane Opening ◽  
The Difference ◽  
Therapeutic Decision Making

Purpose: Bruch’s membrane opening-minimum rim width (BMO-MRW) and RNFL measured using anatomic positioning system (APS-RNFL) are novel OCT methods and remained unexplored in MS patients. To investigate the novel parameters of spectral-domain OCT as an alternative biomarker in patients with multiple sclerosis (MS). Methods: Retrospective cohort study; participants consisted of relapsing-remitting MS (RRMS) patients and healthy controls (HC). Eyes were classified according to the presence of MS and previous optic neuritis (ON). Measurements of standard peripapillary RNFL (S-RNFL), BMO-MRW, and APS-RNFL were performed. Result: A total of 244 eyes of 122 participants (MS-patients: 63, HC: 59) were included in the study. Fifty-one eyes had a history of previous ON. In almost all measured parameters, neuroretinal rim thicknesses were observed the thinnest in eyes with ON history between all subgroups. S-RNFL and APS-RNFL techniques showed the difference in neuroretinal rim thickness in all three subjects (ON+, ON−, and HC). However, BMO-MRW, on the other hand, could not distinguish between ON(−) patients and HC. The relationship between OCT parameters and EDSS were observed only in eyes with an ON history in all three techniques. A meaningful model with 78% accuracy was obtained by using only the OCT parameters as risk factors. In the ROC analysis, no parameters were found to have acceptable high sensitivity and specificity. BMO-MRW was statistically weaker in every aspect than other RNFL techniques. Conclusion: The novel APS-RNFL technique appears to be a bit more reliable alternative to S-RNFL technique to support therapeutic decision-making in MS. BMO-MRW has not been found as a successful alternative to S-RNFL.

Influence of uveitis on Bruch’s membrane opening minimum rim width and retinal nerve fibre layer thickness measurements

2018 ◽  
Vol 103 (10) ◽  
pp. 1413-1417 ◽  
Author(s):  
Matthias F Kriegel ◽  
Arnd Heiligenhaus ◽  
Carsten Heinz
Keyword(s):  
Layer Thickness ◽  
Nerve Fibre ◽  
Retinal Nerve Fibre Layer ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Fibre Layer ◽  
Bruch’S Membrane Opening ◽  
Nerve Fibre Layer ◽  
Active Inflammation ◽  
The Impact

Background/aimsTo assess the impact of papillary leakage and active inflammation on optical coherence tomography (OCT)-based retinal nerve fibre layer thickness (RNFLT) and Bruch’s membrane opening minimum rim width (BMO-MRW) measurements in uveitic eyes with and without secondary glaucoma.MethodsProspective, single-centre analysis of patients with uveitis. All patients included received a fluorescein angiography examination and an OCT scan measuring the BMO-MRW and the RNFLT in three concentric peripapillary ring scans.ResultsOverall, 95 eyes of 56 patients were enrolled. Papillary leakage and active inflammation were present in 39 (41%) and 57 (60%) eyes, respectively. Twenty-one eyes were classified as glaucomatous; 10 of those glaucomatous eyes showed papillary leakage. Both BMO-MRW and RNFLT measurements were significantly increased in eyes with papillary leakage (BMO-MRW: p=0.0001; RNFLT: first to third ring (p<0.0001)). Active inflammation led to a significantly thickened RNFLT (first ring: p=0.0026; second ring: p=0.0009; third ring: p=0.0002) while only a trend towards increased values could be observed in the BMO-MRW measurements (p=0.3063). Glaucomatous eyes with papillary leakage demonstrated significantly higher values on both BMO-MRW and RNFLT measurements than glaucomatous eyes without leakage (BMO-MRW: p=0.0159; RNFLT: first ring: p=0.0062; second ring: p=0.0037; third ring: p=0.0197). No significant difference could be observed between glaucomatous eyes with leakage and non-glaucomatous eyes without leakage (BMO-MRW: p=0.4132; RNFLT: first ring: p=0.5412; second ring: p=0.3208; third ring: p=0.1164).ConclusionsThe OCT scanning parameters BMO-MRW and RNFLT were significantly influenced by papillary leakage in uveitic eyes with and without glaucoma. RNFLT values were also significantly increased while active inflammation was present. In patients with uveitis, these OCT-based imaging tools should be interpreted with caution, especially in those with papillary leakage or active inflammation.

scholarly journals Factors Associated with Increased Neuroretinal Rim Thickness Measured Based on Bruch’s Membrane Opening-Minimum Rim Width after Trabeculectomy

2021 ◽  
Vol 10 (16) ◽  
pp. 3646
Author(s):  
Do-Young Park ◽  
Soon-Cheol Cha
Keyword(s):  
Open Angle Glaucoma ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Fiber Layer ◽  
Factors Associated ◽  
Nerve Fiber Layer Thickness ◽  
Neuroretinal Rim ◽  
Before And After ◽  
Bruch’S Membrane Opening ◽  
Sd Oct

Purpose: To investigate the factors associated with an increase in the neuroretinal rim (NRR) thickness measured based on Bruch’s membrane opening-minimum rim width (BMO-MRW) after trabeculectomy in patients with primary open-angle glaucoma (POAG). Methods: We analyzed the BMO-MRW using spectral-domain optical coherence tomography (SD-OCT) of patients with POAG who underwent a trabeculectomy for uncontrolled intraocular pressure (IOP) despite maximal IOP reduction treatment. The BMO-MRW was measured before and after trabeculectomy in patients with POAG. Demographic and systemic factors, ocular factors, pre- and post-operative IOP, and visual field parameters were collected, together with SD-OCT measurements. A regression analysis was performed to investigate the factors that affected the change in the BMO-MRW after the trabeculectomy. Results: Forty-four eyes of 44 patients were included in the analysis. The IOP significantly decreased from a preoperative 27.0 mmHg to a postoperative 10.5 mmHg. The mean interval between the trabeculectomy and the date of post-operative SD-OCT measurement was 3.3 months. The global and sectoral BMO-MRW significantly increased after trabeculectomy, whereas the peripapillary retinal nerve fiber layer thickness did not show a difference between before and after the trabeculectomy. Younger age and a greater reduction in the IOP after the trabeculectomy were significantly associated with the increase in the BMO-MRW after trabeculectomy. Conclusions: The NRR thickness measured based on the BMO-MRW increased with decreasing IOP after trabeculectomy, and the increase in the BMO-MRW was associated with the young age of the patients and greater reduction in the IOP after trabeculectomy. Biomechanically, these suggest that the NRR comprises cells and substances that sensitively respond to changes in the IOP and age.

The use of recombinant human TSH in the follow-up of differentiated thyroid cancer: experience from a large patient cohort in a single centre

2002 ◽  
Vol 56 (2) ◽  
pp. 247-252 ◽  
Author(s):  
Vitale Giovanni ◽  
Lupoli Gelsy Arianna ◽  
Ciccarelli Antonio ◽  
Fonderico Francesco ◽  
Klain Michele ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
Single Centre ◽  
Patient Cohort ◽  
Large Patient Cohort ◽  
Recombinant Human Tsh ◽  
Large Patient ◽  
Cancer Experience
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