scholarly journals Ganglion cell layer measurements correlate with disease severity in patients with Alzheimer's disease

2016 ◽  
Vol 94 (6) ◽  
pp. e454-e459 ◽  
Author(s):  
Elena Garcia-Martin ◽  
Maria P. Bambo ◽  
Marcia L. Marques ◽  
Maria Satue ◽  
Sofia Otin ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Ganglion Cell ◽  
Disease Severity ◽  
Ganglion Cell Layer ◽  
Cell Layer

scholarly journals Ganglion cell layer thinning in prodromal Alzheimer's disease defined by amyloid PET

2019 ◽  
Vol 5 (1) ◽  
pp. 570-578 ◽  
Author(s):  
Alicia López‐de‐Eguileta ◽  
Carmen Lage ◽  
Sara López‐García ◽  
Ana Pozueta ◽  
María García‐Martínez ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Ganglion Cell ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Amyloid Pet ◽  
Prodromal Alzheimer’S Disease

Decreases in ganglion cell layer and inner plexiform layer volumes correlate better with disease severity in schizophrenia patients than retinal nerve fiber layer thickness: Findings from spectral optic coherence tomography

2016 ◽  
Vol 32 ◽  
pp. 9-15 ◽  
Author(s):  
M. Celik ◽  
A. Kalenderoglu ◽  
A. Sevgi Karadag ◽  
O. Bekir Egilmez ◽  
B. Han-Almis ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Disease Severity ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Plexiform Layer ◽  
Optic Coherence Tomography ◽  
Inner Plexiform Layer ◽  
Fiber Layer ◽  
Rnfl Thickness ◽  
Treatment Refractory

AbstractBackgroundOptic coherence tomography (OCT) is a new, contactless and fast neuroimaging method. Previous studies have observed thinning of the retinal nerve fibre layer (RNFL) in many neurodegenerative diseases, and researchers have suggested that correlations exist between the thinning of the RNFL and the neurodegeneration detected with other imaging methods or the severity of illness. More recently, OCT has been used in patients with schizophrenia. RNFL thinning has also been detected in these patients. With more sophisticated devices, segmentation of the retina and measurements of the ganglion cell layer (GCL) and internal plexiform layer (IPL) can be performed.MethodsWe measured the RNFL thickness and the GCL and IPL volumes in 40 treatment refractory patients with schizophrenia, 41 treatment responsive refractory patients and 41 controls using spectral-OCT, and we evaluated the correlations between the disease severity and OCT measurements.ResultsThe global RNFL thickness and GCL and IPL volumes were decreased in the patients with schizophrenia compared with the controls. In addition, the GCL and IPL volumes were lower in the treatment refractory patients with schizophrenia compared to the treatment responsive patients. Using parameters such as the Positive and Negative Syndrome Scale (PANSS) and Clinical Global Impression (CGI) scores, the disease duration and number of hospitalizations, correlations between the GCL and IPL volumes and disease severity were stronger than the correlations between the RNFL and the disease parameters.ConclusionOur findings suggest that OCT can be used to detect neurodegeneration in schizophrenia and that the GCL and IPL volumes can also be used to monitor the progression of neurodegeneration.

The SCG10-related gene family in the developing rat retina: Persistent expression of SCLIP and stathmin in mature ganglion cell layer

2000 ◽  
Vol 861 (2) ◽  
pp. 399-407 ◽  
Author(s):  
Toru Nakazawa ◽  
Itsuko Nakano ◽  
Tatsuo Furuyama ◽  
Hiroshi Morii ◽  
Makoto Tamai ◽  
...  
Keyword(s):  
Gene Family ◽  
Ganglion Cell ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Related Gene ◽  
Rat Retina ◽  
Developing Rat

scholarly journals Retinal nerve fibre layer, ganglion cell layer and choroid thinning in migraine with aura

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Metin Ekinci ◽  
Erdinç Ceylan ◽  
Halil Hüseyin Çağatay ◽  
Sadullah Keleş ◽  
Nergiz Hüseyinoğlu ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Nerve Fibre ◽  
Migraine With Aura ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Retinal Nerve Fibre Layer ◽  
Fibre Layer ◽  
Nerve Fibre Layer
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