scholarly journals Intra-ocular pressure-lowering effects of a Rho kinase inhibitor, ripasudil (K-115), over 24 hours in primary open-angle glaucoma and ocular hypertension: a randomized, open-label, crossover study

2014 ◽  
Vol 93 (4) ◽  
pp. e254-e260 ◽  
Author(s):  
Hidenobu Tanihara ◽  
Toshihiro Inoue ◽  
Tetsuya Yamamoto ◽  
Yasuaki Kuwayama ◽  
Haruki Abe ◽  
...  
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Kinase Inhibitor ◽  
Open Angle Glaucoma ◽  
Rho Kinase ◽  
Open Angle ◽  
Open Label ◽  
Intra Ocular Pressure ◽  
Rho Kinase Inhibitor ◽  
Pressure Lowering ◽  
Ocular Pressure

Rho kinase inhibitor for primary open-angle glaucoma and ocular hypertension

2020 ◽  
Author(s):  
Josefine Clement Freiberg ◽  
Alexander von Spreckelsen ◽  
Naira Khachatryan ◽  
Miriam Kolko ◽  
Augusto Azuara-Blanco ◽  
...  
Keyword(s):  
Ocular Hypertension ◽  
Primary Open Angle Glaucoma ◽  
Kinase Inhibitor ◽  
Open Angle Glaucoma ◽  
Rho Kinase ◽  
Open Angle ◽  
Rho Kinase Inhibitor

Phase 2 Randomized Clinical Study of a Rho Kinase Inhibitor, K-115, in Primary Open-Angle Glaucoma and Ocular Hypertension

2013 ◽  
Vol 156 (4) ◽  
pp. 731-736.e2 ◽  
Author(s):  
Hidenobu Tanihara ◽  
Toshihiro Inoue ◽  
Tetsuya Yamamoto ◽  
Yasuaki Kuwayama ◽  
Haruki Abe ◽  
...  
Keyword(s):  
Clinical Study ◽  
Ocular Hypertension ◽  
Primary Open Angle Glaucoma ◽  
Kinase Inhibitor ◽  
Open Angle Glaucoma ◽  
Rho Kinase ◽  
Phase 2 ◽  
Open Angle ◽  
Randomized Clinical Study ◽  
Rho Kinase Inhibitor

scholarly journals Physiological Bases of Electric Stimulation as a New Approach to Glaucoma IOP Control

2021 ◽  
Author(s):  
Luis Nino-de-Rivera ◽  
Diego Cervera ◽  
Paola Castillo-Juarez
Keyword(s):  
Electric Stimulation ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Ionic Channels ◽  
Open Angle ◽  
New Approach ◽  
Intra Ocular Pressure ◽  
Voltage Dependent ◽  
Ocular Pressure ◽  
One Year

This Chapter focuses in the electrophysiological bases to support Trans Palpebral Electrical Stimulation TPES as a new alternative to control Intraocular Pressure IOP. Primary open Angle Glaucoma POAG is described in our approach as a dysfunction of the membrane potential of TM cells due to the dysfunction of the Maxi potassium depended Calcium Channels BKCa2+ of the Trabecular Mesh TM. We review through the paper the main contributions about Trabecular mesh dysfunction related with Voltage dependent ionic channels. We also present in this paper new results in controlling intra ocular pressure IOP during one year of trans palpebral Electric stimulation in patients with Primary open-angle glaucoma (POAG).

scholarly journals Twenty-four-hour pattern of intra-ocular pressure in untreated patients with primary open-angle glaucoma

2016 ◽  
Vol 94 (6) ◽  
pp. e460-e467 ◽  
Author(s):  
Jingyi Cheng ◽  
Xiangmei Kong ◽  
Ming Xiao ◽  
Xinghuai Sun
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Intra Ocular Pressure ◽  
Ocular Pressure

scholarly journals Results of Rectangular and Triangular Shaped Scleral Flaps in Trabeculectomy in Terms of Control of Intra Ocular Pressure (IOP) and Complications

2021 ◽  
Vol 37 (4) ◽  
Author(s):  
Qirat Qurban ◽  
Zeeshan Kamil ◽  
Khalid Mahmood
Keyword(s):  
Intraocular Pressure ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Anterior Chamber Depth ◽  
Open Angle ◽  
Scleral Flap ◽  
Intra Ocular Pressure ◽  
Group A ◽  
Ocular Pressure ◽  
Group B

Purpose: To compare between the results of rectangular and triangular shaped scleral flaps in trabeculectomy for primary open angle glaucoma. Study design: Quasi experimental study Place and Duration of Study: Khalid eye clinic, Karachi, from July 2018 to June 2019. Methods: This study included 24 patients of either gender and age from 40 to 65 years. Patients with a diagnosis of primary open angle glaucoma refractory to medical treatment were included by convenient sampling technique. They were divided into two groups. Group A underwent trabeculectomy with rectangular shaped scleral flap whereas Group B underwent trabeculectomy with triangular shaped scleral flap. The main outcome measures were intraocular pressure reduction, anterior chamber depth and post-operative complications. All patients were followed up for a period of two months. Results: Mean age was 52.1± 6.72 years. Mean pre-operative intraocular pressure in group A was 24.4±2.13 mmHg and 23.5±1.64 mmHg in group B. Mean post-operative IOP was 11.6±1.51 mmHg in group A and 13.4±1.67 mmHg in group B with p-value of 0.11. Pre-operative anterior chamber depth (ACD) was grade 4 both groups. It remained same in all patients of group A but two patients of group B changed to grade 3 ACD. Two patients of group B developed hypotony on the first post-operative day. They did not require revision suturing and were managed conservatively. Conclusion: Both types of scleral flap are effective in reducing IOP but rectangular scleral flap reduced IOP more as compared to triangular scleral flap but the difference was not statistically significant. Keywords: Trabeculectomy, Intra ocular pressure, Open angle glaucoma.

Effects of Postural Variation on Intra-ocular Pressure: Comparison between Pseudo-exfoliation Glaucoma and Primary Open Angle Glaucoma

2020 ◽  
Vol 45 (10) ◽  
pp. 1309-1314
Author(s):  
Nimrod Dar ◽  
Avner Belkin ◽  
Shani Pillar ◽  
Vadim Sheiman ◽  
Ortal F. Tempelhof ◽  
...  
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Intra Ocular Pressure ◽  
Exfoliation Glaucoma ◽  
Ocular Pressure
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