scholarly journals Tipless Transseptal Cannula Concept Combines Improved Hemodynamic Properties and Risk‐Reduced Placement: an In Silico Proof‐of‐Concept

2021 ◽  
Author(s):  
Kristin Hugenroth ◽  
Michael Neidlin ◽  
Ulrich M. Engelmann ◽  
Tim A.S. Kaufmann ◽  
Ulrich Steinseifer ◽  
...  
Keyword(s):  
In Silico ◽  
Proof Of Concept

scholarly journals Peptides modulating conformational changes in secreted chaperones: From in silico design to preclinical proof of concept

2009 ◽  
Vol 106 (33) ◽  
pp. 13797-13801 ◽  
Author(s):  
Y. Kliger ◽  
O. Levy ◽  
A. Oren ◽  
H. Ashkenazy ◽  
Z. Tiran ◽  
...  
Keyword(s):  
Conformational Changes ◽  
In Silico ◽  
Proof Of Concept ◽  
In Silico Design

scholarly journals An in silico structural approach to characterize human and rainbow trout estrogenicity of mycotoxins: Proof of concept study using zearalenone and alternariol

2020 ◽  
Vol 312 ◽  
pp. 126088 ◽  
Author(s):  
Luca Dellafiora ◽  
Isabelle P. Oswald ◽  
Jean-Lou Dorne ◽  
Gianni Galaverna ◽  
Paola Battilani ◽  
...  
Keyword(s):  
Rainbow Trout ◽  
In Silico ◽  
Structural Approach ◽  
Proof Of Concept ◽  
Concept Study

In silico drug repositioning on F508del-CFTR: A proof-of-concept study on the AIFA library

2021 ◽  
Vol 213 ◽  
pp. 113186 ◽  
Author(s):  
Alessandro Orro ◽  
Matteo Uggeri ◽  
Marco Rusnati ◽  
Chiara Urbinati ◽  
Nicoletta Pedemonte ◽  
...  
Keyword(s):  
In Silico ◽  
Drug Repositioning ◽  
Proof Of Concept ◽  
Concept Study

scholarly journals Designing Minimal Genomes Using Whole-Cell Models

2018 ◽  
Author(s):  
Joshua Rees ◽  
Oliver Chalkley ◽  
Sophie Landon ◽  
Oliver Purcell ◽  
Lucia Marucci ◽  
...  
Keyword(s):  
In Silico ◽  
Genome Engineering ◽  
Cell Model ◽  
Mycoplasma Genitalium ◽  
Computational Design ◽  
Functional Assay ◽  
Proof Of Concept ◽  
Computational Tools ◽  
Whole Cell ◽  
Genome Design

AbstractIn the future, entire genomes tailored to specific functions and environments could be designed using computational tools. However, computational tools for genome design are currently scarce. Here we present algorithms that enable the use of design-simulate-test cycles for genome design, using genome minimisation as a proof-of-concept. Minimal genomes are ideal for this purpose as they have a simple functional assay, the cell either replicates or not. We used the first (and currently only published) whole-cell model, for the bacterium Mycoplasma genitalium. Our computational design-simulate-test cycles discovered novel in-silico minimal genomes smaller than JCVI-Syn3.0, a bacteria with, currently, the smallest genome that can be grown in pure culture. In the process, we identified 10 low essentiality genes, 18 high essentiality genes, and produced evidence for at least two Mycoplasma genitalium in-silico minimal genomes. This work brings combined computational and laboratory genome engineering a step closer.

Stearylated cycloarginine nanosystems for intracellular delivery – simulations, formulation and proof of concept

RSC Advances ◽  
2016 ◽  
Vol 6 (114) ◽  
pp. 113538-113550 ◽  
Author(s):  
V. Dhawan ◽  
A. Magarkar ◽  
G. Joshi ◽  
D. Makhija ◽  
A. Jain ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
In Silico ◽  
Intracellular Delivery ◽  
Proof Of Concept ◽  
Reduced Toxicity

Novel cationic agent liposomes performed better in silico translating in higher cellular uptake with reduced toxicity.

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