In Vitro Performance Analysis of a Novel Pulsatile Diagonal Pump in a Simulated Pediatric Mechanical Circulatory Support System

2013 ◽  
Vol 38 (1) ◽  
pp. 64-72 ◽  
Author(s):  
Shigang Wang ◽  
Allen R. Kunselman ◽  
Akif Ündar
Keyword(s):  
Performance Analysis ◽  
Support System ◽  
Mechanical Circulatory Support ◽  
Circulatory Support ◽  
In Vitro Performance

Hemolysis associated with Impella heart pump positioning: In vitro hemolysis testing and computational fluid dynamics modeling

2020 ◽  
Vol 43 (11) ◽  
pp. 710-718
Author(s):  
Nicholas Roberts ◽  
Uma Chandrasekaran ◽  
Soumen Das ◽  
Zhongwei Qi ◽  
Scott Corbett
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Mechanical Circulatory Support ◽  
Circulatory Support ◽  
Dynamics Modeling ◽  
Computational Fluid Dynamics Modeling ◽  
Heart Pump ◽  
Mechanical Circulatory Support Devices ◽  
Support Devices

Introduction: Short-term mechanical circulatory support devices provide temporary hemodynamic support in heart failure and are increasingly used to enable recovery or as a bridge to decision. Blood damage with mechanical circulatory support devices is influenced by many factors, including the magnitude and duration of shear stress and obstruction to blood flow. This study aimed to evaluate the effects of the Impella CP® heart pump positioning on hemolysis using in vitro hemolysis testing and computational fluid dynamics modeling. Methods: The in vitro hemolysis testing was conducted per the recommended Food and Drug Administration and American Society for Testing and Materials guidelines. The bench hemolysis testing and computational fluid dynamics simulation analysis were performed for both normal operating (outlet unobstructed) and outlet-obstructed condition of Impella CP (mimicking outlet on the aortic valve due to improper positioning). Results: The modified index of hemolysis was 2.78 ± 0.69 at normal operating conditions compared to 18.7 ± 7.8 when the Impella CP outlet was obstructed ( p = 0.002). Computational fluid dynamics modeling showed about three times increase in exposure time to regions of high shear stress when the Impella CP outlet was obstructed compared to unobstructed condition, thus supporting the experimental observations. Conclusion: Based on these results, it is recommended to ensure proper placement of Impella CP via regular monitoring using echocardiographic guidance or other methods to minimize the risk of hemolysis associated with an obstructed outflow.

scholarly journals Ghost Cells for Mechanical Circulatory Support In Vitro Testing: A Novel Large Volume Production

2020 ◽  
Vol 15 (4) ◽  
pp. 1900239
Author(s):  
Malte Schöps ◽  
Johanna C. Clauser ◽  
Matthias F. Menne ◽  
Dennis Faßbänder ◽  
Thomas Schmitz‐Rode ◽  
...  
Keyword(s):  
Large Volume ◽  
Mechanical Circulatory Support ◽  
Circulatory Support ◽  
In Vitro Testing ◽  
Ghost Cells ◽  
Volume Production

In Vitro Cardiovascular System Emulator (Bioreactor) for the Simulation of Normal and Diseased Conditions With and Without Mechanical Circulatory Support

2013 ◽  
Vol 37 (6) ◽  
pp. 549-560 ◽  
Author(s):  
Paula Ruiz ◽  
Mohammad Amin Rezaienia ◽  
Akbar Rahideh ◽  
Thomas R. Keeble ◽  
Martin T. Rothman ◽  
...  
Keyword(s):  
Cardiovascular System ◽  
Mechanical Circulatory Support ◽  
Circulatory Support

LIFEBRIDGE: A Portable, Modular, Rapidly Available “Plug-and-Play” Mechanical Circulatory Support System

2005 ◽  
Vol 80 (5) ◽  
pp. 1887-1892 ◽  
Author(s):  
Uwe Mehlhorn ◽  
Michael Brieske ◽  
Uwe M. Fischer ◽  
Markus Ferrari ◽  
Patrick Brass ◽  
...  
Keyword(s):  
Support System ◽  
Mechanical Circulatory Support ◽  
Circulatory Support ◽  
Plug And Play

Numerical and In Vitro Investigation of a Novel Mechanical Circulatory Support Device Installed in the Descending Aorta

2015 ◽  
Vol 39 (6) ◽  
pp. 502-513 ◽  
Author(s):  
Mohammad Amin Rezaienia ◽  
Akbar Rahideh ◽  
Borhan Alhosseini Hamedani ◽  
Dawid Emanuel Maximilian Bosak ◽  
Silviya Zustiak ◽  
...  
Keyword(s):  
Mechanical Circulatory Support ◽  
Circulatory Support ◽  
Descending Aorta ◽  
In Vitro Investigation ◽  
Support Device ◽  
Mechanical Circulatory Support Device ◽  
Circulatory Support Device

Long-term mechanical circulatory support system reliability recommendation

1998 ◽  
Vol 66 (5) ◽  
pp. 1852-1859 ◽  
Author(s):  
George M Pantalos ◽  
Frank Altieri ◽  
Alan Berson ◽  
Harvey Borovetz ◽  
Ken Butler ◽  
...  
Keyword(s):  
Support System ◽  
System Reliability ◽  
Mechanical Circulatory Support ◽  
Circulatory Support
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