The Evaluation of Leukocytes in Response to the In Vitro Testing of Ventricular Assist Devices

2013 ◽  
pp. n/a-n/a ◽  
Author(s):  
Chris H.H. Chan ◽  
Andrew Hilton ◽  
Graham Foster ◽  
Karl M. Hawkins ◽  
Nafiseh Badiei ◽  
...  
Keyword(s):  
Ventricular Assist Devices ◽  
In Vitro Testing ◽  
Ventricular Assist ◽  
Assist Devices

COMPUTER MANAGED IN VITRO TESTING OF VENTRICULAR ASSIST DEVICES

ASAIO Journal ◽  
1979 ◽  
Vol 25 (1) ◽  
pp. 192-196
Author(s):  
M. L. Pickard ◽  
W. OʼBaonon ◽  
M. J. Lloyd ◽  
M. E. Debakey
Keyword(s):  
Ventricular Assist Devices ◽  
In Vitro Testing ◽  
Ventricular Assist ◽  
Assist Devices

scholarly journals The CentriMag Centrifugal Blood Pump as a Benchmark for In Vitro Testing of Hemocompatibility in Implantable Ventricular Assist Devices

2014 ◽  
Vol 39 (2) ◽  
pp. 93-101 ◽  
Author(s):  
Chris H.H. Chan ◽  
Ina Laura Pieper ◽  
Rebecca Hambly ◽  
Gemma Radley ◽  
Alyssa Jones ◽  
...  
Keyword(s):  
Ventricular Assist Devices ◽  
Blood Pump ◽  
In Vitro Testing ◽  
Ventricular Assist ◽  
Centrifugal Blood Pump ◽  
Assist Devices

scholarly journals Response of a physiological controller for ventricular assist devices during acute patho-physiological events: an in vitro study

2017 ◽  
Vol 62 (6) ◽  
pp. 623-633 ◽  
Author(s):  
Anastasios Petrou ◽  
Panagiotis Pergantis ◽  
Gregor Ochsner ◽  
Raffael Amacher ◽  
Thomas Krabatsch ◽  
...  
Keyword(s):  
Valsalva Maneuver ◽  
Constant Speed ◽  
Ventricular Assist Devices ◽  
Moving Window ◽  
Clinical Implementation ◽  
Premature Ventricular Contractions ◽  
Ventricular Assist ◽  
Assist Devices ◽  
Mock Circulation

AbstractThe current paper analyzes the performance of a physiological controller for turbodynamic ventricular assist devices (tVADs) during acute patho-physiological events. The numerical model of the human blood circulation implemented on our hybrid mock circulation was extended in order to simulate the Valsalva maneuver (VM) and premature ventricular contractions (PVCs). The performance of an end-diastolic volume (EDV)-based physiological controller for VADs, named preload responsive speed (PRS) controller was evaluated under VM and PVCs. A slow and a fast response of the PRS controller were implemented by using a 3 s moving window, and a beat-to-beat method, respectively, to extract the EDV index. The hemodynamics of a pathological circulation, assisted by a tVAD controlled by the PRS controller were analyzed and compared with a constant speed support case. The results show that the PRS controller prevented suction during the VM with both methods, while with constant speed, this was not the case. On the other hand, the pump flow reduction with the PRS controller led to low aortic pressure, while it remained physiological with the constant speed control. Pump backflow was increased when the moving window was used but it avoided sudden undesirable speed changes, which occurred during PVCs with the beat-to-beat method. In a possible clinical implementation of any physiological controller, the desired performance during frequent clinical acute scenarios should be considered.

Defibrillator-Heart Pump: An Implantable Ventricular Assist Device With Integrated Defibrillator Component—The First In Vitro Testing

2019 ◽  
Vol 26 (6) ◽  
pp. 720-724
Author(s):  
Anas Aboud ◽  
Kai Liebing ◽  
Charlie Abraham ◽  
Jan-Christian Reil ◽  
Yara Turkistani ◽  
...  
Keyword(s):  
Heart Failure ◽  
Therapeutic Option ◽  
Left Ventricular ◽  
Ventricular Assist Devices ◽  
In Vitro Testing ◽  
Left Ventricular Assist Devices ◽  
Ventricular Assist ◽  
Heart Pump ◽  
Increased Risk

Left ventricular assist devices (LVADs) are an important therapeutic option for patients with end-stage heart failure waiting for heart transplantation or in older patients as definite therapy for heart failure. Interestingly, about 62% of patients receiving LVADs do not have an automatic implantable cardioverter-defibrillator (AICD) at the time of implantation, although these patients have increased risk of being confronted with dangerous arrhythmia. Therefore, an LVAD system including AICD function is a reasonable alternative for such heart failure patients thereby avoiding a second surgical intervention for AICD implantation. In this article, a newly developed system including LVAD and AICD function is introduced, and we also report its first in vitro testing.

Efficacy of Combination of N-acetylcysteine, Gentamicin, and Amphotericin B for Prevention of Microbial Colonization of Ventricular Assist Devices

2009 ◽  
Vol 30 (2) ◽  
pp. 190-192 ◽  
Author(s):  
Maria D. Hernandez ◽  
Mohammad D. Mansouri ◽  
Saima Aslam ◽  
Barry Zeluff ◽  
Rabih O. Darouiche
Keyword(s):  
Antimicrobial Activity ◽  
Amphotericin B ◽  
Rabbit Model ◽  
Microbial Colonization ◽  
Ventricular Assist Devices ◽  
Ventricular Assist ◽  
In Vivo Efficacy ◽  
Assist Devices

We assessed the in vitro antimicrobial activity and the in vivo efficacy of dipping ventricular assist devices in a combination of N-acetylcysteine, gentamicin, and amphotericin B (NAC/G/A). Ventricular assist devices dipped in NAC/G/A exhibited broad-spectrum antimicrobial activity in vitro and were less likely than undipped devices to become colonized with Staphylococcus aureus in a rabbit model.

Hydrodynamic response of a VAD with a compliant cannula: results of in vitro tests

1994 ◽  
Vol 17 (12) ◽  
pp. 635-642 ◽  
Author(s):  
J.C. Antoranz ◽  
J.F. Del Cañizo ◽  
M.M. Desco
Keyword(s):  
The Other ◽  
Hydrodynamic Performance ◽  
Ventricular Assist Devices ◽  
In Vitro Tests ◽  
Ventricular Assist ◽  
Assist Devices ◽  
Hydrodynamic Response

We report on comparative in vitro tests of two ventricular assist devices (VAD) one with a rigid input cannula and the other with a collapsible (compliant) inlet cannula. We show how this compliant cannula yields significant improvements in the hydrodynamic performance of the system.

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