Ileal Dieulafoy's lesion as a rare cause of lower gastrointestinal bleeding associated with inflammatory bowel disease

2021 ◽  
Vol 91 (5) ◽  
pp. 1042-1043
Author(s):  
Carlos Garcia‐Sanchez ◽  
Jose Pintor‐Tortolero ◽  
Fernando Portilla
Keyword(s):  
Inflammatory Bowel Disease ◽  
Gastrointestinal Bleeding ◽  
Bowel Disease ◽  
Lower Gastrointestinal Bleeding ◽  
Dieulafoy’S Lesion ◽  
Inflammatory Bowel

Rectal Bleeding in Prader-Willi Syndrome

PEDIATRICS ◽  
1996 ◽  
Vol 97 (2) ◽  
pp. 265-267
Author(s):  
SANGEETA A. BHARGAVA ◽  
PHILIP E. PUTNAM ◽  
SAMUEL A. KOCOSHIS ◽  
MARC ROWE ◽  
JEANNE M. HANCHETT
Keyword(s):  
Inflammatory Bowel Disease ◽  
Gastrointestinal Bleeding ◽  
Rectal Bleeding ◽  
Bowel Disease ◽  
Lower Gastrointestinal Bleeding ◽  
Prader Willi Syndrome ◽  
Anorectal Disease ◽  
Skin Picking ◽  
Inflammatory Bowel

Individuals with Prader-Willi syndrome manifest severe skin picking behavior. We report three patients with this syndrome in whom an extension of this behavior to rectal picking resulted in significant lower gastrointestinal bleeding and anorectal disease. The recognition of this behavior is important to avoid misdiagnosing inflammatory bowel disease in this group of patients.

scholarly journals Streptococcus thermophilus NCIMB 41856 ameliorates signs of colitis in an animal model of inflammatory bowel disease

2017 ◽  
Vol 8 (4) ◽  
pp. 605-614 ◽  
Author(s):  
J.R. Bailey ◽  
V. Vince ◽  
N.A. Williams ◽  
T.A. Cogan
Keyword(s):  
Inflammatory Bowel Disease ◽  
Gastrointestinal Bleeding ◽  
Bacterial Translocation ◽  
Bowel Disease ◽  
Clinical Signs ◽  
Streptococcus Thermophilus ◽  
Mucosal Barrier ◽  
Bodyweight Loss ◽  
Mucosal Barrier Function ◽  
Inflammatory Bowel

Treatment of inflammatory bowel disease (IBD) is mainly based on suppression of symptoms, often with numerous side effects. Trials of probiotics in IBD have frequently produced disappointing results. The majority of probiotics are unusual, since they do not require iron for growth, unlike many bacteria resident in the intestine. The IBD intestine is iron-rich due to bleeding and use of oral iron supplements; conventional probiotics would be rapidly outcompeted. We have evaluated an iron-responsive Streptococcus thermophilus strain for its potential to reduce signs of colitis. Efficacy of S. thermophilus was evaluated in the dextran sodium sulphate mouse model of colitis. Treated animals were given 1×108 cfu S. thermophilus per day and clinical observations were taken daily. At termination, gross and histopathological signs of disease, cellular infiltration, location of bacteria, and cytokine expression in the intestine were determined. S. thermophilus delayed onset of colitis and reduced clinical signs of disease, including bodyweight loss and gastrointestinal bleeding. It reduced bacterial translocation into the colonic tissue. Increased numbers of CD8+ intraepithelial lymphocytes were seen in control animals treated with S. thermophilus. S. thermophilus had no effect on gross pathology, histopathology or cytokine production in either colitic or control animals. We propose that S. thermophilus promotes maintenance of mucosal barrier function which reduces bacterial translocation, thereby reducing immune stimulation and associated inflammation. This allows mucosal healing, reducing gastrointestinal bleeding and weight loss. This could be studied as a locally-acting adjunct or alternative to current IBD treatments.

scholarly journals Unusual Cause of Gastrointestinal Bleeding in a Patient with Turner Syndrome

2018 ◽  
Vol 12 (2) ◽  
pp. 292-296 ◽  
Author(s):  
Rafael Bergesch D’Incao ◽  
Marcelo Campos Appel-da-Silva ◽  
Patricia dos Santos Marcon ◽  
Eduardo Marques Correa ◽  
Euler Manenti ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Gastrointestinal Bleeding ◽  
Short Stature ◽  
Turner Syndrome ◽  
X Chromosome ◽  
Bowel Disease ◽  
Genetic Disease ◽  
Gonadal Dysgenesis ◽  
Vascular Lesions ◽  
Inflammatory Bowel

Turner syndrome is an exclusively female genetic disease caused by complete or partial absence of the second X chromosome. It is classically characterized by congenital lymphedema, short stature, and gonadal dysgenesis. In addition, the syndrome is associated with several other abnormalities. One of them is gastrointestinal bleeding, which is frequently associated with inflammatory bowel disease, but it can also be caused by vascular lesions such as hemangioma, vascular ectasia, and telangiectasia. We report the case of a patient with Turner syndrome with an episode of gastrointestinal bleeding, outlining our pathway for the investigation and treatment of this condition.

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