Lumbar artificial intervertebral disc replacement: a systematic review

2013 ◽  
Vol 84 (3) ◽  
pp. 121-127 ◽  
Author(s):  
Prema Thavaneswaran ◽  
Meegan Vandepeer
Keyword(s):  
Systematic Review ◽  
Intervertebral Disc ◽  
Disc Replacement ◽  
Artificial Intervertebral Disc

Lumbar intervertebral disc replacement using bioabsorbable self-reinforced poly-L-lactide full-threaded screws, or cylindrical implants of polylactide polymers, bioactive glass and Polyactive™

2003 ◽  
Vol 16 (03) ◽  
pp. 138-144 ◽  
Author(s):  
P. Ylinen ◽  
R.-M. Tulamo ◽  
M. Kellomäki ◽  
P. Türmälä ◽  
P. Rokkanen ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Intervertebral Discs ◽  
Growing Pigs ◽  
Disc Replacement ◽  
Intervertebral Space ◽  
Lumbar Intervertebral Disc ◽  
Histological Changes ◽  
Preliminary Study ◽  
Artificial Intervertebral Disc

SummaryIntervertebral disc surgery leads to changes in the segmental anatomy and mobility, and subsequently to degenerative changes in the lumbar spine. Artificial intervertebral disc implants sufficient to replace the human lumbar intervertebral disc have been developed and the requirements for these defined. This is to our knowledge the first study on bioabsorbable intervertebral disc replacement implants. SR-PLLA screws, previously used in orthopaedic internal fixations, and cylindrical implants, specifially developed for this experimental preliminary study, were used to replace lumbar intervertebral discs of growing pigs. After a 15-week follow-up period, the radiological and histological changes in the intervertebral spaces were analyzed. The cylindrical implants were able to prevent narrowing of discectomied spaces, and tissue regeneration in the intervertebral space was induced and occured simultaneously with degradation of the implant.

Artificial Intervertebral Disc Replacement Using Bioactive Three-Dimensional Fabric

Spine ◽  
2002 ◽  
Vol 27 (9) ◽  
pp. 929-935 ◽  
Author(s):  
Yoshihisa Kotani ◽  
Kuniyoshi Abumi ◽  
Yasuo Shikinami ◽  
Takashige Takada ◽  
Ken Kadoya ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Three Dimensional ◽  
Disc Replacement ◽  
Artificial Intervertebral Disc

scholarly journals Intervertebral disc therapies for non-specific chronic low back pain: a systematic review and meta-analysis

2021 ◽  
Vol 13 ◽  
pp. 1759720X2110280
Author(s):  
Camille Daste ◽  
Stéphanie Laclau ◽  
Margaux Boisson ◽  
François Segretin ◽  
Antoine Feydy ◽  
...  
Keyword(s):  
Systematic Review ◽  
Low Back Pain ◽  
Back Pain ◽  
Intervertebral Disc ◽  
Chronic Low Back Pain ◽  
Meta Analysis ◽  
Activity Limitations ◽  
Low Back ◽  
Short Term

Objectives: We aim to evaluate the benefits and harms of intervertebral disc therapies (IDTs) in people with non-specific chronic low back pain (NScLBP). Methods: We conducted a systematic review and meta-analysis of randomized trials of IDTs versus placebo interventions, active comparators or usual care. EMBASE, MEDLINE, CENTRAL and CINHAL databases and conference abstracts were searched from inception to June 2020. Two independent investigators extracted data. The primary outcome was LBP intensity at short term (1 week–3 months), intermediate term (3–6 months) and long term (after 6 months). Results: Of 18 eligible trials (among 1396 citations), five assessed glucocorticoids (GCs) IDTs and were included in a quantitative synthesis; 13 assessed other products including etanercept ( n = 2), tocilizumab ( n = 1), methylene blue ( n = 2), ozone ( n = 2), chymopapaine ( n = 1), glycerol ( n = 1), stem cells ( n = 1), platelet-rich plasma ( n = 1) and recombinant human growth and differentiation factor-5 ( n = 2), and were included in a narrative synthesis. Standardized mean differences (95% CI) for GC IDTs for LBP intensity and activity limitations were −1.33 (−2.34; −0.32) and −0.76 (−1.85; 0.34) at short term, −2.22 (−5.34; 0.90) and −1.60 (−3.51; 0.32) at intermediate term and −1.11 (−2.91; 0.70) and −0.63 (−1.68; 0.42) at long term, respectively. Odds ratios (95% CI) for serious and minor adverse events with GC IDTs were 1.09 (0.25; 4.65) and 0.97 (0.49; 1.91). Conclusion: GC IDTs are associated with a reduction in LBP intensity at short term in people with NScLBP. Positive effects are not sustained. IDTs have no effect on activity limitations. Our conclusions are limited by high heterogeneity and a limited methodological quality across studies. Registration PROSPERO: CRD42019106336.

In-situ photopolymerized and monitored implants: successful application to an intervertebral disc replacement

2016 ◽  
Author(s):  
Andreas M. Schmocker ◽  
Azadeh Khoushabi ◽  
Pierre-Etienne Bourban ◽  
Constantin Schizas ◽  
Dominique Pioletti ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Disc Replacement
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