In-situ photopolymerized and monitored implants: successful application to an intervertebral disc replacement

2016 ◽  
Author(s):  
Andreas M. Schmocker ◽  
Azadeh Khoushabi ◽  
Pierre-Etienne Bourban ◽  
Constantin Schizas ◽  
Dominique Pioletti ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Disc Replacement

scholarly journals Injectable and Gellable Chitosan Formulations Filled with Cellulose Nanofibers for Intervertebral Disc Tissue Engineering

Polymers ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1202 ◽  
Author(s):  
Ingo Doench ◽  
Maria Torres-Ramos ◽  
Alexandra Montembault ◽  
Paula Nunes de Oliveira ◽  
Celia Halimi ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Rheological Behavior ◽  
Biomedical Application ◽  
Flow Behavior ◽  
Cellulose Nanofibers ◽  
Nanofibrillated Cellulose ◽  
The Body ◽  
Mechanical Reinforcement ◽  
Invasive Approach

The development of non-cellularized injectable suspensions of viscous chitosan (CHI) solutions (1.7–3.3% (w/w)), filled with cellulose nanofibers (CNF) (0.02–0.6% (w/w)) of the type nanofibrillated cellulose, was proposed for viscosupplementation of the intervertebral disc nucleus pulposus tissue. The achievement of CNF/CHI formulations which can gel in situ at the disc injection site constitutes a minimally-invasive approach to restore damaged/degenerated discs. We studied physico-chemical aspects of the sol and gel states of the CNF/CHI formulations, including the rheological behavior in relation to injectability (sol state) and fiber mechanical reinforcement (gel state). CNF-CHI interactions could be evidenced by a double flow behavior due to the relaxation of the CHI polymer chains and those interacting with the CNFs. At high shear rates resembling the injection conditions with needles commonly used in surgical treatments, both the reference CHI viscous solutions and those filled with CNFs exhibited similar rheological behavior. The neutralization of the flowing and weakly acidic CNF/CHI suspensions yielded composite hydrogels in which the nanofibers reinforced the CHI matrix. We performed evaluations in relation to the biomedical application, such as the effect of the intradiscal injection of the CNF/CHI formulation in pig and rabbit spine models on disc biomechanics. We showed that the injectable formulations became hydrogels in situ after intradiscal gelation, due to CHI neutralization occurring in contact with the body fluids. No leakage of the injectate through the injection canal was observed and the gelled formulation restored the disc height and loss of mechanical properties, which is commonly related to disc degeneration.

Effect of intervertebral disc height on postoperative motion and clinical outcomes after Prodisc-C cervical disc replacement

2009 ◽  
Vol 9 (7) ◽  
pp. 551-555 ◽  
Author(s):  
Chan W.B. Peng ◽  
Martin Quirnoa ◽  
John A. Bendo ◽  
Jeffrey M. Spivak ◽  
Jeffrey A. Goldstein
Keyword(s):  
Intervertebral Disc ◽  
Clinical Outcomes ◽  
Disc Height ◽  
Disc Replacement ◽  
Cervical Disc ◽  
Cervical Disc Replacement ◽  
Intervertebral Disc Height

Intervertebral Disc Replacement Maintains Cervical Spine Kinetics

Spine ◽  
2004 ◽  
Vol 29 (24) ◽  
pp. 2809-2814 ◽  
Author(s):  
Christian M. Puttlitz ◽  
Marc Antoine Rousseau ◽  
Zheng Xu ◽  
Serena Hu ◽  
Bobby K-B Tay ◽  
...  
Keyword(s):  
Cervical Spine ◽  
Intervertebral Disc ◽  
Disc Replacement

The Micromechanical Environment of Intervertebral Disc Cells: Effect of Matrix Anisotropy and Cell Geometry Predicted by a Linear Model

2000 ◽  
Vol 122 (3) ◽  
pp. 245-251 ◽  
Author(s):  
Anthony E. Baer ◽  
Lori A. Setton
Keyword(s):  
Intervertebral Disc ◽  
Mechanical Loading ◽  
Cell Morphology ◽  
Transversely Isotropic ◽  
Tensile Loading ◽  
Cell Geometry ◽  
Mechanical Environment ◽  
The Matrix ◽  
Disc Cells

Cells of the intervertebral disc exhibit spatial variations in phenotype and morphology that may be related to differences in their local mechanical environments. In this study, the stresses, strains, and dilatations in and around cells of the intervertebral disc were studied with an analytical model of the cell as a mechanical inclusion embedded in a transversely isotropic matrix. In response to tensile loading of the matrix, the local mechanical environment of the cell differed among the anatomic regions of the disc and was strongly influenced by changes in both matrix anisotropy and parameters of cell geometry. The results of this study suggest that the local cellular mechanical environment may play a role in determining both cell morphology in situ and the inhomogeneous response to mechanical loading observed in cells of the disc. [S0148-0731(00)00603-8]

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