scholarly journals The Swedish MS registry – clinical support tool and scientific resource

2015 ◽  
Vol 132 (S199) ◽  
pp. 11-19 ◽  
Author(s):  
J. Hillert ◽  
L. Stawiarz
2018 ◽  
Vol 15 (8) ◽  
pp. 513-515 ◽  
Author(s):  
Maryam Alsharqi ◽  
Ross Upton ◽  
Angela Mumith ◽  
Paul Leeson

2006 ◽  
Vol 14 (7S_Part_10) ◽  
pp. P556-P557
Author(s):  
Tau Ming Liew ◽  
Bee Choo Tai ◽  
Philip Yap ◽  
Gerald Choon-Huat Koh

Children ◽  
2018 ◽  
Vol 5 (12) ◽  
pp. 170 ◽  
Author(s):  
Ramzi G. Salloum ◽  
Ryan P. Theis ◽  
Lori Pbert ◽  
Matthew J. Gurka ◽  
Maribeth Porter ◽  
...  

Following guideline recommendations to promote tobacco prevention in adolescent primary care, we developed a patient-facing clinical support tool. The electronic tool screens patients for use and susceptibility to conventional and alternative tobacco products, and promotes patient–provider communication. The purpose of this paper is to describe the iterative stakeholder engagement process used in the development of the tool. During the pre-testing phase, we consulted with scientists, methodologists, clinicians, and Citizen Scientists. Throughout the development phase, we engaged providers from three clinics in focus groups. Usability testing was conducted via in-depth, cognitive interviewing of adolescent patients. Citizen Scientists (n = 7) played a critical role in the final selection of educational content and interviewer training by participating in mock-up patient interviews. Cognitive interviews with patients (n = 16) ensured that systems were in place for the feasibility trial and assessed ease of navigation. Focus group participants (n = 24) offered recommendations for integrating the tool into clinical workflow and input on acceptability and appropriateness, and anticipated barriers and facilitators for adoption and feasibility. Engaging key stakeholders to discuss implementation outcomes throughout the implementation process can improve the quality, applicability, and relevance of the research, and enhance implementation success.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Rainer Thell ◽  
Jascha Zimmermann ◽  
Marton Szell ◽  
Sabine Tomez ◽  
Philip Eisenburger ◽  
...  

AbstractStandard blood laboratory parameters may have diagnostic potential, if polymerase-chain-reaction (PCR) tests are not available on time. We evaluated standard blood laboratory parameters of 655 COVID-19 patients suspected to be infected with SARS-CoV-2, who underwent PCR testing in one of five hospitals in Vienna, Austria. We compared laboratory parameters, clinical characteristics, and outcomes between positive and negative PCR-tested patients and evaluated the ability of those parameters to distinguish between groups. Of the 590 patients (20–100 years, 276 females and 314 males), 208 were PCR-positive. Positive compared to negative PCR-tested patients had significantly lower levels of leukocytes, neutrophils, basophils, eosinophils, lymphocytes, neutrophil-to-lymphocyte ratio, monocytes, and thrombocytes; while significantly higher levels were detected with erythrocytes, hemoglobin, hematocrit, C-reactive-protein, ferritin, activated-partial-thromboplastin-time, alanine-aminotransferase, aspartate-aminotransferase, lipase, creatine-kinase, and lactate-dehydrogenase. From all blood parameters, eosinophils, ferritin, leukocytes, and erythrocytes showed the highest ability to distinguish between COVID-19 positive and negative patients (area-under-curve, AUC: 72.3–79.4%). The AUC of our model was 0.915 (95% confidence intervals, 0.876–0.955). Leukopenia, eosinopenia, elevated erythrocytes, and hemoglobin were among the strongest markers regarding accuracy, sensitivity, specificity, positive and negative predictive value, positive and negative likelihood ratio, and post-test probabilities. Our findings suggest that especially leukopenia, eosinopenia, and elevated hemoglobin are helpful to distinguish between COVID-19 positive and negative tested patients.


2020 ◽  
Author(s):  
Rainer Thell ◽  
Jascha Zimmermann ◽  
Marton Szell ◽  
Sabine Tomez ◽  
Philip Eisenburger ◽  
...  

Abstract Standard blood laboratory parameters may have diagnostic potential, if polymerase-chain-reaction (PCR) tests are not available on time. We evaluated standard blood laboratory parameters of 655 COVID-19 patients suspected to be infected with SARS-CoV-2, who underwent PCR testing in one of five hospitals in Vienna, Austria. We compared laboratory parameters, clinical characteristics, and outcomes between positive and negative PCR-tested patients and evaluated the ability of those parameters to distinguish between groups. Of the 590 patients (20-100years, 276 females and 314 males), 208 were PCR-positive. Positive compared to negative PCR-tested patients had significantly lower levels of leukocytes, neutrophils, basophils, eosinophils, lymphocytes, neutrophil-to-lymphocyte ratio, monocytes, and thrombocytes; while significantly higher levels were detected with erythrocytes, hemoglobin, hematocrit, C-reactive-protein, ferritin, activated-partial-thromboplastin-time, alanine-aminotransferase, aspartate-aminotransferase, lipase, creatine-kinase, and lactate-dehydrogenase. From all blood parameters, eosinophils, ferritin, leukocytes, and erythrocytes showed the highest ability to distinguish between COVID-19 positive and negative patients (area-under-curve: 72.3-79.4%). Leukopenia, eosinopenia, elevated erythrocytes, and hemoglobin were among the strongest markers regarding accuracy, sensitivity, specificity, positive and negative predictive value, positive and negative likelihood ratio, and post-test probabilities. Our findings suggest that especially leukopenia, eosinopenia, as well as elevated erythrocytes, hemoglobin, and ferritin are helpful to distinguish between COVID-19 positive and negative tested patients.


10.2196/12406 ◽  
2019 ◽  
Vol 3 (2) ◽  
pp. e12406
Author(s):  
Ryan P Theis ◽  
Ali M Malik ◽  
Lindsay A Thompson ◽  
Elizabeth A Shenkman ◽  
Lori Pbert ◽  
...  

2013 ◽  
Vol 178 (9) ◽  
pp. 981-985 ◽  
Author(s):  
Kenneth L. Wilson ◽  
Jayfus T. Doswell ◽  
Olatokunbo S. Fashola ◽  
Wayne Debeatham ◽  
Nii Darko ◽  
...  

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