scholarly journals A quantitative global proteomics approach to understanding the functional pathways dysregulated in the spermatozoa of asthenozoospermic testicular cancer patients

Andrology ◽  
2019 ◽  
Author(s):  
M. K. Panner Selvam ◽  
A. Agarwal ◽  
P. N. Pushparaj
Keyword(s):  
Testicular Cancer ◽  
Cancer Patients ◽  
Proteomics Approach ◽  
Functional Pathways

scholarly journals Distinct composition and metabolic functions of human gut microbiota are associated with cachexia in lung cancer patients

2021 ◽  
Author(s):  
Yueqiong Ni ◽  
Zoltan Lohinai ◽  
Yoshitaro Heshiki ◽  
Balazs Dome ◽  
Judit Moldvay ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Gut Microbiota ◽  
Cancer Patients ◽  
Gut Microbiome ◽  
Human Gut ◽  
Microbial Composition ◽  
Shotgun Metagenomics ◽  
Lung Cancer Patients ◽  
Microbial Species ◽  
Functional Pathways

AbstractCachexia is associated with decreased survival in cancer patients and has a prevalence of up to 80%. The etiology of cachexia is poorly understood, and limited treatment options exist. Here, we investigated the role of the human gut microbiome in cachexia by integrating shotgun metagenomics and plasma metabolomics of 31 lung cancer patients. The cachexia group showed significant differences in the gut microbial composition, functional pathways of the metagenome, and the related plasma metabolites compared to non-cachectic patients. Branched-chain amino acids (BCAAs), methylhistamine, and vitamins were significantly depleted in the plasma of cachexia patients, which was also reflected in the depletion of relevant gut microbiota functional pathways. The enrichment of BCAAs and 3-oxocholic acid in non-cachectic patients were positively correlated with gut microbial species Prevotella copri and Lactobacillus gasseri, respectively. Furthermore, the gut microbiota capacity for lipopolysaccharides biosynthesis was significantly enriched in cachectic patients. The involvement of the gut microbiome in cachexia was further observed in a high-performance machine learning model using solely gut microbial features. Our study demonstrates the links between cachectic host metabolism and specific gut microbial species and functions in a clinical setting, suggesting that the gut microbiota could have an influence on cachexia with possible therapeutic applications.

DNA Flow Cytometry in Sperm Cells from Testicular Cancer Patients

1991 ◽  
Vol 19 (2) ◽  
pp. 125-131 ◽  
Author(s):  
S.D. Fosså ◽  
J.E. Melvik ◽  
N.O. Juul ◽  
E.O. Pettersen ◽  
Ø. Åmellem ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Testicular Cancer ◽  
Cancer Patients ◽  
Dna Flow Cytometry ◽  
Sperm Cells

scholarly journals Effect of chemo- or radiotherapy on sperm parameters of testicular cancer patients

2006 ◽  
Vol 21 (11) ◽  
pp. 2882-2889 ◽  
Author(s):  
Loredana Gandini ◽  
Paolo Sgrò ◽  
Francesco Lombardo ◽  
Donatella Paoli ◽  
Franco Culasso ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Cancer Patients ◽  
Sperm Parameters

Analysis of human sperm karyotypes in testicular cancer patients before and after chemotherapy

1997 ◽  
Vol 78 (2) ◽  
pp. 120-123 ◽  
Author(s):  
R.H. Martin ◽  
S. Ernst ◽  
A. Rademaker ◽  
L. Barclay ◽  
E. Ko ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Cancer Patients ◽  
Human Sperm ◽  
Before And After

scholarly journals Comprehensive profiles and diagnostic value of menopausal-specific gut microbiota in premenopausal breast cancer

2021 ◽  
Author(s):  
Ming-Feng Hou ◽  
Fu Ou-Yang ◽  
Chung-Liang Li ◽  
Fang-Ming Chen ◽  
Chieh-Han Chuang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gut Microbiota ◽  
Cancer Patients ◽  
Critical Role ◽  
Postmenopausal Breast Cancer ◽  
Diagnostic Value ◽  
Breast Cancer Patients ◽  
Premenopausal Breast Cancer ◽  
Α Diversity ◽  
Functional Pathways

AbstractIn Western countries, breast cancer tends to occur in older postmenopausal women. However, in Asian countries, the proportion of younger premenopausal breast cancer patients is increasing. Increasing evidence suggests that the gut microbiota plays a critical role in breast cancer. However, studies on the gut microbiota in the context of breast cancer have mainly focused on postmenopausal breast cancer. Little is known about the gut microbiota in the context of premenopausal breast cancer. This study aimed to comprehensively explore the gut microbial profiles, diagnostic value, and functional pathways in premenopausal breast cancer patients. Here, we analyzed 267 breast cancer patients with different menopausal statuses and age-matched female controls. The α-diversity was significantly reduced in premenopausal breast cancer patients, and the β-diversity differed significantly between breast cancer patients and controls. By performing multiple analyses and classification, 14 microbial markers were identified in the different menopausal statuses of breast cancer. Bacteroides fragilis was specifically found in young women of premenopausal statuses and Klebsiella pneumoniae in older women of postmenopausal statuses. In addition, menopausal-specific microbial markers could exhibit excellent discriminatory ability in distinguishing breast cancer patients from controls. Finally, the functional pathways differed between breast cancer patients and controls. Our findings provide the first evidence that the gut microbiota in premenopausal breast cancer patients differs from that in postmenopausal breast cancer patients and shed light on menopausal-specific microbial markers for diagnosis and investigation, ultimately providing a noninvasive approach for breast cancer detection and a novel strategy for preventing premenopausal breast cancer.

scholarly journals MP40-16 CAN CLOMIPHENE CITRATE BE USED TO TREAT HYPOGONADISM IN TESTICULAR CANCER PATIENTS FOLLOWING CHEMOTHERAPY?

2021 ◽  
Vol 206 (Supplement 3) ◽  
Author(s):  
Aisha Siebert ◽  
Jake Miller ◽  
Evan Panken ◽  
Gregory Auffenberg ◽  
Richard Fantus ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Cancer Patients ◽  
Clomiphene Citrate

Insurance Status as a Prognostic Factor for Stage and Survival of Testicular Cancer Patients in Illinois

1994 ◽  
pp. 223-233
Author(s):  
Nicholas J. Vogelzang ◽  
Amy M. Fremgen ◽  
Patrick D. Guinan ◽  
Joan S. Chmiel ◽  
JoAnne L. Sylvester ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Testicular Cancer ◽  
Cancer Patients ◽  
Insurance Status
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