Ameliorative effects of a curcumin vitamin E nanocomposite coated with olive oil against cadmium chloride–induced testicular damage

Andrologia ◽  
2021 ◽  
Author(s):  
Entsar R. Abd‐Allah ◽  
Heba Ali Abd El‐Rahman
Keyword(s):  
Vitamin E ◽  
Olive Oil ◽  
Cadmium Chloride ◽  
Testicular Damage

scholarly journals Modulatory Role of Vitamin E on Proton Pump (ATPase) Activity of Cadmium Chloride-Induced Testicular Damage in Wistar Rats

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Olugbemi T. Olaniyan ◽  
Abdulfatai O. Ojewale ◽  
Olugbenga O. Eweoya ◽  
Adetola A. Adedoyin ◽  
Olamide A. Adesanya ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Single Dose ◽  
Vitamin E ◽  
Proton Pump ◽  
Cadmium Chloride ◽  
Wistar Rats ◽  
Sperm Count ◽  
Testicular Damage ◽  
Pump Activity

Proton pumps are membrane-bound enzymes important in generating gradients that help in maintaining cellular ion homeostasis, cell membrane potential, water, and solute transport across the cell surface. This study investigated the modulatory role of vitamin E on proton pump activity and reproductive parameters in cadmium-induced testicular damage. Twenty (20) male Wistar rats weighing between 180 and 200 g were sorted into 4 groups of five rats each. Group I served as the control and was given normal saline orally, Group II rats were treated with a single dose of 2 mg/kg BW cadmium chloride (CdCl2) intraperitoneally, Group III rats were given 100 mg/kg BW of vitamin E orally, and Group IV rats were given 100 mg/kg BW of vitamin E orally for 30 days prior to intraperitoneal administration of single dose of 2 mg/kg BW of cadmium chloride. The rats were anaesthetized with diethyl ether, and blood samples were obtained for sex hormonal analysis; caudal epididymis was dissected for sperm count, motility, and viability, and the testis were homogenized for lipid peroxidation and proton pump (Na+/K+ ATPase, Ca2+ ATPase, and Mg2+ ATPase) activity. Proton pump activity was assayed spectrophotometrically using the Stewart method to determine the inorganic phosphate level. Histopathological changes of the testis were also studied. The group treated with CdCl2 showed a significant ( p < 0.05 ) decrease in proton pump activity, sperm count, and motility and a significant ( p < 0.05 ) increase in malondialdehyde level when compared with the control group. The CdCl2-treated group also showed decrease reproductive organ weights and hormonal levels and cause necrosis of spermatogonia lining the seminiferous tubules. Rats treated with vitamin E orally for 30 days prior to CdCl2 exposure showed improvement in proton pump activity, a significant ( p < 0.05 ) increase in sperm parameters and luteinizing hormonal level, and a decrease in the lipid peroxidation level as compared with the CdCl2 group. This study showed that vitamin E ameliorated the toxic effect of CdCl2 on proton pump activity in the testes, hence improving testicular integrity, structures, and functions.

Aqueous extract of Adansonia digitata prevents Cadmium Chloride-induced testicular damage in Wistar Rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Babatunde Joseph Dare ◽  
Olugbemi Tope Olaniyan ◽  
Oluwafemi Isaac Oyeniyi ◽  
Gloria Enevwo Okotie ◽  
Ismail Adetayo Lawal ◽  
...  
Keyword(s):  
Single Dose ◽  
Vitamin E ◽  
Aqueous Extract ◽  
Cadmium Chloride ◽  
Wistar Rats ◽  
Antioxidant Activities ◽  
Sucrose Solution ◽  
Saline Group ◽  
Testicular Damage ◽  
Adansonia Digitata

Abstract Objectives The role of aqueous extract of Adansonia digitata was investigated against cadmium chloride-induced testicular damage in Wistar Rats. Methods Thirty (30) male Wistar Rats weighing (150–170) were divided into six groups (n=5). Group A served as control and received oral administration of phosphate buffer saline; group B received 800 mg/kg A. digitata only; group C were injected intraperitoneally with single dose 2 mg/kg b.w cadmium chloride; group D were injected intraperitoneally with single dose 2 mg/kg b.w cadmium chloride and treated with 800 mg/kg aqueous extract of A. digitata; group E received 300 mg/kg vitamin E only; group F were injected intraperitoneally with single dose 2 mg/kg b.w cadmium chloride and treated with 300 mg/kg vitamin E. After 21 days, the animals were sacrificed by cervical dislocation, the testes were excised fixed in Bouins fluids for histological analysis and the other homogenized in 5% sucrose solution for determination of tissue malondialdehyde (MDA) and antioxidant enzyme activity, biochemical assay. Results The group treated with cadmium chloride plus A. digitata caused significant decrease in MDA levels with significant increase (p<0.05) in antioxidant activities and biochemical enzymes when compared to cadmium chloride only group. Conclusions Aqueous extract of A. digitata appears to have ameliorative effect against cadmium chloride-induced testicular damage. This could be attributed to the presence of polyphenolic compound.

Effects of pulsed ultrasound and ultraviolet radiation on Vitamin E and olive oil

1994 ◽  
Vol 102 ◽  
pp. 265-268
Author(s):  
M. Muzzoli ◽  
M. C. Chicca ◽  
S. Pinamonti
Keyword(s):  
Vitamin E ◽  
Ultraviolet Radiation ◽  
Olive Oil ◽  
Human Lymphocytes ◽  
Dna Unwinding ◽  
Pulsed Ultrasound ◽  
Radical Species ◽  
Fluorescent Analysis ◽  
Healthy Donors

SynopsisThe effects of ultrasound and ultraviolet radiation on Vitamin E and its pharmacological excipient, olive oil, were tested by fluorescent analysis of DNA unwinding (FADU) on DNA extracted from human lymphocytes of healthy donors. The results show that Vitamin E may be inactivated and behave as a radical species, while olive oil appears unaffected by treatment either with ultrasound or with ultraviolet radiation.

scholarly journals Role of Vitamin E on Indomethacin induced low pH of Seminal Fluid in Long Evans Rats

1970 ◽  
Vol 8 (1) ◽  
pp. 13-15
Author(s):  
Md Jahangir Alam ◽  
Humaira Naushaba ◽  
Uttam Kumar Paul ◽  
Tahmina Begum ◽  
Sunjida Shahriah ◽  
...  
Keyword(s):  
Body Weight ◽  
Vitamin E ◽  
Seminal Fluid ◽  
Low Ph ◽  
The Other ◽  
Testicular Damage ◽  
Other Hand ◽  
Long Evans ◽  
Different Doses

Context: Indomethacin is the most commonly and widely used nonsteroidal antinflammatory analgesic and antipyretic drug. Though it is effective drug in various diseases, indomethacin causes inhibition of spermatogenesis by lowering the pH of seminal fluid leading to infertility. On the other hand, vitamin E enhances spermatogenesis by increasing pH of the seminal fluid. Therefore, the present study was designed to observe the protective role of vitamin E on indomethacin induced low pH of seminal fluid in testicular damage. Objective: To observe the effects of vitamin E on indomethacin induced low pH of seminal fluid in testicular damage in Long Evans rats. Study design: An experimental study. Place and period of study: The study was carried out in the Department of Anatomy, Sir Salimullah Medical College, Dhaka in the period of August, 2005 to June, 2006. Materials and methods: Eightyfour mature Long Evans male rats were divided into four groups (I, II, III and IV). The rats of group I, II and III were treated with indomethacin at different doses and duration. Group IV rats were treated with indomethacin plus vitamin E at different doses for 49 days. The pH of seminal fluid were measured biochemically. Results: There was significant reduction (P<0.001) of pH of seminal fluid when the rats were treated with indomethacin at low (2 mg/kg body weight/day) and high (10 mg/kg body weight/day) doses for 7, 14 and 42 days, respectively. On the other hand, rats treated with indomethacin plus vitamin E for 49 days showed increase in pH of seminal fluid compared to other groups (P<0.001). Conclusion: It can be concluded from the study that vitamin E has potential role in the prevention of the antispermatogenic effects of indomethacin by increasing the pH of seminal fluid. Key words: seminal fluid; indomethacin; vitamin E   DOI: 10.3329/bja.v8i1.6103 Bangladesh Journal of Anatomy January 2010, Vol. 8 No. 1 pp. 13-15

scholarly journals Effects of Palm Vitamin E on Bone-Formation-Related Gene Expression in Nicotine-Treated Rats

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Seham Salem Ahmed Abukhadir ◽  
Norazlina Mohamed ◽  
Suzana Makpol ◽  
Norliza Muhammad
Keyword(s):  
Gene Expression ◽  
Vitamin E ◽  
Bone Formation ◽  
Olive Oil ◽  
Normal Saline ◽  
Bone Morphogenetic Protein 2 ◽  
Male Rats ◽  
Oral Supplementation ◽  
Nicotine Administration ◽  
Related Transcription Factor

The study determines the effects of palm vitamin E on the gene expression of bone-formation-related genes in nicotine-treated rats. Male rats were divided into three groups: normal saline olive oil (NSO), nicotine olive oil (NO), and nicotine palm vitamin E (NE). The treatment was carried out in 2 phases. During the first 2 months, the NSO group received normal saline while the NO and NE groups received nicotine 7 mg/kg, 6 days a week, intraperitoneally. The following 2 months, normal saline and nicotine administration was stopped and was replaced with oral supplementation of olive oil for the NSO and NO groups and oral supplementation of palm vitamin E (60 mg/kg) for the NE group. Both femurs were harvested to determine the gene expression of bone morphogenetic protein-2 (BMP-2), Osterix (OSX), and Runt-related transcription factor 2 (RUNX2). Nicotine significantly downregulated the gene expression. This effect was reversed by palm vitamin E treatment. In conclusion, palm vitamin E may play a role in osteoblast differentiation and can be considered as an anabolic agent to treat nicotine-induced osteoporosis.

THE EFFECT OF TOCOPHEROLS, OLIVE OIL, TESTOSTERONE, AND CORPUS LUTEUM EXTRACT (LUTEOCICLINA) UPON THE LESIONS CAUSED BY VITAMIN E DEFICIENCY

1949 ◽  
Vol 52 (3 Vitamin E) ◽  
pp. 144-147
Author(s):  
Enrique Pierangeli ◽  
Domingo Mosto ◽  
María Herraiz ◽  
Juan Carlos Radice ◽  
Francisco J. Cortada
Keyword(s):  
Vitamin E ◽  
Olive Oil ◽  
Corpus Luteum ◽  
Vitamin E Deficiency

scholarly journals Effects of Almond- and Olive Oil-Based Docosahexaenoic- and Vitamin E-Enriched Beverage Dietary Supplementation on Inflammation Associated to Exercise and Age

Nutrients ◽  
2016 ◽  
Vol 8 (10) ◽  
pp. 619 ◽  
Author(s):  
Xavier Capó ◽  
Miquel Martorell ◽  
Antoni Sureda ◽  
Joan Riera ◽  
Franchek Drobnic ◽  
...  
Keyword(s):  
Vitamin E ◽  
Olive Oil ◽  
Dietary Supplementation

THE EFFECT OF TOCOPHEROLS, OLIVE OIL, TESTOSTERONE, AND CORPUS LUTEUM EXTRACT (LUTEOCICLINA) UPON THE LESIONS CAUSED BY VITAMIN E DEFICIENCY

1949 ◽  
Vol 52 (3) ◽  
pp. 144-147
Author(s):  
Enrique Pierangeli ◽  
Domingo Mosto ◽  
María Herraiz ◽  
Juan Carlos Radice ◽  
Francisco J. Cortada
Keyword(s):  
Vitamin E ◽  
Olive Oil ◽  
Corpus Luteum ◽  
Vitamin E Deficiency

Vitamin C ameliorates fluoride-induced embryotoxicity in pregnant rats

2001 ◽  
Vol 20 (12) ◽  
pp. 619-623 ◽  
Author(s):  
R J Verma ◽  
D M Guna Sherlin
Keyword(s):  
Body Weight ◽  
Vitamin E ◽  
Vitamin C ◽  
Oral Administration ◽  
Olive Oil ◽  
Feed Consumption ◽  
Uterine Weight ◽  
Pregnant Rats ◽  
Total Percentage ◽  
C 50

Oral administration of sodium fluoride (40 mg/kg body weight) from day 6 to 19 of gestation caused, as compared to control, significant reductions in body weight, feed consumption, absolute uterine weight and number of implantations. Significantly higher incidence of skeletal (wavy ribs, 14th rib, <6 sternal centre, dumbell-shaped second and fifth sternebrae, incomplete ossification of skull and thickening of tibia) and visceral (subcutaneous haemorrhage) abnormalities were also observed in NaF-treated dams than that of control. Oral administration of vitamin C (50 mg/kg body weight) and vitamin E (2 mg/0.2 ml olive oil/animal/day) from day 6 to 19 of gestation along with NaF significantly ameliorates NaF-induced reductions in body weight, feed consumption, absolute uterine weight (only with vitamin E treatment) and number of implantations. As compared with NaF-treated alone, the total percentage of skeletal and visceral abnormalities were significantly lowered in fluoride plus vitamin C-treated animals. Vitamin E was less effective. These findings suggest that vitamin C significantly reduced the severity and incidence of fluoride-induced embryotoxicity in rats.

scholarly journals Effects of Dietary Conjugated Linoleic Acid and Selected Vegetable Oils or Vitamin E on Fatty Acid Composition of Hen Egg Yolks

2019 ◽  
Vol 19 (1) ◽  
pp. 173-188
Author(s):  
Magdalena Franczyk-Żarów ◽  
Beata Szymczyk ◽  
Renata B. Kostogrys
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Linoleic Acid ◽  
Vitamin E ◽  
Olive Oil ◽  
Conjugated Linoleic Acid ◽  
Vegetable Oils ◽  
Rapeseed Oil ◽  
Standard Diet ◽  
Egg Yolks

AbstractThe objective of this study was to produce eggs enriched with conjugated linoleic acid (CLA) and ameliorate their fatty acid profile using the appropriate combination of dietary CLA with or without vegetable oils (olive oil or rapeseed oil) and vitamin E. In Experiment 1, 25-week-old laying hens were randomly distributed into eight groups of nine. Birds were fed with a standard diet with four different levels of CLA (0.0, 0.5, 0.75, 1.0%) and vegetable oils (olive oil or rapeseed oil, both in the amount of 1.46%). In Experiment 2, hens were randomly distributed into 12 groups of nine. The same four levels of CLA with three doses of vitamin E (0, 150, 300 mg/kg of diet) were applied. In both experiments, eggs were collected twice (at 4 and 8 weeks) for fatty acid profiling using GCMS. The differences between treatment means were considered significant at P<0.05. CLA treatments significantly increased the content of CLA, saturated fatty acids (SFA), and significantly decreased the content of monounsaturated fatty acids (MUFA) in the egg yolk, whereas levels of polyunsaturated fatty acids (PUFA) were unaffected. The vegetable oils used did not prevent the negative effects of CLA effectively. Only after eight weeks of experiment 1 SFA levels were significantly lower, but MUFA levels were significantly higher in groups fed with rapeseed oil compared to groups fed with olive oil. In experiment 2, the addition of vitamin E to the hen diet did not have an essential influence on the lipid profile of egg yolks.

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