The influence of a combination of lifestyle modification and a new formula supplement with antioxidative and antioestrogenic activity on mild idiopathic abnormalities of semen parameters—A pilot study

Andrologia ◽  
2021 ◽  
Author(s):  
Jolanta Slowikowska‐Hilczer ◽  
Renata Walczak‐Jedrzejowska ◽  
Piotr Dobronski
Keyword(s):  
Pilot Study ◽  
Lifestyle Modification ◽  
Semen Parameters ◽  
New Formula

scholarly journals A pilot study of acceptance-based behavioural weight loss for adolescents with obesity

2019 ◽  
Vol 47 (6) ◽  
pp. 686-696 ◽  
Author(s):  
Jena Shaw Tronieri ◽  
Thomas A. Wadden ◽  
Sharon M. Leonard ◽  
Robert I. Berkowitz
Keyword(s):  
Physical Activity ◽  
Weight Loss ◽  
Pilot Study ◽  
Lifestyle Modification ◽  
Psychological Treatment ◽  
Psychosocial Outcomes ◽  
Cognitive Restraint ◽  
Acceptance And Commitment ◽  
Medium Increase

AbstractBackground:Acceptance and commitment therapy (ACT) is a psychological treatment that has been found to increase weight loss in adults when combined with lifestyle modification, compared with the latter treatment alone. However, an ACT-based treatment for weight loss has never been tested in adolescents.Methods:The present pilot study assessed the feasibility and acceptability of a 16-week, group ACT-based lifestyle modification treatment for adolescents and their parents/guardians. The co-primary outcomes were: (1) mean acceptability scores from up to 8 biweekly ratings; and (2) the percentage reduction in body mass index (BMI) from baseline to week 16. The effect size for changes in cardiometabolic and psychosocial outcomes from baseline to week 16 also was examined.Results:Seven families enrolled and six completed treatment (14.3% attrition). The mean acceptability score was 8.8 for adolescents and 9.0 for parents (on a 1–10 scale), indicating high acceptability. The six adolescents who completed treatment experienced a 1.3% reduction in BMI (SD = 2.3, d = 0.54). They reported a medium increase in cognitive restraint, a small reduction in hunger, and a small increase in physical activity. They experienced small improvements in most quality of life domains and a large reduction in depression.Conclusions:These preliminary findings indicate that ACT plus lifestyle modification was a highly acceptable treatment that improved weight, cognitive restraint, hunger, physical activity, and psychosocial outcomes in adolescents with obesity.

scholarly journals Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Vijay R. Ambiye ◽  
Deepak Langade ◽  
Swati Dongre ◽  
Pradnya Aptikar ◽  
Madhura Kulkarni ◽  
...  
Keyword(s):  
Pilot Study ◽  
Withania Somnifera ◽  
Sperm Count ◽  
Day Treatment ◽  
Treated Group ◽  
Semen Parameters ◽  
Root Extract ◽  
Full Spectrum ◽  
Hormone Levels ◽  
Serum Hormone

Ashwagandha (Withania somnifera) has been described in traditional Indian Ayurvedic medicine as an aphrodisiac that can be used to treat male sexual dysfunction and infertility. This pilot study was conducted to evaluate the spermatogenic activity of Ashwagandha root extract in oligospermic patients. Forty-six male patients with oligospermia (sperm count < 20 million/mL semen) were enrolled and randomized either to treatment (n=21) with a full-spectrum root extract of Ashwagandha (675 mg/d in three doses for 90 days) or to placebo (n=25) in the same protocol. Semen parameters and serum hormone levels were estimated at the end of 90-day treatment. There was a 167% increase in sperm count (9.59 ± 4.37 × 106/mL to 25.61 ± 8.6 × 106/mL;P<0.0001), 53% increase in semen volume (1.74 ± 0.58 mL to 2.76 ± 0.60 mL;P<0.0001), and 57% increase in sperm motility (18.62 ± 6.11% to 29.19 ± 6.31%;P<0.0001) on day 90 from baseline. The improvement in these parameters was minimal in the placebo-treated group. Furthermore, a significantly greater improvement and regulation were observed in serum hormone levels with the Ashwagandha treatment as compared to the placebo. The present study adds to the evidence on the therapeutic value of Ashwagandha (Withania somnifera), as attributed in Ayurveda for the treatment of oligospermia leading to infertility.

scholarly journals A single-arm pilot study on effects of acupuncture treatment on semen parameters of subfertile Singaporean men

2015 ◽  
Vol 4 (4) ◽  
pp. 266-271
Author(s):  
Lee Mee Ho ◽  
Shu Li Chui ◽  
Siew Chen Hum ◽  
Johnny Qi Ming Foo ◽  
Stephanie Man Chung Fook-Chong ◽  
...  
Keyword(s):  
Pilot Study ◽  
Acupuncture Treatment ◽  
Semen Parameters

Abstract P314: Response of the Cardiometabolic Risk Profile to Coronary Artery Bypass Surgery Followed by a 1-year Lifestyle Modification Program: A Pilot Study

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Valérie Lévesque ◽  
Paul Poirier ◽  
André Marette ◽  
Patrick Mathieu ◽  
Jean-Pierre Després ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Coronary Artery ◽  
Pilot Study ◽  
Total Cholesterol ◽  
Cardiometabolic Risk ◽  
Lifestyle Modification ◽  
Artery Bypass ◽  
Abdominal Adipose Tissue ◽  
Cabg Surgery ◽  
Lifestyle Modification Program

Introduction: A coronary artery bypass graft (CABG) surgery induces an important physiological stress which could impact on cardiometabolic risk (CMR) variables. Furthermore, lifestyle modification programs are effective in secondary prevention. Objective: The present pilot study explored the response of CMR variables to a CABG surgery followed by a 1-year intervention targeting the improvement of lifestyle habits (nutrition/physical activity) in patients with established coronary artery disease (CAD). Methods: Anthropometric measurements, assessment of lipid profile and magnetic resonance imaging were performed before and after CABG surgery (n=32) and 1 year after the lifestyle modification program (n=26). An oral glucose tolerance test (OGTT) and a maximal treadmill test (modified Bruce) were also performed after surgery and at the end of the intervention program. Results: Six weeks after surgery, but before initiation of the lifestyle modification program, patients significantly reduced their body mass index (BMI) (Δ=−1.0 kg/m 2 , p<0.0001), waist circumference (Δ=−3.4 cm, p<0.0001), fat mass (Δ=−2.7 kg, p<0.0001), visceral (Δ=−25.5 cm 3 , p=0.007) and total abdominal adipose tissue volumes (Δ=−27.4 cm 3 , p=0.008). They also significantly decreased their LDL-C (Δ=−0.7 mmol/L, p=0.0003) and total cholesterol (Δ=−0.7 mmol/L, p<0.0001), as well as their total cholesterol/HDL-C ratio (Δ=−0.8, p=0.009). In response to the lifestyle modification program, subjects further improved their CMR profile with additional decreases in their BMI (Δ=−0.9 kg/m 2 , p=0.02) and waist circumference (Δ=−4.3 cm, p=0.002) as well as visceral (Δ=−36.2 cm 3 , p=0.03), subcutaneous (Δ=−29.1 cm 3 , p=0.005) and total abdominal adipose tissue volumes (Δ=−61.1 cm 3 , p=0.01). They also significantly reduced glucose area under the curve (Δ=−128.6 ρmol/L, p=0.0005) measured during the OGTT, TG/HDL-C ratio (Δ=−0.47, p=0.0006), triglycerides (Δ=−0.12 mmol/L, p=0.03), total cholesterol/HDL-C ratio (Δ=−0.34, p=0.003) and increased HDL-C levels (Δ=+0.2 mmol/L, p=0.0002). Cardiorespiratory fitness (CRF) was also improved significantly as reflected by an increase in VO 2 max (Δ=+4.0 mlO 2 /kg/min, p<0.0001) and by a reduced heart rate assessed at a standardized workload (3.5 mph, 2% slope) (Δ=−9 bpm, p<0.0001). All changes in cardiometabolic risk variables were observed despite a reduction in the use of cardiometabolic drugs in some patients. A multiple regression analysis showed that improvement in CRF largely explained (r 2 =0.61, p=0.0003) the improvement in 2-hours plasma glucose (OGTT) in response to the lifestyle modification program. Conclusion: Results of this pilot study suggest that the CMR profile of high risk patients with CAD is improved by the CABG surgery itself. In addition, a 1-year lifestyle modification program generates further cardiometabolic benefits.

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