MiR‐622 acts as a tumor suppressor to induce cell apoptosis and inhibit metastasis in human prostate cancer

Andrologia ◽  
2021 ◽  
Author(s):  
Niloufar Targhazeh ◽  
Bahman Yousefi ◽  
Samira Asghari ◽  
Reza Mohammadnejhad ◽  
Parinaz Mansouri ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Cell Apoptosis ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Induce Cell Apoptosis

SOCS6 Functions as a Tumor Suppressor by Inducing Apoptosis and Inhibiting Angiogenesis in Human Prostate Cancer

2018 ◽  
Vol 18 (9) ◽  
pp. 894-904 ◽  
Author(s):  
Dongbo Yuan ◽  
Wei Wang ◽  
Jiaming Su ◽  
Yongqiang Zhang ◽  
Boshi Luan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Cell Apoptosis ◽  
Human Prostate ◽  
Migration And Invasion ◽  
Cytokine Signaling ◽  
Pathway Enrichment Analysis ◽  
Sequencing Analysis ◽  
Human Prostate Cancer

Background: Our previous studies revealed that the downregulation of Suppressor of cytokine signaling 6 (SOCS6) was correlated with malignant progression of human prostate cancer (PCa). Aims: In the current study, we aimed to investigate the tumor suppressive roles of SOCS6 and the underlying mechanisms in PCa. Methods: SOCS6 expression in PCa and non-cancerous prostate tissues was compared by immunohistochemistry. Statistical associations of SOCS6 expression with various clinicopathological features and patients prognosis were evaluated. In addition, we investigated SOCS6’s functions by overexpressing it in vitro (cell apoptosis, migration and invasion assays) and in vivo (tumor formation, angiogenesis and apoptosis). Moreover, SOCS6-regulated genes were identified by nextgeneration RNA-sequencing analysis, followed by pathway enrichment analysis and in vitro experimental validation. Results: SOCS6 downregulation was significantly associated with advanced clinical stage (P=0.029) and positive lymph node metastasis (P=0.013) in PCa patients. We also identified SOCS6 as an independent prognostic factor for disease-free survival in PCa patients (P=0.045). Moreover, overexpression of SOCS6 inhibited PCa cell invasion, migration, tumor xenografts growth and angiogenesis, but induced PCa cell apoptosis (P values <0.05). Mechanically, we revealed that SOCS6 expression may induce cell apoptosis coincident with down-regulation of Bcl2 and Hspa1a, and may suppress tumor angiogenesis with downregulation of F7, Fak3 and Frzb. Conclusion: These findings suggest that the reduced expression of SOCS6 may be predictive of unfavorable prognosis in PCa. Thus, SOCS6 may serve as a tumor suppressor and a novel therapeutic target for this cancer.

MP-03.01 Functional Role of PGP 9.5 as Tumor Suppressor is Inactivated by Promoter CpG Methylation in Human Prostate Cancer

Urology ◽  
2011 ◽  
Vol 78 (3) ◽  
pp. S41
Author(s):  
Y. Mitsui ◽  
M. Hiraki ◽  
N. Arichi ◽  
T. Hiraoka ◽  
M. Sumura ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Functional Role ◽  
Cpg Methylation ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Pgp 9.5

scholarly journals 3p21.3 tumor suppressor gene RBM5 inhibits growth of human prostate cancer PC-3 cells through apoptosis

2012 ◽  
Vol 10 (1) ◽  
pp. 247 ◽  
Author(s):  
Lijing Zhao ◽  
Ranwei Li ◽  
Chen Shao ◽  
Ping Li ◽  
Jian Liu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Human Prostate ◽  
Human Prostate Cancer

scholarly journals Correction: Effects of interferons and double-stranded RNA on human prostate cancer cell apoptosis

Oncotarget ◽  
2019 ◽  
Vol 10 (57) ◽  
pp. 6044-6044
Author(s):  
Haiyan Tan ◽  
Chun Zeng ◽  
Junbo Xie ◽  
Norah J. Alghamdi ◽  
Ya Song ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Prostate Cancer Cell ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Human Prostate Cancer Cell ◽  
Double Stranded Rna ◽  
Cancer Cell Apoptosis

Long Noncoding RNA IGF2AS is Acting as an Epigenetic Tumor Suppressor in Human Prostate Cancer

Urology ◽  
2019 ◽  
Vol 124 ◽  
pp. 310.e1-310.e8 ◽  
Author(s):  
Qiang Chen ◽  
Ting Sun ◽  
Fang Wang ◽  
Binbin Gong ◽  
Wenjie Xie ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Human Prostate ◽  
Human Prostate Cancer

Localization of a tumor suppressor gene associated with progression of human prostate cancer within a 1.2 Mb region of 8p22-p21.3

1995 ◽  
Vol 13 (3) ◽  
pp. 168-174 ◽  
Author(s):  
Hiroyoshi Suzuki ◽  
Miburu Emi ◽  
Akira Komiya ◽  
Yoshiyuki Fujiwara ◽  
Ryuichi Yatani ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Human Prostate ◽  
Human Prostate Cancer

Thioredoxin interacting protein (TXNIP) acts as a tumor suppressor in human prostate cancer

2020 ◽  
Vol 44 (10) ◽  
pp. 2094-2106 ◽  
Author(s):  
Ming Xie ◽  
Ruiyan Xie ◽  
Sen Xie ◽  
Yiyi Wu ◽  
Wei Wang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Interacting Protein ◽  
Thioredoxin Interacting Protein

scholarly journals Upregulation of PAWR by small activating RNAs induces cell apoptosis in human prostate cancer cells

2016 ◽  
Vol 35 (4) ◽  
pp. 2487-2493 ◽  
Author(s):  
KAI YANG ◽  
JIE SHEN ◽  
SHAN-WEN CHEN ◽  
JIE QIN ◽  
XIANG-YI ZHENG ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Cell Apoptosis ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells

scholarly journals Snail transcription factor negatively regulates maspin tumor suppressor in human prostate cancer cells

BMC Cancer ◽  
2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Corey L Neal ◽  
Veronica Henderson ◽  
Bethany N Smith ◽  
Danielle McKeithen ◽  
Tisheeka Graham ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Transcription Factor ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells

scholarly journals ADAMTS-15 Has a Tumor Suppressor Role in Prostate Cancer

Biomolecules ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 682 ◽  
Author(s):  
Marley J. Binder ◽  
Scott McCoombe ◽  
Elizabeth D. Williams ◽  
Daniel R. McCulloch ◽  
Alister C. Ward
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Cancer Cell ◽  
Cancer Progression ◽  
Prostate Cancer Cell ◽  
Human Prostate ◽  
Matrix Remodeling ◽  
Human Prostate Cancer ◽  
Enzymatic Function

Extracellular matrix remodeling has emerged as an important factor in many cancers. Proteoglycans, including versican (VCAN), are regulated via cleavage by the proteolytic actions of A Disintegrin-like And Metalloproteinase domain with Thrombospondin-1 motif (ADAMTS) family members. Alterations in the balance between Proteoglycans and ADAMTS enzymes have been proposed to contribute to cancer progression. Here, we analyzed the expression of ADAMTS-15 in human prostate cancer, and investigated the effects of enforced expression in prostate cancer cell lines. ADAMTS-15 was found to be expressed in human prostate cancer biopsies with evidence of co-localization with VCAN and its bioactive cleavage fragment versikine. Enforced expression of ADAMTS-15, but not a catalytically-inactive version, decreased cell proliferation and migration of the ‘castrate-resistant’ PC3 prostate cancer cell line in vitro, with survival increased. Analysis of ‘androgen-responsive’ LNCaP prostate cancer cells in vivo in NOD/SCID mice revealed that ADAMTS-15 expression caused slower growing tumors, which resulted in increased survival. This was not observed in castrated mice or with cells expressing catalytically-inactive ADAMTS-15. Collectively, this research identifies the enzymatic function of ADAMTS-15 as having a tumor suppressor role in prostate cancer, possibly in concert with androgens, and that VCAN represents a likely key substrate, highlighting potential new options for the clinic.

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