Thioredoxin interacting protein (TXNIP) acts as a tumor suppressor in human prostate cancer

2020 ◽  
Vol 44 (10) ◽  
pp. 2094-2106 ◽  
Author(s):  
Ming Xie ◽  
Ruiyan Xie ◽  
Sen Xie ◽  
Yiyi Wu ◽  
Wei Wang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Interacting Protein ◽  
Thioredoxin Interacting Protein

MP-03.01 Functional Role of PGP 9.5 as Tumor Suppressor is Inactivated by Promoter CpG Methylation in Human Prostate Cancer

Urology ◽  
2011 ◽  
Vol 78 (3) ◽  
pp. S41
Author(s):  
Y. Mitsui ◽  
M. Hiraki ◽  
N. Arichi ◽  
T. Hiraoka ◽  
M. Sumura ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Functional Role ◽  
Cpg Methylation ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Pgp 9.5

scholarly journals 3p21.3 tumor suppressor gene RBM5 inhibits growth of human prostate cancer PC-3 cells through apoptosis

2012 ◽  
Vol 10 (1) ◽  
pp. 247 ◽  
Author(s):  
Lijing Zhao ◽  
Ranwei Li ◽  
Chen Shao ◽  
Ping Li ◽  
Jian Liu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Human Prostate ◽  
Human Prostate Cancer

MLF1 interacting protein: a potential gene therapy target for human prostate cancer?

2015 ◽  
Vol 32 (2) ◽  
Author(s):  
Lei Zhang ◽  
Guoqing Ji ◽  
Yuzhang Shao ◽  
Shaoyi Qiao ◽  
Yuming Jing ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Gene Therapy ◽  
Protein A ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Interacting Protein ◽  
Therapy Target

Long Noncoding RNA IGF2AS is Acting as an Epigenetic Tumor Suppressor in Human Prostate Cancer

Urology ◽  
2019 ◽  
Vol 124 ◽  
pp. 310.e1-310.e8 ◽  
Author(s):  
Qiang Chen ◽  
Ting Sun ◽  
Fang Wang ◽  
Binbin Gong ◽  
Wenjie Xie ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Human Prostate ◽  
Human Prostate Cancer

Localization of a tumor suppressor gene associated with progression of human prostate cancer within a 1.2 Mb region of 8p22-p21.3

1995 ◽  
Vol 13 (3) ◽  
pp. 168-174 ◽  
Author(s):  
Hiroyoshi Suzuki ◽  
Miburu Emi ◽  
Akira Komiya ◽  
Yoshiyuki Fujiwara ◽  
Ryuichi Yatani ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Human Prostate ◽  
Human Prostate Cancer

scholarly journals Snail transcription factor negatively regulates maspin tumor suppressor in human prostate cancer cells

BMC Cancer ◽  
2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Corey L Neal ◽  
Veronica Henderson ◽  
Bethany N Smith ◽  
Danielle McKeithen ◽  
Tisheeka Graham ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Transcription Factor ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells

scholarly journals ADAMTS-15 Has a Tumor Suppressor Role in Prostate Cancer

Biomolecules ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 682 ◽  
Author(s):  
Marley J. Binder ◽  
Scott McCoombe ◽  
Elizabeth D. Williams ◽  
Daniel R. McCulloch ◽  
Alister C. Ward
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Cancer Cell ◽  
Cancer Progression ◽  
Prostate Cancer Cell ◽  
Human Prostate ◽  
Matrix Remodeling ◽  
Human Prostate Cancer ◽  
Enzymatic Function

Extracellular matrix remodeling has emerged as an important factor in many cancers. Proteoglycans, including versican (VCAN), are regulated via cleavage by the proteolytic actions of A Disintegrin-like And Metalloproteinase domain with Thrombospondin-1 motif (ADAMTS) family members. Alterations in the balance between Proteoglycans and ADAMTS enzymes have been proposed to contribute to cancer progression. Here, we analyzed the expression of ADAMTS-15 in human prostate cancer, and investigated the effects of enforced expression in prostate cancer cell lines. ADAMTS-15 was found to be expressed in human prostate cancer biopsies with evidence of co-localization with VCAN and its bioactive cleavage fragment versikine. Enforced expression of ADAMTS-15, but not a catalytically-inactive version, decreased cell proliferation and migration of the ‘castrate-resistant’ PC3 prostate cancer cell line in vitro, with survival increased. Analysis of ‘androgen-responsive’ LNCaP prostate cancer cells in vivo in NOD/SCID mice revealed that ADAMTS-15 expression caused slower growing tumors, which resulted in increased survival. This was not observed in castrated mice or with cells expressing catalytically-inactive ADAMTS-15. Collectively, this research identifies the enzymatic function of ADAMTS-15 as having a tumor suppressor role in prostate cancer, possibly in concert with androgens, and that VCAN represents a likely key substrate, highlighting potential new options for the clinic.

Sign in / Sign up

Export Citation Format

Share Document