Impacts of n‐acetyl cysteine on gibberellic acid‐induced testicular dysfunction through regulation of inflammatory cytokines, steroid and antioxidant activity

Andrologia ◽  
2021 ◽  
Author(s):  
Mohamed Mohamed Soliman ◽  
Adil Aldhahrani ◽  
Ahmed Gaber ◽  
Walaa F. Alsanie ◽  
Mustafa Shukry ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Gibberellic Acid ◽  
Inflammatory Cytokines ◽  
Testicular Dysfunction ◽  
Acetyl Cysteine

scholarly journals CPU86017-RS attenuate hypoxia-induced testicular dysfunction in mice by normalizing androgen biosynthesis genes and pro-inflammatory cytokines

2012 ◽  
Vol 33 (4) ◽  
pp. 470-478 ◽  
Author(s):  
Guo-lin Zhang ◽  
Feng Yu ◽  
De-zai Dai ◽  
Yu-si Cheng ◽  
Can Zhang ◽  
...  
Keyword(s):  
Inflammatory Cytokines ◽  
Testicular Dysfunction ◽  
Pro Inflammatory Cytokines

Mitigation of IL-1β, IL-6, TNF-α, and markers of apoptosis by ursolic acid against cisplatin-induced oxidative stress and nephrotoxicity in rats

2021 ◽  
Vol 40 (12_suppl) ◽  
pp. S397-S405
Author(s):  
Pankaj Tripathi ◽  
Saeed Alshahrani
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Uric Acid ◽  
Inflammatory Cytokines ◽  
Caspase 3 ◽  
Caspase 9 ◽  
Histological Damage ◽  
Tnf Α ◽  
Mda Content ◽  
Pro Inflammatory Cytokines

Background: Ursolic acid (UA) is a natural pentacyclic triterpenoid that is known for its benefits under several pathological conditions. Cisplatin (CP) is among the most preferred chemotherapeutic agents; however, its nephrotoxicity limits its clinical utility. Purpose: This study was aimed to determine the role of UA in the reduction of CP-induced nephrotoxicity and mitigation of pro-inflammatory cytokines and apoptosis in a rat model. Methodology: Male Wistar rats were randomized into vehicle control, CP (7.5 mg/kg), UA 10 mg/kg, and CP with UA 5 and 10 mg/kg groups. Kidney and blood samples were collected for assessment of renal function, measurement of pro-inflammatory cytokines, apoptosis markers, antioxidant activity, and tissue histology. Results: CP significantly increased the levels of serum Cr, BUN, and uric acid; it also induced histological damage reflecting the pathophysiology observed during nephrotoxicity. CP has also shown its pro-oxidant activity in kidney tissue because CP decreased the levels of GSH, SOD, and CAT; it increased the lipid peroxidation as measured by MDA content. In addition, CP significantly upregulated the activity of pro-inflammatory cytokines and expression of apoptotic markers, that is, there were increased levels of IL-1β, IL-6, TNF-α, caspase-3, and caspase-9. Two weeks of continuous treatment of UA showed significant recovery against CP-induced nephrotoxicity; UA decreased the levels of Cr, BUN, and uric acid and ameliorated histological damage. UA also downregulated the activities of IL-1β, IL-6, and TNF-α as well as expression of caspase-3 and caspase-9. Furthermore, CP-induced oxidative stress that was antagonized by UA—the levels of GSH, SOD, and CAT were significantly increased while MDA content was decreased. Conclusions: UA has a protective effect against CP-induced nephrotoxicity, which may be due to its antioxidant activity and mitigation of ILβ-1, ILβ-6, TNF-α, and markers of apoptosis.

scholarly journals Hepatoprotective and antioxidant activity of N-acetyl cysteine in carbamazepine-administered rats

2014 ◽  
Vol 46 (2) ◽  
pp. 211 ◽  
Author(s):  
Eswaran Maheswari ◽  
Ganesan RajaLekshmi Saraswathy ◽  
Thakur Santhranii
Keyword(s):  
Antioxidant Activity ◽  
Acetyl Cysteine

scholarly journals Does Coenzyme Q10 Supplementation Improve Testicular Function and Spermatogenesis in Male Mice with Chronic Kidney Disease?

Biology ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 786
Author(s):  
Chih-Wei Tsao ◽  
Yu-Juei Hsu ◽  
Xiang-Ting Tseng ◽  
Ting-Chia Chang ◽  
Chang-Huei Tsao ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Antioxidant Activity ◽  
Kidney Disease ◽  
Coenzyme Q10 ◽  
Corn Oil ◽  
Semen Quality ◽  
Reproductive Function ◽  
Study Groups ◽  
Testicular Dysfunction ◽  
Testicular Morphology

The aim of the study was to examine the potential effects of coenzyme Q10 (CoQ10) on reproductive function in a chronic kidney disease (CKD) mouse model. Nine-week-old mice were randomly assigned to two groups: sham surgery (n = 18) and CKD surgery (n = 18). After surgery, the study groups received CoQ10 (10 mg/kg body weight dissolved in corn oil by oral gavage) or corn oil as a vehicle daily for 8 weeks. The groups that underwent 5/6 nephrectomy developed significant elevations of serum BUN and creatinine levels. The CoQ10 treatment significantly increased the serum and testicular CoQ10 levels and alleviated the poor semen quality from incomplete spermatogenesis. The testosterone concentration, in addition to the protein expression of enzymes related to testosterone biosynthesis, was also elevated, and the CKD-induced decrease in antioxidant activity in the testes was significantly ameliorated. The results suggest that CoQ10 could act against CKD-induced testicular dysfunction through improvements in the sperm function, testicular morphology, testosterone levels and related biosynthesis pathways, in addition to antioxidant activity.

scholarly journals CABBAGE KALE – A NEW FUNCTIONAL FOOD PRODUCT: GROWING CONDITIONS AND REGULATION OF THE PHYTOCHEMICAL COMPOSITION

2020 ◽  
Vol 8 (Spl-2-AABAS) ◽  
pp. S264-S271
Author(s):  
Esraa Almughraby ◽  
◽  
Marat Ildusovich Kalimullin ◽  
Antonina Mostyakova Anatolyevna ◽  
Olga Arnoldovna Timofeeva ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Gibberellic Acid ◽  
Growth Regulators ◽  
Antioxidant Activities ◽  
Food Product ◽  
Antioxidant Systems ◽  
Enzymatic Antioxidants ◽  
Plant Seed ◽  
Specific Effects ◽  
Growing Conditions

The purpose of this work was to evaluate the specific effects of natural growth hormones (gibberellic acid, 10-6М and brassinolide, 10-6М) and commercial growth bio-stimulator (Novosil, 5 g/ha) on the enzymatic and non-enzymatic antioxidants activities of cabbage kale plants, under different growing conditions. The treatment of growth regulators was imposed by soaking cabbage kale plant seed in various growth regulators for 24 hours. The results were recorded at 85, 115 and 145 days after planting, at +80С, 00С and -60С temperature, respectively. Among the studied growth regulators, terpenoidal compounds of Novosil and gibberellic acid improved the antioxidant activity, activating enzymatic antioxidant systems and increasing the content of carotenoids and proline in leaves of cabbage kale. The steroidal compound of brassinolide raises the content of phenolic and flavonoids compounds which increased antioxidant activities. The results obtained from the study indicated that the use of growth regulars increases the synthesis of protective compounds, which developed resistance of cabbage kale plants against adverse environmental factors and improve the biomedical properties of cabbage kale. Further, the results of the study also suggested that freezing temperatures (-60С) enhanced the protective effect of growth regulators against lipid peroxidation and their antioxidant activity.

A Pilot Study to Evaluate the Effects of Oral N-Acetyl Cysteine on Inflammatory and Oxidative Stress Biomarkers in Rheumatoid Arthritis

2019 ◽  
Vol 15 (3) ◽  
pp. 246-253 ◽  
Author(s):  
Ghazal Hashemi ◽  
Mahtabalsadat Mirjalili ◽  
Zahra Basiri ◽  
Ahmad Tahamoli-Roudsari ◽  
Nejat Kheiripour ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Oxidative Stress ◽  
Placebo Group ◽  
Inflammatory Cytokines ◽  
Serum Levels ◽  
Stress Factors ◽  
Oxidative Stress Biomarkers ◽  
Significant Difference ◽  
Acetyl Cysteine ◽  
And Oxidative Stress

<P>Background: Rheumatoid Arthritis (RA) is a common inflammatory disease of the joints. Due to the importance of inflammation and oxidative stress in the pathogenesis of RA, drugs that have anti-oxidant and anti-inflammatory properties, such as N-acetyl Cysteine (NAC), can be used as adjunctive therapy in patients with RA. </P><P> Aims: The aim of this study was to evaluate the effects of oral NAC on inflammatory cytokines and oxidative stress in patients with RA. </P><P> Methods: Adjunct to standard treatment, the NAC group (23 patients) received 600 mg of NAC twice daily and the placebo group (19 patients) received identical placebo twice daily for 12 weeks. Serum levels of Total Oxidant Status (TOS), Total Antioxidant Capacity (TAC), nitric oxide (NO), Total Thiol Groups (TTG), Malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-&#945;), interleukin- 6 (IL-6), C-reactive Protein (CRP), and Erythrocyte Sedimentation Rate (ESR) were measured at baseline and at the end of the study. </P><P> Results: Results showed that in the NAC group, the serum levels of MDA, NO, IL-6, TNF-&#945;, ESR and CRP were significantly lower than the baseline. Also, the serum level of TAC and TTG, as antioxidant parameters, increased significantly. However, only NO, MDA and TTG showed a significant difference in the NAC group as compared to the placebo group at the end of study. </P><P> Conclusion: According to the results of this study, oral NAC can significantly reduce the several oxidative stress factors and inflammatory cytokines. These results need to be confirmed in larger studies while considering clinical outcomes of RA patients.</P>

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