The protective effect of Kombucha against silver nanoparticles‐induced toxicity on testicular tissue in NMRI mice

Andrologia ◽  
2021 ◽  
Author(s):  
Seyed Mohammad Ali Shariatzadeh ◽  
Seyede Azam Miri ◽  
Ebrahim Cheraghi
Keyword(s):  
Silver Nanoparticles ◽  
Protective Effect ◽  
Testicular Tissue ◽  
Nmri Mice

Evaluation of the toxic effect of silver nanoparticles and the possible protective effect of ascorbic acid on the parotid glands of albino rats: An in vivo study

2020 ◽  
Vol 36 (6) ◽  
pp. 446-453
Author(s):  
Salma Awad Taghyan ◽  
Hend El Messiry ◽  
Medhat Ahmed El Zainy
Keyword(s):  
Silver Nanoparticles ◽  
Ascorbic Acid ◽  
Vitamin C ◽  
Protective Effect ◽  
Toxic Effect ◽  
Toxic Effects ◽  
Control Group ◽  
Albino Rats ◽  
Parotid Glands ◽  
Ductal Cells

This study aimed to evaluate the toxic effect of silver nanoparticles (AgNPs) on the parotid glands (PGs) of albino rats histologically and ultrastructurally and assess the possible protective effect of ascorbic acid as an antioxidant. Thirty male albino rats weighing between 150 mg and 200 mg were divided into three groups: the control group (C1) contained 10 rats that received 2 mg/kg (body weight (bw)) of aqueous nitrate buffer by intraperitoneal (IP) injection daily for 28 days; the AgNPs group contained 10 rats that received 2 mg/kg (bw) IP AgNPs daily for 28 days; and the AgNPs-vitamin C group contained 10 albino rats that received 2 mg/kg (bw) AgNPs IP daily for 28 days with oral administration of 100 mg/kg (bw) vitamin C in drinking water daily for 28 days. The PG acinar and ductal cells of the AgNPs group showed signs of toxicity and degeneration characterized as pleomorphic nuclei, binucleation, cytoplasmic vacuolations, and stagnated secretion in the ductal lumen. In addition to degenerated mitochondria, dilated rough endoplasmic reticulum and lysosomes were filled with AgNPs ( p < 0.001). The AgNPs-vitamin C group showed significantly less degenerative changes histologically and ultrastructurally compared to the AgNPs group ( p = 0.002). AgNPs produced significant toxic effects on the PG of albino rats, presumably through the generation of reactive oxygen species and toxic ion release, and administration of vitamin C was shown effective in decreasing these toxic effects.

scholarly journals Mitochondrial Peptide Humanin Protects Silver Nanoparticles-Induced Neurotoxicity in Human Neuroblastoma Cancer Cells (SH-SY5Y)

2019 ◽  
Vol 20 (18) ◽  
pp. 4439 ◽  
Author(s):  
Gurunathan ◽  
Jeyaraj ◽  
Kang ◽  
Kim
Keyword(s):  
Oxidative Stress ◽  
Silver Nanoparticles ◽  
Protective Effect ◽  
Anticancer Agents ◽  
Membrane Integrity ◽  
Neuroblastoma Cells ◽  
Human Beings ◽  
Human Neuroblastoma ◽  
Cellular Effects ◽  
Harmful Effects

The extensive usage of silver nanoparticles (AgNPs) as medical products such as antimicrobial and anticancer agents has raised concerns about their harmful effects on human beings. AgNPs can potentially induce oxidative stress and apoptosis in cells. However, humanin (HN) is a small secreted peptide that has cytoprotective and neuroprotective cellular effects. The aim of this study was to assess the harmful effects of AgNPs on human neuroblastoma SH-SY5Y cells and also to investigate the protective effect of HN from AgNPs-induced cell death, mitochondrial dysfunctions, DNA damage, and apoptosis. AgNPs were prepared with an average size of 18 nm diameter to study their interaction with SH-SY5Y cells. AgNPs caused a dose-dependent decrease of cell viability and proliferation, induced loss of plasma-membrane integrity, oxidative stress, loss of mitochondrial membrane potential (MMP), and loss of ATP content, amongst other effects. Pretreatment or co-treatment of HN with AgNPs protected cells from several of these AgNPs induced adverse effects. Thus, this study demonstrated for the first time that HN protected neuroblastoma cells against AgNPs-induced neurotoxicity. The mechanisms of the HN-mediated protective effect on neuroblastoma cells may provide further insights for the development of novel therapeutic agents against neurodegenerative diseases.

Protective effect of garlic (Allium sativum) against zinc poisoning in the testicular tissue of goldfish (Carassius auratus)

2017 ◽  
Vol 27 (2) ◽  
pp. 357-361 ◽  
Author(s):  
Seyed Mahdi Hoseinifard ◽  
Shila Omidzahir ◽  
Seyed Mohammad Hoseini ◽  
Hourie Beikaee
Keyword(s):  
Protective Effect ◽  
Carassius Auratus ◽  
Allium Sativum ◽  
Testicular Tissue ◽  
Goldfish Carassius Auratus

Protective effect of beta-carotene against titanium dioxide nanoparticles induced apoptosis in mouse testicular tissue

Andrologia ◽  
2014 ◽  
Vol 47 (7) ◽  
pp. 816-825 ◽  
Author(s):  
M. Orazizadeh ◽  
E. Daneshi ◽  
M. Hashemitmar ◽  
F. Absalan ◽  
L. Khorsandi
Keyword(s):  
Titanium Dioxide ◽  
Protective Effect ◽  
Titanium Dioxide Nanoparticles ◽  
Beta Carotene ◽  
Testicular Tissue ◽  
Induced Apoptosis

scholarly journals Synthesis and characterization of Solanum nigrum-mediated silver nanoparticles and its protective effect on alloxan-induced diabetic rats

2015 ◽  
Vol 6 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Arumugam Sengottaiyan ◽  
Adithan Aravinthan ◽  
Chinnapan Sudhakar ◽  
Kandasamy Selvam ◽  
Palanisamy Srinivasan ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Protective Effect ◽  
Diabetic Rats ◽  
Solanum Nigrum ◽  
Synthesis And Characterization

scholarly journals Therapeutic Potential of Cucumis Melo (L). Fruit Extract and Its Silver Nanopartciles Against Den Induced Hepatocellular Cancer in Rats

2021 ◽  
Author(s):  
R Vidya ◽  
K Kalaivani ◽  
P Amudha
Keyword(s):  
Silver Nanoparticles ◽  
Protective Effect ◽  
Cucumis Melo ◽  
Biological Activities ◽  
Hematological Parameters ◽  
Research Work ◽  
Histological Evaluation ◽  
Fruit Extract ◽  
Standard Drug ◽  
Wide Range

Abstract Biosynthesized silver nanoparticles have a wide range of biological activities and using nanoparticles as one of the novel approaches in cancer therapy. In this present research work, the anticancer efficacy of Cucumis melo fruit extract and its silver nanoparticles was explored. Wistar rats were divided into six groups and hepatic cancer was induced with 0.01 % DEN (diethylnitrosamine) through drinking water for 16 weeks. Cyclophosphamide was given as the standard drug at the dose of 50 mg / kg body weight. Hematological Parameters showed a decrease in the levels of hemoglobin (Hb), packed cell volume (PCV), red blood cells (RBC), mean corpuscular volume (MCV), mean corpuscular Hb (MCH), mean corpuscular Hb concentration (MCHC), and platelets (PLTS) levels except white blood cell (WBC) in DEN induced cancer animals. Significant alterations in the hematological parameters were observed after treatment which indicate the protective effect of Cucumis melo fruit on the hemopoietic system. The levels of liver function markers such as transaminases (AST ALT, ALP, LDH, GGT and 5’NT were significantly elevated in serum and liver of cancer bearing rats. Treatment with crude extract and silver nanoparticles of Cucumis melo fruit, indicating that Cucumis melo fruit could have exerted its protective effect. The levels of serum tumor markers viz., Alpha feto protein (AFP) and Carcinoembryonic antigen (CEA) elevated in rats induced with DEN, which then were reduced following Cucumis melo fruit treatment, indicating the anticancer activity of the drug. Histological evaluation of liver and kidney were also performed to authenticate the present work.

scholarly journals Allopurinol and Febuxostat Equally Attenuate Methotrexate-Induced Testicular Injury In Rats Via Activation Of EGF/ ERK1/2/HO‐1 Signaling Pathway.

2021 ◽  
Author(s):  
Remon R Rofaeil ◽  
Mohamed A. Ibrahim ◽  
Reham H. Mohyeldin ◽  
Walaa Y. Abdelzaher
Keyword(s):  
Protective Effect ◽  
Histopathological Examination ◽  
Serum Testosterone ◽  
Free Testosterone ◽  
Testicular Tissue ◽  
Testicular Damage ◽  
Purine Analogue ◽  
Tnf Α ◽  
Significant Difference ◽  
Testicular Injury

Abstract Methotrexate (MTX) is commonly used in the management of several malignancies and autoimmune disorders; however, testicular damage is one of the most detrimental effects of MTX administration. In the current study, we evaluated the possible protective effect of xanthine oxidase inhibitors either purine analogue; allopurinol (ALL) or non-purine analogue; febuxostat (FEB) in testicular injury induced by MTX in rats. Gonadotoxicity was induced by a single dose of MTX (20 mg/kg, i.p.). ALL and FEB were administered orally in the following daily doses (100, 10 mg/kg, respectively) for 15 days. Total and free testosterone were measured in serum. In addition, total antioxidant capacity (TAC), epidermal growth factor (EGF), malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), extracellular signal-regulating kinase1/2 (ERK1/2), and nitric oxide (NO) end products were measured in testicular tissues. At the same time, immunoexpression of HO-1in testicular tissue was measured. Histopathological examination was done. ALL and FEB increased total and free serum testosterone. Both drugs showed a significant reduction in testicular MDA, NO, TNF-α levels with an increase in TAC, EGF, and ERK1/2 levels in testicular tissue. Furthermore, both drugs enhanced HO-1 immunoexpression in testicular tissue. All these findings were parallel to the preservation of normal testicular architecture in rats treated with ALL and FEB. In conclusion, All and FEB were protective against testicular damage induced by MTX through anti-inflammatory, anti-apoptotic, and antioxidant actions which might be through activation of the EGF/ERK1/2/HO-1 pathway. At the same time, no significant difference between ALL and FEB was noticed in this protective effect.

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