Protective effect of beta-carotene against titanium dioxide nanoparticles induced apoptosis in mouse testicular tissue

Andrologia ◽  
2014 ◽  
Vol 47 (7) ◽  
pp. 816-825 ◽  
Author(s):  
M. Orazizadeh ◽  
E. Daneshi ◽  
M. Hashemitmar ◽  
F. Absalan ◽  
L. Khorsandi
Keyword(s):  
Titanium Dioxide ◽  
Protective Effect ◽  
Titanium Dioxide Nanoparticles ◽  
Beta Carotene ◽  
Testicular Tissue ◽  
Induced Apoptosis

scholarly journals Histological Effects of Titanium Dioxide Nanoparticles Size 10 Nm in Mice Testes

2017 ◽  
Vol 5 (2) ◽  
pp. 158 ◽  
Author(s):  
Imad Taher Abdulla
Keyword(s):  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Testicular Tissue ◽  
Germinal Epithelium ◽  
Seminiferous Tubules ◽  
Control Group ◽  
Histological Changes ◽  
Low Concentrations ◽  
High Concentrations ◽  
Histological Effect

In the present study, the histological effect of titanium dioxide nanoparticles (TDN) on testicular tissue of mature Mus musculus mice was investigated. The animals were divided into six groups, control group treated with TDN free saline and five groups treated with TDN as follow 5, 10, 50, 100 and 150 mg/kg B.W. The results showed that TDN has histological effects on testicular tissue like sever congestion, mild edema between seminiferous tubules (STs) and decrease the thickness of germinal epithelium at low concentrations, While, the histological changes at high concentrations involved disturbance in STs diameters, sever edema between STs, sever vaculation in the germinal epithelium and necrosis in spermatogonia, germinal epithelium and Sertoli cells.

Ce(IV) Doped TiO2 Nanoparticles and the Effect on Proliferation of BEL7402 Human Hepatoma Cells

2007 ◽  
Vol 330-332 ◽  
pp. 307-310
Author(s):  
L. Wang ◽  
J. Mao ◽  
X.L. Zhang ◽  
M.J. Tu ◽  
B. Kan ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Hepatoma Cells ◽  
Control Group ◽  
Impregnation Method ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Transmission Electron ◽  
Induced Apoptosis

To investigate nanoparticles’ antitumor effect, a globose 30~35nm Ce(IV) doped Titanium dioxide nanoparticles (CDT) were prepared by impregnation method and characterized by X-ray diffraction (XRD) and transmission electron microscopy(TEM). Proliferation of BEL7402 human Hepatoma cells was studied in vitro by using fluorescence microscopy and Flow Cytometry. The results show that cerium elements doping enhanced thermal stability of nano-size titanium dioxide to 800°C. With UV irradiated for 8min, BEL7402 were induced a dose-dependent apoptosis by CDT, about 28.2% , 41.5% and 88.3% cells were induced apoptosis after 24h at concentration of 60, 120 and 180ug/ml respectively, relative to 3.9% of that of control group cell just only in the presence of UV.

scholarly journals Morphometric and stereological assessment of the effects of titanium dioxide nanoparticles on the mouse testicular tissue

2017 ◽  
Vol 117 (11) ◽  
pp. 659-664
Author(s):  
L. Khorsandi ◽  
M. Orazizadeh ◽  
E. Mansouri ◽  
M. Hemadi ◽  
N. Moradi-Gharibvand
Keyword(s):  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Testicular Tissue

scholarly journals Quercetin Effects on Hepatotoxicity Induced by Titanium Dioxide Nanoparticles in Rats

2019 ◽  
Vol 15 (3) ◽  
Author(s):  
Maryam Shirani ◽  
Layasadat Khorsandi ◽  
Hadis Alidadi
Keyword(s):  
Oxidative Stress ◽  
Titanium Dioxide ◽  
Wistar Rats ◽  
Titanium Dioxide Nanoparticles ◽  
Serum Biomarker ◽  
Histological Changes ◽  
Nuclear Pyknosis ◽  
Female Wistar Rats ◽  
Body Organ ◽  
Induced Apoptosis

Background: Most nanoparticles have adverse impacts on the liver, which is a vital body organ, by the induction of oxidative stress. Objectives: This study was designed to evaluate the hepatoprotective effects of quercetin (QCT) against the toxicity of nanoscale titanium dioxide (NTiO2) in Wistar rats. Methods: The present study was conducted on 32 adult female Wistar rats assigned into 4 groups of control, NTiO2 (50 mg/kg), NTiO2 + Quercetin (50 + 75 mg/kg), and Quercetin (75 mg/kg). The animals exposed to NTiO2 were administered by 50 mg/kg of NTiO2 for 21 days. The Quercetin + NTiO2 rats received Quercetin before exposing to NTiO2 for 7 days. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) of serum were considered indicators of the hepatotoxicity. The oxidative stress was assessed by measuring the activity of catalase (CAT) and superoxide dismutase (SOD) as well as the level of malondialdehyde (MDA) in the liver. TUNEL assay and histological changes were also assessed. Results: The NTiO2 significantly elevated the MDA level (P < 0.01), enhanced the serum biomarker levels, reduced the CAT (P < 0.01) and SOD (P < 0.01) activities. The NTiO2 also aggregated the red blood cells, and caused inflammatory cell infiltration, nuclear pyknosis and fat deposit in hepatocytes, as well as induced apoptosis in the liver tissue. Pretreatment with QCT quenched oxidative stress, attenuated the histological changes, elevated the CAT (P < 0.01) and SOD (P < 0.01) activities, normalized the serum biomarker levels and decreased apoptosis (P < 0.001). Conclusions: The QCT has an inhibitory impact on hepatotoxicity induced by nanoparticles in rats.

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